Assessment of cellular response to mitogens in long-term allogeneic hematopoietic stem cell transplantation survivors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-08-22

AUTHORS

Takahiko Sato, Miyo Goto, Marie Ohbiki, Tatsunori Goto, Takanobu Morishita, Aika Seto, Yukiyasu Ozawa, Koichi Miyamura

ABSTRACT

Infection is one of the major causes of death in hematopoietic stem cell transplantation (HSCT) survivors. Precise assessments of immune function after HSCT will be critical in establishing appropriate treatment and prophylaxis, such as re-vaccination. Although several surrogate markers for prediction of clinical outcomes after HSCT have been proposed, definitive markers of immune reconstitution and data on those markers in long-term survivors are lacking. In this study, cellular response to mitogens was assessed and clinical features associated with a poor response to mitogens were investigated in long-term allogeneic HSCT survivors. Age at transplantation and age at the time of mitogen stimulation test were each identified as significant risk factors for poor response to phytohemagglutinin and concanavalin A, respectively (P < 0.001 each). However, time elapsed since transplantation was not found to be correlated with responsiveness to mitogens in this study. Prospective, in-depth studies on immune reconstitution are needed to establish appropriate prophylaxis against infections after HSCT and a schedule for re-vaccination. More... »

PAGES

682-690

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-021-03206-7

DOI

http://dx.doi.org/10.1007/s12185-021-03206-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1140580699

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34420193


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