Safety and efficacy of anti-programmed cell death-1 monoclonal antibodies before and after allogeneic hematopoietic cell transplantation for relapsed or refractory ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-08-03

AUTHORS

Ayumu Ito, Sung-Won Kim, Ken-ichi Matsuoka, Toshiro Kawakita, Takashi Tanaka, Yoshihiro Inamoto, Tomomi Toubai, Shin-ichiro Fujiwara, Masafumi Fukaya, Tadakazu Kondo, Junichi Sugita, Miho Nara, Yuna Katsuoka, Yosuke Imai, Hideyuki Nakazawa, Ichiro Kawashima, Rika Sakai, Arata Ishii, Makoto Onizuka, Tomonari Takemura, Seitaro Terakura, Hiroatsu Iida, Mika Nakamae, Kohei Higuchi, Shinobu Tamura, Satoshi Yoshioka, Kazuto Togitani, Noriaki Kawano, Ritsuro Suzuki, Junji Suzumiya, Koji Izutsu, Takanori Teshima, Takahiro Fukuda

ABSTRACT

We conducted a multicenter study on anti-programmed cell death-1 monoclonal antibodies (anti-PD-1 mAbs) before/after allogeneic hematopoietic cell transplantation (allo-HCT) for Hodgkin lymphoma. Anti-PD-1 mAbs were administered to 25 patients before allo-HCT and to 20 after allo-HCT. In pre-allo-HCT setting, the median interval from the last administration to allo-HCT was 59 days. After allo-HCT, 12 patients developed non-infectious febrile syndrome requiring high-dose corticosteroid. The cumulative incidences of grade II–IV acute graft-versus-host disease (aGvHD) were 47.1%. Eight patients who had GvHD prophylaxis with post-transplant cyclophosphamide (PTCy) had less frequent aGvHD (grade II–IV, 14.6% versus 58.8%; P = 0.086). The 1 year overall survival (OS), relapse/progression, and non-relapse mortality rates were 81.3%, 27.9%, and 8.4%. In post-allo-HCT setting, the median interval from allo-HCT to the first administration was 589 days. The overall and complete response rates were 75% and 40%. At 100 days after anti-PD-1 therapy, the cumulative incidences of grade II–IV aGvHD, moderate-to-severe chronic GvHD, and grade 3–4 immune-related toxicity were 15.0%, 30.0%, and 30.0%. While the 1 year relapse/progression rate was 47.4%, the 1 year OS probability was 89.7%. In conclusion, immune-related complications were frequent despite modifications of GvHD prophylaxis or anti-PD-1 mAb dosing. In anti-PD-1-mAb-pretreated patients, PTCy-based GvHD prophylaxis may be effective. More... »

PAGES

674-689

References to SciGraph publications

  • 2017-08-15. Response to single agent PD-1 inhibitor after progression on previous PD-1/PD-L1 inhibitors: a case series in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2018-04-19. Retreatment with pembrolizumab in advanced non-small cell lung cancer patients previously treated with nivolumab: emerging reports of 12 cases in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2001-05-01. Engraftment syndrome following hematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • 2019-01-03. Relationship between clinical course of nivolumab-related myositis and immune status in a patient with Hodgkin’s lymphoma after allogeneic hematopoietic stem cell transplantation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2017-04-10. Nivolumab salvage therapy before or after allogeneic stem cell transplantation in Hodgkin lymphoma in BONE MARROW TRANSPLANTATION
  • 2016-05-16. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation in BONE MARROW TRANSPLANTATION
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2018-08-21. Severe immune-related complications early after allogeneic hematopoietic cell transplantation for nivolumab-pretreated lymphoma in BONE MARROW TRANSPLANTATION
  • 2016-01-04. Allogeneic hematopoietic stem cell transplantation in Hodgkin lymphoma: a systematic review and meta-analysis in BONE MARROW TRANSPLANTATION
  • Journal

    TITLE

    International Journal of Hematology

    ISSUE

    5

    VOLUME

    112

    Author Affiliations

  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
  • Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
  • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
  • Division of Hematology and Cell Therapy, Department of Internal Medicine III, Yamagata University Faculty of Medicine, Yamagata, Japan
  • Division of Hematology, Jichi Medical University Hospital, Shimotsuke, Japan
  • Department of Stem Cell Transplantation, Shizuoka Cancer Center, Nagaizumi, Japan
  • Department of Hematology, Kyoto University Hospital, Kyoto, Japan
  • Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
  • Department of Hematology, Akita University Hospital, Akita, Japan
  • Department of Hematology, National Hospital Organization Sendai Medical Center, Sendai, Japan
  • Department of Internal Medicine, Niigata Cancer Center Hospital, Niigata, Japan
  • Division of Hematology, Department of Internal Medicine, Shinshu University Hospital, Matsumoto, Japan
  • Department of Hematology and Oncology, Yamanashi University Hospital, Chuo, Japan
  • Department of Hematology and Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan
  • Department of Hematology, Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
  • Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan
  • Division of Hematology, Department of Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
  • Department of Hematology, Osaka City University Hospital, Osaka, Japan
  • Department of Hematology and Oncology, Osaka Women’s and Children’s Hospital, Izumi, Japan
  • Department of Hematology, Wakayama Medical University Hospital, Wakayama, Japan
  • Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
  • Department of Hematology, Kochi University Hospital, Kochi, Japan
  • Department of Hematology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan
  • Department of Oncology/Hematology, Shimane University Hospital, Izumo, Japan
  • Department of Hematology, National Cancer Center Hospital, Tokyo, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-020-02960-4

    DOI

    http://dx.doi.org/10.1007/s12185-020-02960-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1129847477

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32748216


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