Biopsy remains indispensable for evaluating bone marrow involvement in DLBCL patients despite the use of positron emission tomography View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-01-30

AUTHORS

Yusuke Saiki, Naoto Tomita, Akiko Uchida, Yu Uemura, Yoshinori Suzuki, Tsuneaki Hirakawa, Masayuki Kato, Masahiro Hoshikawa, Tsuyoshi Kawano, Naoya Nakamura, Ikuo Miura, Ayako Arai

ABSTRACT

Initial staging by positron emission tomography/computed tomography (PET/CT) scanning is recommended for patients with diffuse large B-cell lymphoma (DLBCL). Whether both PET/CT and bone marrow biopsy (BMB) are required remains unclear. This study examined whether staging by PET/CT is sufficient. Participants with untreated DLBCL assessed using both PET/CT and BMB were included. Patients received independent diagnostic assessments from a radiologist and a hematopathologist. Both hematoxylin–eosin staining and CD20 immunostaining were performed to determine the bone marrow involvement in BMB. A total of 84 patients were included. The number of patients with positive bone marrow involvement identified by PET/CT and BMB was 16 (19%) and 22 (26%), respectively. Eight (10%) patients showed positive results in both tests. When considering BMB as a reference, PET/CT showed 36% sensitivity and 87% specificity, with positive and negative predictive values of 50% and 79%, respectively. BMB-positive patients had shorter progression-free (PFS) and overall (OS) survival than their BMB-negative counterparts. Compared to PET/CT-negative patients, patients with positive results did not show any significant differences in PFS and OS. However, among 16 PET/CT-positive patients, poor PFS and OS were observed among patients who were also BMB positive. BMB remains a mandatory step in staging of untreated DLBCL patients. More... »

PAGES

675-681

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-021-03080-3

DOI

http://dx.doi.org/10.1007/s12185-021-03080-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1134988469

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33515158


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Large B-Cell, Diffuse", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron Emission Tomography Computed Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saiki", 
        "givenName": "Yusuke", 
        "id": "sg:person.015051707066.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015051707066.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomita", 
        "givenName": "Naoto", 
        "id": "sg:person.01155656464.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155656464.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchida", 
        "givenName": "Akiko", 
        "id": "sg:person.01270754525.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270754525.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uemura", 
        "givenName": "Yu", 
        "id": "sg:person.01173656345.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173656345.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Yoshinori", 
        "id": "sg:person.0745036624.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745036624.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirakawa", 
        "givenName": "Tsuneaki", 
        "id": "sg:person.01072712142.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072712142.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Masayuki", 
        "id": "sg:person.01061265224.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061265224.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoshikawa", 
        "givenName": "Masahiro", 
        "id": "sg:person.01144352414.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144352414.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, YUAI Clinic, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Radiology, YUAI Clinic, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawano", 
        "givenName": "Tsuyoshi", 
        "id": "sg:person.010472456737.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010472456737.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Naoya", 
        "id": "sg:person.01055064002.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055064002.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miura", 
        "givenName": "Ikuo", 
        "id": "sg:person.01053556252.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053556252.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412764.2", 
          "name": [
            "Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arai", 
        "givenName": "Ayako", 
        "id": "sg:person.0670234447.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670234447.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00277-011-1353-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026885290", 
          "https://doi.org/10.1007/s00277-011-1353-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-013-2623-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022073725", 
          "https://doi.org/10.1007/s00259-013-2623-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12094-015-1393-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045575940", 
          "https://doi.org/10.1007/s12094-015-1393-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-8722-6-76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036491582", 
          "https://doi.org/10.1186/1756-8722-6-76"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-01-30", 
    "datePublishedReg": "2021-01-30", 
    "description": "Initial staging by positron emission tomography/computed tomography (PET/CT) scanning is recommended for patients with diffuse large B-cell lymphoma (DLBCL). Whether both PET/CT and bone marrow biopsy (BMB) are required remains unclear. This study examined whether staging by PET/CT is sufficient. Participants with untreated DLBCL assessed using both PET/CT and BMB were included. Patients received independent diagnostic assessments from a radiologist and a hematopathologist. Both hematoxylin\u2013eosin staining and CD20 immunostaining were performed to determine the bone marrow involvement in BMB. A total of 84 patients were included. The number of patients with positive bone marrow involvement identified by PET/CT and BMB was 16 (19%) and 22 (26%), respectively. Eight (10%) patients showed positive results in both tests. When considering BMB as a reference, PET/CT showed 36% sensitivity and 87% specificity, with positive and negative predictive values of 50% and 79%, respectively. BMB-positive patients had shorter progression-free (PFS) and overall (OS) survival than their BMB-negative counterparts. Compared to PET/CT-negative patients, patients with positive results did not show any significant differences in PFS and OS. However, among 16 PET/CT-positive patients, poor PFS and OS were observed among patients who were also BMB positive. BMB remains a mandatory step in staging of untreated DLBCL patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12185-021-03080-3", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.9199708", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1076985", 
        "issn": [
          "0925-5710", 
          "1865-3774"
        ], 
        "name": "International Journal of Hematology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "113"
      }
    ], 
    "keywords": [
      "bone marrow biopsy", 
      "diffuse large B-cell lymphoma", 
      "PET/CT", 
      "bone marrow involvement", 
      "marrow involvement", 
      "DLBCL patients", 
      "untreated diffuse large B-cell lymphoma", 
      "PET/CT-negative patients", 
      "PET/CT-positive patients", 
      "positron emission tomography/", 
      "large B-cell lymphoma", 
      "CT-negative patients", 
      "CT-positive patients", 
      "emission tomography/", 
      "number of patients", 
      "untreated DLBCL patients", 
      "hematoxylin-eosin staining", 
      "B-cell lymphoma", 
      "negative predictive value", 
      "independent diagnostic assessment", 
      "positron emission tomography", 
      "BMB-positive patients", 
      "positive results", 
      "initial staging", 
      "overall survival", 
      "poor PFS", 
      "marrow biopsy", 
      "tomography/", 
      "patients", 
      "predictive value", 
      "tomography scanning", 
      "emission tomography", 
      "diagnostic assessment", 
      "CT", 
      "significant differences", 
      "biopsy", 
      "PFS", 
      "staging", 
      "involvement", 
      "OS", 
      "CD20", 
      "lymphoma", 
      "hematopathologists", 
      "survival", 
      "staining", 
      "tomography", 
      "radiologists", 
      "total", 
      "participants", 
      "specificity", 
      "assessment", 
      "mandatory step", 
      "differences", 
      "study", 
      "sensitivity", 
      "test", 
      "scanning", 
      "results", 
      "use", 
      "number", 
      "counterparts", 
      "values", 
      "reference", 
      "step"
    ], 
    "name": "Biopsy remains indispensable for evaluating bone marrow involvement in DLBCL patients despite the use of positron emission tomography", 
    "pagination": "675-681", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1134988469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12185-021-03080-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33515158"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12185-021-03080-3", 
      "https://app.dimensions.ai/details/publication/pub.1134988469"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_900.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12185-021-03080-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-021-03080-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-021-03080-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-021-03080-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-021-03080-3'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      22 PREDICATES      108 URIs      96 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12185-021-03080-3 schema:about N0347f8337f484befb3100545ac788155
2 N13e9413e726542868a5cfab56e0d5514
3 N4903d0cc1c674793a1bd1eae90631d59
4 N4c760abdddfa4e8bbc2a7eaea53115a0
5 N50decf33ee0e4e79b9a7734333c206eb
6 N5d872e4bbd474971b0b82c4d37941842
7 N81330533fe754339ae749fb63cca43a4
8 N8562b449ce384a7ba943c08db3601d5f
9 N92a8b817fe7849f8beff4cbb5b61badd
10 Na6bc38a2fcca4e2ea3b0b0147d3df3b6
11 Nafdd3a0560ff4ce4bc50459bd7500200
12 Nd34988a3acb8440690886bce51d049ad
13 Nd6139591a6e14b5eab4c9e6939856238
14 Nfb289c41f3ac4a44b79e918564aa723f
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nd0a7d498da024d3e9a4a76aa6d7c3706
18 schema:citation sg:pub.10.1007/s00259-013-2623-4
19 sg:pub.10.1007/s00277-011-1353-6
20 sg:pub.10.1007/s12094-015-1393-9
21 sg:pub.10.1186/1756-8722-6-76
22 schema:datePublished 2021-01-30
23 schema:datePublishedReg 2021-01-30
24 schema:description Initial staging by positron emission tomography/computed tomography (PET/CT) scanning is recommended for patients with diffuse large B-cell lymphoma (DLBCL). Whether both PET/CT and bone marrow biopsy (BMB) are required remains unclear. This study examined whether staging by PET/CT is sufficient. Participants with untreated DLBCL assessed using both PET/CT and BMB were included. Patients received independent diagnostic assessments from a radiologist and a hematopathologist. Both hematoxylin–eosin staining and CD20 immunostaining were performed to determine the bone marrow involvement in BMB. A total of 84 patients were included. The number of patients with positive bone marrow involvement identified by PET/CT and BMB was 16 (19%) and 22 (26%), respectively. Eight (10%) patients showed positive results in both tests. When considering BMB as a reference, PET/CT showed 36% sensitivity and 87% specificity, with positive and negative predictive values of 50% and 79%, respectively. BMB-positive patients had shorter progression-free (PFS) and overall (OS) survival than their BMB-negative counterparts. Compared to PET/CT-negative patients, patients with positive results did not show any significant differences in PFS and OS. However, among 16 PET/CT-positive patients, poor PFS and OS were observed among patients who were also BMB positive. BMB remains a mandatory step in staging of untreated DLBCL patients.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N3d3bb8e0f8b84ed3acebb51e7ca15388
29 Nc33449ce2098454091c65e57ffd798c8
30 sg:journal.1076985
31 schema:keywords B-cell lymphoma
32 BMB-positive patients
33 CD20
34 CT
35 CT-negative patients
36 CT-positive patients
37 DLBCL patients
38 OS
39 PET/CT
40 PET/CT-negative patients
41 PET/CT-positive patients
42 PFS
43 assessment
44 biopsy
45 bone marrow biopsy
46 bone marrow involvement
47 counterparts
48 diagnostic assessment
49 differences
50 diffuse large B-cell lymphoma
51 emission tomography
52 emission tomography/
53 hematopathologists
54 hematoxylin-eosin staining
55 independent diagnostic assessment
56 initial staging
57 involvement
58 large B-cell lymphoma
59 lymphoma
60 mandatory step
61 marrow biopsy
62 marrow involvement
63 negative predictive value
64 number
65 number of patients
66 overall survival
67 participants
68 patients
69 poor PFS
70 positive results
71 positron emission tomography
72 positron emission tomography/
73 predictive value
74 radiologists
75 reference
76 results
77 scanning
78 sensitivity
79 significant differences
80 specificity
81 staging
82 staining
83 step
84 study
85 survival
86 test
87 tomography
88 tomography scanning
89 tomography/
90 total
91 untreated DLBCL patients
92 untreated diffuse large B-cell lymphoma
93 use
94 values
95 schema:name Biopsy remains indispensable for evaluating bone marrow involvement in DLBCL patients despite the use of positron emission tomography
96 schema:pagination 675-681
97 schema:productId N8148bd0b835c4414a979450192f14477
98 Na79fb05222044ad787774beefa095ce3
99 Ndecbb152acc34db9b7dc173153e6d911
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1134988469
101 https://doi.org/10.1007/s12185-021-03080-3
102 schema:sdDatePublished 2022-05-20T07:39
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N7e23a3d929b64ec2a29ad7014e84b765
105 schema:url https://doi.org/10.1007/s12185-021-03080-3
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N0347f8337f484befb3100545ac788155 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Lymphoma, Large B-Cell, Diffuse
111 rdf:type schema:DefinedTerm
112 N13e9413e726542868a5cfab56e0d5514 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Male
114 rdf:type schema:DefinedTerm
115 N292409d92cb043f484838223b38b728a rdf:first sg:person.01155656464.01
116 rdf:rest Nba556d1fe4804a7e9e5f510e49d323dc
117 N3d3bb8e0f8b84ed3acebb51e7ca15388 schema:volumeNumber 113
118 rdf:type schema:PublicationVolume
119 N4903d0cc1c674793a1bd1eae90631d59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Neoplasm Staging
121 rdf:type schema:DefinedTerm
122 N4ba7cb2eebf946f1a5a3f0f0ec91db2d rdf:first sg:person.01055064002.85
123 rdf:rest Ne97afd486d1541aa85238e2cdfd3b7bd
124 N4c760abdddfa4e8bbc2a7eaea53115a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Aged
126 rdf:type schema:DefinedTerm
127 N4e50b01aa3574816a78afd48a521b755 rdf:first sg:person.0745036624.93
128 rdf:rest Nd4ca1744dbaf4b25a7a58955d95e2935
129 N50decf33ee0e4e79b9a7734333c206eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Aged, 80 and over
131 rdf:type schema:DefinedTerm
132 N516d1ca7ac9b4249a745e3ca8d8bf40c rdf:first sg:person.01144352414.40
133 rdf:rest Nd6628744afc24248b16aa5ea6e6c2389
134 N5d872e4bbd474971b0b82c4d37941842 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Positron Emission Tomography Computed Tomography
136 rdf:type schema:DefinedTerm
137 N7e23a3d929b64ec2a29ad7014e84b765 schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N81330533fe754339ae749fb63cca43a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Prognosis
141 rdf:type schema:DefinedTerm
142 N8148bd0b835c4414a979450192f14477 schema:name pubmed_id
143 schema:value 33515158
144 rdf:type schema:PropertyValue
145 N8562b449ce384a7ba943c08db3601d5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Bone Marrow
147 rdf:type schema:DefinedTerm
148 N8e68e2b4ce764b4081d73b70d07f4e26 rdf:first sg:person.01061265224.67
149 rdf:rest N516d1ca7ac9b4249a745e3ca8d8bf40c
150 N92a8b817fe7849f8beff4cbb5b61badd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Biopsy
152 rdf:type schema:DefinedTerm
153 Na6bc38a2fcca4e2ea3b0b0147d3df3b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Humans
155 rdf:type schema:DefinedTerm
156 Na79fb05222044ad787774beefa095ce3 schema:name dimensions_id
157 schema:value pub.1134988469
158 rdf:type schema:PropertyValue
159 Nafdd3a0560ff4ce4bc50459bd7500200 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Adult
161 rdf:type schema:DefinedTerm
162 Nba556d1fe4804a7e9e5f510e49d323dc rdf:first sg:person.01270754525.23
163 rdf:rest Ncedcdeb3965d43108d6f2ad1170c2aa4
164 Nc33449ce2098454091c65e57ffd798c8 schema:issueNumber 5
165 rdf:type schema:PublicationIssue
166 Ncde6ee96297a411fb0242067393bdf6d rdf:first sg:person.0670234447.83
167 rdf:rest rdf:nil
168 Ncedcdeb3965d43108d6f2ad1170c2aa4 rdf:first sg:person.01173656345.09
169 rdf:rest N4e50b01aa3574816a78afd48a521b755
170 Nd0a7d498da024d3e9a4a76aa6d7c3706 rdf:first sg:person.015051707066.73
171 rdf:rest N292409d92cb043f484838223b38b728a
172 Nd34988a3acb8440690886bce51d049ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Young Adult
174 rdf:type schema:DefinedTerm
175 Nd4ca1744dbaf4b25a7a58955d95e2935 rdf:first sg:person.01072712142.88
176 rdf:rest N8e68e2b4ce764b4081d73b70d07f4e26
177 Nd6139591a6e14b5eab4c9e6939856238 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Middle Aged
179 rdf:type schema:DefinedTerm
180 Nd6628744afc24248b16aa5ea6e6c2389 rdf:first sg:person.010472456737.04
181 rdf:rest N4ba7cb2eebf946f1a5a3f0f0ec91db2d
182 Ndecbb152acc34db9b7dc173153e6d911 schema:name doi
183 schema:value 10.1007/s12185-021-03080-3
184 rdf:type schema:PropertyValue
185 Ne97afd486d1541aa85238e2cdfd3b7bd rdf:first sg:person.01053556252.90
186 rdf:rest Ncde6ee96297a411fb0242067393bdf6d
187 Nfb289c41f3ac4a44b79e918564aa723f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Female
189 rdf:type schema:DefinedTerm
190 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
191 schema:name Medical and Health Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
194 schema:name Clinical Sciences
195 rdf:type schema:DefinedTerm
196 sg:grant.9199708 http://pending.schema.org/fundedItem sg:pub.10.1007/s12185-021-03080-3
197 rdf:type schema:MonetaryGrant
198 sg:journal.1076985 schema:issn 0925-5710
199 1865-3774
200 schema:name International Journal of Hematology
201 schema:publisher Springer Nature
202 rdf:type schema:Periodical
203 sg:person.010472456737.04 schema:affiliation grid-institutes:None
204 schema:familyName Kawano
205 schema:givenName Tsuyoshi
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010472456737.04
207 rdf:type schema:Person
208 sg:person.01053556252.90 schema:affiliation grid-institutes:grid.412764.2
209 schema:familyName Miura
210 schema:givenName Ikuo
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053556252.90
212 rdf:type schema:Person
213 sg:person.01055064002.85 schema:affiliation grid-institutes:grid.265061.6
214 schema:familyName Nakamura
215 schema:givenName Naoya
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055064002.85
217 rdf:type schema:Person
218 sg:person.01061265224.67 schema:affiliation grid-institutes:grid.412764.2
219 schema:familyName Kato
220 schema:givenName Masayuki
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061265224.67
222 rdf:type schema:Person
223 sg:person.01072712142.88 schema:affiliation grid-institutes:grid.412764.2
224 schema:familyName Hirakawa
225 schema:givenName Tsuneaki
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072712142.88
227 rdf:type schema:Person
228 sg:person.01144352414.40 schema:affiliation grid-institutes:grid.412764.2
229 schema:familyName Hoshikawa
230 schema:givenName Masahiro
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144352414.40
232 rdf:type schema:Person
233 sg:person.01155656464.01 schema:affiliation grid-institutes:grid.412764.2
234 schema:familyName Tomita
235 schema:givenName Naoto
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155656464.01
237 rdf:type schema:Person
238 sg:person.01173656345.09 schema:affiliation grid-institutes:grid.412764.2
239 schema:familyName Uemura
240 schema:givenName Yu
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173656345.09
242 rdf:type schema:Person
243 sg:person.01270754525.23 schema:affiliation grid-institutes:grid.412764.2
244 schema:familyName Uchida
245 schema:givenName Akiko
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270754525.23
247 rdf:type schema:Person
248 sg:person.015051707066.73 schema:affiliation grid-institutes:grid.412764.2
249 schema:familyName Saiki
250 schema:givenName Yusuke
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015051707066.73
252 rdf:type schema:Person
253 sg:person.0670234447.83 schema:affiliation grid-institutes:grid.412764.2
254 schema:familyName Arai
255 schema:givenName Ayako
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670234447.83
257 rdf:type schema:Person
258 sg:person.0745036624.93 schema:affiliation grid-institutes:grid.412764.2
259 schema:familyName Suzuki
260 schema:givenName Yoshinori
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745036624.93
262 rdf:type schema:Person
263 sg:pub.10.1007/s00259-013-2623-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022073725
264 https://doi.org/10.1007/s00259-013-2623-4
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s00277-011-1353-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026885290
267 https://doi.org/10.1007/s00277-011-1353-6
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s12094-015-1393-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045575940
270 https://doi.org/10.1007/s12094-015-1393-9
271 rdf:type schema:CreativeWork
272 sg:pub.10.1186/1756-8722-6-76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036491582
273 https://doi.org/10.1186/1756-8722-6-76
274 rdf:type schema:CreativeWork
275 grid-institutes:None schema:alternateName Department of Radiology, YUAI Clinic, Yokohama, Japan
276 schema:name Department of Radiology, YUAI Clinic, Yokohama, Japan
277 rdf:type schema:Organization
278 grid-institutes:grid.265061.6 schema:alternateName Department of Pathology, Tokai University School of Medicine, Isehara, Japan
279 schema:name Department of Pathology, Tokai University School of Medicine, Isehara, Japan
280 rdf:type schema:Organization
281 grid-institutes:grid.412764.2 schema:alternateName Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan
282 Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan
283 schema:name Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan
284 Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...