Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-07-30

AUTHORS

Shinichi Kako, Fumihiko Hayakawa, Kiyotoshi Imai, Junji Tanaka, Shuichi Mizuta, Satoshi Nishiwaki, Heiwa Kanamori, Junichi Mukae, Yukiyasu Ozawa, Tadakazu Kondo, Takahiro Fukuda, Tatsuo Ichinohe, Shuichi Ota, Yoshinori Tanaka, Tohru Murayama, Shingo Kurahashi, Toru Sakura, Noriko Usui, Shigeki Ohtake, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Yoshiko Atsuta

ABSTRACT

The optimal treatment for Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) in first complete remission (CR1) has not been established in the high-intensity chemotherapy era. The outcomes of patients with Ph-negative ALL who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched related or unrelated donor in CR1 (HSCT-MRD group and HSCT-MUD group) were obtained from a Japanese registry database. Patients aged 16–24 years and 25–65 years were analyzed separately, and their outcomes were compared to those of patients who continued high-intensity chemotherapy in CR1 in studies (202U group and 202O group) by the Japan Adult Leukemia Study Group (JALSG). In the HSCT-MRD group, patients younger than 25 years had lower overall survival (OS) than the 202U group, presumably due to the higher non-relapse mortality (NRM) in the HSCT-MRD group. Patients 25 years and older had similar OS to the 202O group. The lower relapse rate was counterbalanced by higher NRM in the HSCT-MRD group. In the HSCT-MUD group, patients in both age groups had similar OS to their corresponding groups in the JALSG studies. In conclusion, high-intensity chemotherapy may change the role of HSCT for Ph-negative ALL. More... »

PAGES

608-619

References to SciGraph publications

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  • Journal

    TITLE

    International Journal of Hematology

    ISSUE

    5

    VOLUME

    114

    Author Affiliations

  • Division of Hematology, Department of Internal Medicine, Jichi Medical University Saitama Medical Center, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Saitama, Japan
  • Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology, Otaru General Hospital, Otaru, Japan
  • Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
  • Department of Immunology and Hematology, Kanazawa Medical University, Ishikawa, Japan
  • Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan
  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Department of Hematology, Kyoto University Hospital, Kyoto, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
  • Third Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
  • Department of Hematology, Hyogo Cancer Center, Akashi, Japan
  • Division of Hematology and Oncology, Toyohashi Municipal Hospital, Aichi, Japan
  • Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
  • Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
  • Kanazawa University, Kanazawa, Japan
  • Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology/Rheumatology, Faculty of Medicine, Kindai University, Osakasayama, Japan
  • Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
  • Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-021-03198-4

    DOI

    http://dx.doi.org/10.1007/s12185-021-03198-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1140054007

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34328634


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