Expression of activated integrin β7 in multiple myeloma patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-05-17

AUTHORS

Naoki Hosen, Satoshi Yoshihara, Hiroyuki Takamatsu, Masaki Ri, Yasuyuki Nagata, Hiroshi Kosugi, Yoshimitsu Shimomura, Ichiro Hanamura, Shigeo Fuji, Koichiro Minauchi, Junya Kuroda, Rikio Suzuki, Noriko Nishimura, Nobuhiko Uoshima, Hirohisa Nakamae, Yawara Kawano, Ishikazu Mizuno, Hiroshi Gomyo, Kenshi Suzuki, Shuji Ozaki, Shingen Nakamura, Yoichi Imai, Masahiro Kizaki, Eiju Negoro, Hiroshi Handa, Shinsuke Iida

ABSTRACT

Multiple myeloma (MM) is still extremely difficult to cure, and new therapeutic drugs are needed. We recently found that integrin β7 is constitutively activated in MM cells, and chimeric antigen receptor (CAR) T cells targeting activated integrin β7 have a significant anti-MM effect. In this study, we performed flow cytometry analysis of the expression of activated integrin β7 in bone marrow cells from 137 symptomatic MM patients. In 60/137 (44%) MM patients, activated integrin β7 was detected in most MM cells (> 80% of MM cells were in the positive gate). Activated integrin β7 was highly expressed in MM cells even in heavily treated patients. It also showed high expression in many CD38lo/−CD138−CD19+B cells, which reportedly include clonotypic B cells, in the bone marrow of MM patients. Taken together, these results suggest that CAR T-cell therapy targeting activated integrin β7 has the potential to benefit many patients with relapsed or refractory MM. More... »

PAGES

3-7

Journal

TITLE

International Journal of Hematology

ISSUE

1

VOLUME

114

Author Affiliations

  • Department of Cellular Immunotherapy, Osaka University Immunology Frontier Research Center, Suita, Japan
  • Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
  • Department of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
  • Department of Hematology and Oncology, Institute of Medical and Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
  • Division of Hematology, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan
  • Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
  • Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan
  • Department of Hematology, Osaka International Cancer Institute, Osaka, Japan
  • Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
  • Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Department of Hematology/Oncology, Tokai University School of Medicine, Tokyo, Japan
  • Department of Hematology Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
  • Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan
  • Department of Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan
  • Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Department of Hematology, Hyogo Cancer Center, Akashi, Japan
  • Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
  • Department of Hematology, Tokushima Prefectural Central Hospital, Tokushima, Japan
  • Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
  • Department of Hematology/Oncology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Department of Hematology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
  • Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
  • Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-021-03162-2

    DOI

    http://dx.doi.org/10.1007/s12185-021-03162-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1138109657

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33999338


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