Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-09-26

AUTHORS

Fumiya Wada, Momoko Nishikori, Masakatsu Hishizawa, Mitsumasa Watanabe, Akiko Aiba, Toshiyuki Kitano, Yayoi Shimazu, Takero Shindo, Tadakazu Kondo, Akifumi Takaori-Kondo

ABSTRACT

Autologous stem cell transplantation (ASCT) with high-dose thiotepa and busulfan is a treatment option for patients with central nervous system (CNS) lymphoma. We report here the occurrence of secondary failure of platelet recovery (SFPR) in three out of 24 patients who received high-dose thiotepa and busulfan followed by ASCT. Although there was no obvious abnormality in the primary platelet engraftment as well as the recovery of other blood cells, they developed SFPR with a median time to onset of day 38, and the platelets gradually recovered over several months with steroid therapy. During the same period, there was no development of SFPR among 50 patients who received ASCT with a conditioning regimen of MEAM (ranimustine, etoposide, cytarabine, and melphalan) or high-dose melphalan. However, one of the two patients who received a conditioning regimen of busulfan and melphalan developed SFPR, suggesting that the use of a busulfan-based conditioning regimen may be one of the risk factors for SFPR. It is important to be aware of this possible adverse effect of ASCT with high-dose thiotepa and busulfan to ensure timely diagnosis and prevention of subsequent serious complications. More... »

PAGES

609-613

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-020-03007-4

DOI

http://dx.doi.org/10.1007/s12185-020-03007-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131201517

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32980953


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Busulfan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Central Nervous System Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiotepa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombocytopenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Autologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wada", 
        "givenName": "Fumiya", 
        "id": "sg:person.013732164761.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732164761.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishikori", 
        "givenName": "Momoko", 
        "id": "sg:person.01302524155.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302524155.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hishizawa", 
        "givenName": "Masakatsu", 
        "id": "sg:person.01133351543.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133351543.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413697.e", 
          "name": [
            "Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Mitsumasa", 
        "id": "sg:person.01227027220.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227027220.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415392.8", 
          "name": [
            "Department of Hematology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aiba", 
        "givenName": "Akiko", 
        "id": "sg:person.07506646357.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07506646357.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415392.8", 
          "name": [
            "Department of Hematology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitano", 
        "givenName": "Toshiyuki", 
        "id": "sg:person.01131141544.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131141544.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414936.d", 
          "name": [
            "Department of Hematology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimazu", 
        "givenName": "Yayoi", 
        "id": "sg:person.0721117322.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721117322.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shindo", 
        "givenName": "Takero", 
        "id": "sg:person.01242172154.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242172154.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondo", 
        "givenName": "Tadakazu", 
        "id": "sg:person.0666225507.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takaori-Kondo", 
        "givenName": "Akifumi", 
        "id": "sg:person.0743352217.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743352217.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bmt.1704073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029779862", 
          "https://doi.org/10.1038/sj.bmt.1704073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1702658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010107542", 
          "https://doi.org/10.1038/sj.bmt.1702658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11912-019-0838-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1120335693", 
          "https://doi.org/10.1007/s11912-019-0838-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025202013", 
          "https://doi.org/10.1038/sj.bmt.1705820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-019-03914-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1120402965", 
          "https://doi.org/10.1007/s00280-019-03914-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-009-0261-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027253340", 
          "https://doi.org/10.1007/s12185-009-0261-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043147565", 
          "https://doi.org/10.1038/sj.bmt.1705758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1704574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042606831", 
          "https://doi.org/10.1038/sj.bmt.1704574"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-09-26", 
    "datePublishedReg": "2020-09-26", 
    "description": "Autologous stem cell transplantation (ASCT) with high-dose thiotepa and busulfan is a treatment option for patients with central nervous system (CNS) lymphoma. We report here the occurrence of secondary failure of platelet recovery (SFPR) in three out of 24 patients who received high-dose thiotepa and busulfan followed by ASCT. Although there was no obvious abnormality in the primary platelet engraftment as well as the recovery of other blood cells, they developed SFPR with a median time to onset of day 38, and the platelets gradually recovered over several months with steroid therapy. During the same period, there was no development of SFPR among 50 patients who received ASCT with a conditioning regimen of MEAM (ranimustine, etoposide, cytarabine, and melphalan) or high-dose melphalan. However, one of the two patients who received a conditioning regimen of busulfan and melphalan developed SFPR, suggesting that the use of a busulfan-based conditioning regimen may be one of the risk factors for SFPR. It is important to be aware of this possible adverse effect of ASCT with high-dose thiotepa and busulfan to ensure timely diagnosis and prevention of subsequent serious complications.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12185-020-03007-4", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7535154", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1076985", 
        "issn": [
          "0925-5710", 
          "1865-3774"
        ], 
        "name": "International Journal of Hematology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "112"
      }
    ], 
    "keywords": [
      "autologous stem cell transplantation", 
      "high-dose thiotepa", 
      "stem cell transplantation", 
      "conditioning regimen", 
      "cell transplantation", 
      "platelet recovery", 
      "secondary failure", 
      "busulfan-based conditioning regimen", 
      "central nervous system lymphoma", 
      "subsequent serious complications", 
      "high-dose melphalan", 
      "nervous system lymphoma", 
      "possible adverse effects", 
      "steroid therapy", 
      "platelet engraftment", 
      "system lymphoma", 
      "serious complications", 
      "median time", 
      "treatment options", 
      "risk factors", 
      "timely diagnosis", 
      "busulfan", 
      "patients", 
      "thiotepa", 
      "day 38", 
      "regimen", 
      "obvious abnormalities", 
      "blood cells", 
      "adverse effects", 
      "transplantation", 
      "melphalan", 
      "same period", 
      "SFPR", 
      "complications", 
      "failure", 
      "lymphoma", 
      "engraftment", 
      "therapy", 
      "abnormalities", 
      "diagnosis", 
      "recovery", 
      "months", 
      "prevention", 
      "platelets", 
      "onset", 
      "cells", 
      "options", 
      "period", 
      "factors", 
      "occurrence", 
      "effect", 
      "use", 
      "development", 
      "time", 
      "MEAM"
    ], 
    "name": "Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation", 
    "pagination": "609-613", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1131201517"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12185-020-03007-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32980953"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12185-020-03007-4", 
      "https://app.dimensions.ai/details/publication/pub.1131201517"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_836.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12185-020-03007-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-020-03007-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-020-03007-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-020-03007-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-020-03007-4'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      103 URIs      87 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12185-020-03007-4 schema:about N127c0b94dd41429b9867ba3d8e649338
2 N2204d6a7b22d4df5a9c21e8a086119ce
3 N3004c99b90a74b31b48cff25e0cc9472
4 N314dc04113314d4293deca75a195aa7f
5 N39c5b75ed50e4d9fb25d2503897560ad
6 N4c7ff808fa114f0a86c1b4933e5a4055
7 N53011ad3f3a047a1b9028ad364d2025f
8 N759f6120b3424bf19f671b4436a316b4
9 N81106b4dc1e0414ea006828dbfc0f616
10 Naab29e08662b40e29fd7d21343211f5a
11 Nafbdf9102a8042b29754beb10692d906
12 Nba5b78d2df3f4470b78ab085e7ab2dbc
13 Nd2a4957371d54125801f7cf08ae693e0
14 Ne3159dfaaf2341878f4f24affa677a37
15 Nf070ada4595f4542919075f36de248da
16 anzsrc-for:11
17 anzsrc-for:1102
18 schema:author Nd6730ee66e0449a0bcba0fc761262bb4
19 schema:citation sg:pub.10.1007/s00280-019-03914-2
20 sg:pub.10.1007/s11912-019-0838-7
21 sg:pub.10.1007/s12185-009-0261-1
22 sg:pub.10.1038/sj.bmt.1702658
23 sg:pub.10.1038/sj.bmt.1704073
24 sg:pub.10.1038/sj.bmt.1704574
25 sg:pub.10.1038/sj.bmt.1705758
26 sg:pub.10.1038/sj.bmt.1705820
27 schema:datePublished 2020-09-26
28 schema:datePublishedReg 2020-09-26
29 schema:description Autologous stem cell transplantation (ASCT) with high-dose thiotepa and busulfan is a treatment option for patients with central nervous system (CNS) lymphoma. We report here the occurrence of secondary failure of platelet recovery (SFPR) in three out of 24 patients who received high-dose thiotepa and busulfan followed by ASCT. Although there was no obvious abnormality in the primary platelet engraftment as well as the recovery of other blood cells, they developed SFPR with a median time to onset of day 38, and the platelets gradually recovered over several months with steroid therapy. During the same period, there was no development of SFPR among 50 patients who received ASCT with a conditioning regimen of MEAM (ranimustine, etoposide, cytarabine, and melphalan) or high-dose melphalan. However, one of the two patients who received a conditioning regimen of busulfan and melphalan developed SFPR, suggesting that the use of a busulfan-based conditioning regimen may be one of the risk factors for SFPR. It is important to be aware of this possible adverse effect of ASCT with high-dose thiotepa and busulfan to ensure timely diagnosis and prevention of subsequent serious complications.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf N0b098efca5d847a795533842cb732294
33 Nd5e4d7587f884ece92b926c5637fe6c3
34 sg:journal.1076985
35 schema:keywords MEAM
36 SFPR
37 abnormalities
38 adverse effects
39 autologous stem cell transplantation
40 blood cells
41 busulfan
42 busulfan-based conditioning regimen
43 cell transplantation
44 cells
45 central nervous system lymphoma
46 complications
47 conditioning regimen
48 day 38
49 development
50 diagnosis
51 effect
52 engraftment
53 factors
54 failure
55 high-dose melphalan
56 high-dose thiotepa
57 lymphoma
58 median time
59 melphalan
60 months
61 nervous system lymphoma
62 obvious abnormalities
63 occurrence
64 onset
65 options
66 patients
67 period
68 platelet engraftment
69 platelet recovery
70 platelets
71 possible adverse effects
72 prevention
73 recovery
74 regimen
75 risk factors
76 same period
77 secondary failure
78 serious complications
79 stem cell transplantation
80 steroid therapy
81 subsequent serious complications
82 system lymphoma
83 therapy
84 thiotepa
85 time
86 timely diagnosis
87 transplantation
88 treatment options
89 use
90 schema:name Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation
91 schema:pagination 609-613
92 schema:productId N183d7beb785f46f2acb2eb8f1fdf42f1
93 N20631cd41bfa490a8504b2f832f10845
94 N5d29d6ba7d104749bd46c26da64d08c1
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131201517
96 https://doi.org/10.1007/s12185-020-03007-4
97 schema:sdDatePublished 2022-11-24T21:04
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher Nd20b75a662194770af8c9ef0f123cd23
100 schema:url https://doi.org/10.1007/s12185-020-03007-4
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N04d7d72bad3f4ff8934549a1507aa84e rdf:first sg:person.07506646357.42
105 rdf:rest Nd7ca49e5e4304a4b904d4f8d35ec6fde
106 N0b098efca5d847a795533842cb732294 schema:issueNumber 5
107 rdf:type schema:PublicationIssue
108 N127c0b94dd41429b9867ba3d8e649338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adult
110 rdf:type schema:DefinedTerm
111 N183d7beb785f46f2acb2eb8f1fdf42f1 schema:name doi
112 schema:value 10.1007/s12185-020-03007-4
113 rdf:type schema:PropertyValue
114 N1d21f75c4d364d208efb1f603a34fd6d rdf:first sg:person.01242172154.57
115 rdf:rest N39a2d68e177645b2bce6ef58f7893298
116 N20631cd41bfa490a8504b2f832f10845 schema:name dimensions_id
117 schema:value pub.1131201517
118 rdf:type schema:PropertyValue
119 N2204d6a7b22d4df5a9c21e8a086119ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Time Factors
121 rdf:type schema:DefinedTerm
122 N29704d5ebdb8485a88cec806a747f6e9 rdf:first sg:person.01302524155.21
123 rdf:rest N2d03425b03404553a1a3f74b8bcff83b
124 N2d03425b03404553a1a3f74b8bcff83b rdf:first sg:person.01133351543.21
125 rdf:rest Ndcde03c63469423e83cb4add4bcb5c18
126 N3004c99b90a74b31b48cff25e0cc9472 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Transplantation Conditioning
128 rdf:type schema:DefinedTerm
129 N314dc04113314d4293deca75a195aa7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Middle Aged
131 rdf:type schema:DefinedTerm
132 N39a2d68e177645b2bce6ef58f7893298 rdf:first sg:person.0666225507.36
133 rdf:rest Nc39ed0ce6377456e898b0f1d29093440
134 N39c5b75ed50e4d9fb25d2503897560ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Aged
136 rdf:type schema:DefinedTerm
137 N4c7ff808fa114f0a86c1b4933e5a4055 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Hematopoietic Stem Cell Transplantation
139 rdf:type schema:DefinedTerm
140 N53011ad3f3a047a1b9028ad364d2025f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Male
142 rdf:type schema:DefinedTerm
143 N5d29d6ba7d104749bd46c26da64d08c1 schema:name pubmed_id
144 schema:value 32980953
145 rdf:type schema:PropertyValue
146 N759f6120b3424bf19f671b4436a316b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Central Nervous System Neoplasms
148 rdf:type schema:DefinedTerm
149 N81106b4dc1e0414ea006828dbfc0f616 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Thrombocytopenia
151 rdf:type schema:DefinedTerm
152 N8e4dbd4700b047999d9e1a615e0bc72c rdf:first sg:person.0721117322.46
153 rdf:rest N1d21f75c4d364d208efb1f603a34fd6d
154 Naab29e08662b40e29fd7d21343211f5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Thiotepa
156 rdf:type schema:DefinedTerm
157 Nafbdf9102a8042b29754beb10692d906 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Lymphoma
159 rdf:type schema:DefinedTerm
160 Nba5b78d2df3f4470b78ab085e7ab2dbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Busulfan
162 rdf:type schema:DefinedTerm
163 Nc39ed0ce6377456e898b0f1d29093440 rdf:first sg:person.0743352217.37
164 rdf:rest rdf:nil
165 Nd20b75a662194770af8c9ef0f123cd23 schema:name Springer Nature - SN SciGraph project
166 rdf:type schema:Organization
167 Nd2a4957371d54125801f7cf08ae693e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Transplantation, Autologous
169 rdf:type schema:DefinedTerm
170 Nd5e4d7587f884ece92b926c5637fe6c3 schema:volumeNumber 112
171 rdf:type schema:PublicationVolume
172 Nd6730ee66e0449a0bcba0fc761262bb4 rdf:first sg:person.013732164761.79
173 rdf:rest N29704d5ebdb8485a88cec806a747f6e9
174 Nd7ca49e5e4304a4b904d4f8d35ec6fde rdf:first sg:person.01131141544.47
175 rdf:rest N8e4dbd4700b047999d9e1a615e0bc72c
176 Ndcde03c63469423e83cb4add4bcb5c18 rdf:first sg:person.01227027220.06
177 rdf:rest N04d7d72bad3f4ff8934549a1507aa84e
178 Ne3159dfaaf2341878f4f24affa677a37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 Nf070ada4595f4542919075f36de248da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Female
183 rdf:type schema:DefinedTerm
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
188 schema:name Cardiorespiratory Medicine and Haematology
189 rdf:type schema:DefinedTerm
190 sg:grant.7535154 http://pending.schema.org/fundedItem sg:pub.10.1007/s12185-020-03007-4
191 rdf:type schema:MonetaryGrant
192 sg:journal.1076985 schema:issn 0925-5710
193 1865-3774
194 schema:name International Journal of Hematology
195 schema:publisher Springer Nature
196 rdf:type schema:Periodical
197 sg:person.01131141544.47 schema:affiliation grid-institutes:grid.415392.8
198 schema:familyName Kitano
199 schema:givenName Toshiyuki
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131141544.47
201 rdf:type schema:Person
202 sg:person.01133351543.21 schema:affiliation grid-institutes:grid.258799.8
203 schema:familyName Hishizawa
204 schema:givenName Masakatsu
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133351543.21
206 rdf:type schema:Person
207 sg:person.01227027220.06 schema:affiliation grid-institutes:grid.413697.e
208 schema:familyName Watanabe
209 schema:givenName Mitsumasa
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227027220.06
211 rdf:type schema:Person
212 sg:person.01242172154.57 schema:affiliation grid-institutes:grid.258799.8
213 schema:familyName Shindo
214 schema:givenName Takero
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242172154.57
216 rdf:type schema:Person
217 sg:person.01302524155.21 schema:affiliation grid-institutes:grid.258799.8
218 schema:familyName Nishikori
219 schema:givenName Momoko
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302524155.21
221 rdf:type schema:Person
222 sg:person.013732164761.79 schema:affiliation grid-institutes:grid.258799.8
223 schema:familyName Wada
224 schema:givenName Fumiya
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732164761.79
226 rdf:type schema:Person
227 sg:person.0666225507.36 schema:affiliation grid-institutes:grid.258799.8
228 schema:familyName Kondo
229 schema:givenName Tadakazu
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36
231 rdf:type schema:Person
232 sg:person.0721117322.46 schema:affiliation grid-institutes:grid.414936.d
233 schema:familyName Shimazu
234 schema:givenName Yayoi
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721117322.46
236 rdf:type schema:Person
237 sg:person.0743352217.37 schema:affiliation grid-institutes:grid.258799.8
238 schema:familyName Takaori-Kondo
239 schema:givenName Akifumi
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743352217.37
241 rdf:type schema:Person
242 sg:person.07506646357.42 schema:affiliation grid-institutes:grid.415392.8
243 schema:familyName Aiba
244 schema:givenName Akiko
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07506646357.42
246 rdf:type schema:Person
247 sg:pub.10.1007/s00280-019-03914-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120402965
248 https://doi.org/10.1007/s00280-019-03914-2
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s11912-019-0838-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120335693
251 https://doi.org/10.1007/s11912-019-0838-7
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s12185-009-0261-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027253340
254 https://doi.org/10.1007/s12185-009-0261-1
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/sj.bmt.1702658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010107542
257 https://doi.org/10.1038/sj.bmt.1702658
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/sj.bmt.1704073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029779862
260 https://doi.org/10.1038/sj.bmt.1704073
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/sj.bmt.1704574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042606831
263 https://doi.org/10.1038/sj.bmt.1704574
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/sj.bmt.1705758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043147565
266 https://doi.org/10.1038/sj.bmt.1705758
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/sj.bmt.1705820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025202013
269 https://doi.org/10.1038/sj.bmt.1705820
270 rdf:type schema:CreativeWork
271 grid-institutes:grid.258799.8 schema:alternateName Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
272 schema:name Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
273 rdf:type schema:Organization
274 grid-institutes:grid.413697.e schema:alternateName Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan
275 schema:name Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan
276 rdf:type schema:Organization
277 grid-institutes:grid.414936.d schema:alternateName Department of Hematology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan
278 schema:name Department of Hematology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan
279 rdf:type schema:Organization
280 grid-institutes:grid.415392.8 schema:alternateName Department of Hematology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
281 schema:name Department of Hematology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...