Increasing numbers of CD19 + CD24highCD38high regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-07-26

AUTHORS

Tetsuya Hayashi, Hirohisa Nakamae, Shinichi Takeda, Yasuhiro Nakashima, Hideo Koh, Mitsutaka Nishimoto, Hiroshi Okamura, Satoru Nanno, Yosuke Makuuchi, Masatomo Kuno, Mika Nakamae, Asao Hirose, Masayuki Hino

ABSTRACT

The pathophysiology of immune thrombocytopenia (ITP) is poorly understood, particularly aspects regarding abnormal homeostasis and dysregulation of B cells. In this study, we analyzed peripheral lymphocyte subsets in patients with untreated ITP and healthy controls, and examined correlations between cell percentages/counts and titers of serum cytokines and antibodies. We also compared ITP patients who later required second-line therapies and those who did not. The percentages of CD19 + CD24highCD38high regulatory B cells, pre-germinal center (GC) B cells, and plasmablast-like B cells were significantly higher in ITP patients than in healthy controls. Absolute counts of regulatory B cells and pre-GC B cells were significantly higher in those who needed second-line therapies. In addition, serum B cell-activating factor belonging to the tumor necrosis factor family (BAFF) levels and platelet-associated immune globulin G antibody titers correlated positively with regulatory B cell, pre-GC B cell, and auto-reactive B cell counts. Serum interferon-α (IFN-α) levels were elevated in four ITP patients with high auto-reactive B cell counts. These results indicate that increases in regulatory B cells and pre-GC B cells may reflect activated autoimmunity induced by BAFF and/or IFN-α. Consequently, evaluation of B cell subsets in untreated ITP patients may predict treatment response. More... »

PAGES

580-590

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-021-03192-w

DOI

http://dx.doi.org/10.1007/s12185-021-03192-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1139929957

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34309815


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30 schema:description The pathophysiology of immune thrombocytopenia (ITP) is poorly understood, particularly aspects regarding abnormal homeostasis and dysregulation of B cells. In this study, we analyzed peripheral lymphocyte subsets in patients with untreated ITP and healthy controls, and examined correlations between cell percentages/counts and titers of serum cytokines and antibodies. We also compared ITP patients who later required second-line therapies and those who did not. The percentages of CD19 + CD24highCD38high regulatory B cells, pre-germinal center (GC) B cells, and plasmablast-like B cells were significantly higher in ITP patients than in healthy controls. Absolute counts of regulatory B cells and pre-GC B cells were significantly higher in those who needed second-line therapies. In addition, serum B cell-activating factor belonging to the tumor necrosis factor family (BAFF) levels and platelet-associated immune globulin G antibody titers correlated positively with regulatory B cell, pre-GC B cell, and auto-reactive B cell counts. Serum interferon-α (IFN-α) levels were elevated in four ITP patients with high auto-reactive B cell counts. These results indicate that increases in regulatory B cells and pre-GC B cells may reflect activated autoimmunity induced by BAFF and/or IFN-α. Consequently, evaluation of B cell subsets in untreated ITP patients may predict treatment response.
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38 B cells
39 B-cell counts
40 BAFF
41 CD19
42 G antibody titers
43 GC B cells
44 IFN
45 ITP patients
46 abnormal homeostasis
47 absolute counts
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53 cell count
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66 healthy controls
67 homeostasis
68 immune thrombocytopenia
69 increase
70 interferon α levels
71 levels
72 lymphocyte subsets
73 number
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77 percentage
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79 peripheral lymphocyte subsets
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81 regulatory B cells
82 response
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85 serum B cell-activating factor
86 serum cytokines
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93 tumor necrosis factor family (BAFF) levels
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