Autologous hematopoietic cell transplantation for acute myeloid leukemia in adults: 25 years of experience in Japan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-10-14

AUTHORS

Masamitsu Yanada, Akiyoshi Takami, Shohei Mizuno, Jinichi Mori, Takaaki Chou, Kensuke Usuki, Hitoji Uchiyama, Itsuto Amano, Shiro Fujii, Toshihiro Miyamoto, Takeshi Saito, Tomohiko Kamimura, Tatsuo Ichinohe, Takahiro Fukuda, Shinichiro Okamoto, Yoshiko Atsuta, Shingo Yano

ABSTRACT

Autologous hematopoietic cell transplantation (HCT) has not gained universal popularity in the treatment of acute myeloid leukemia (AML), and its status remains unclear. To determine the implementation status and outcomes of autologous HCT for adults with AML in Japan, we analyzed data from 1,174 patients (including 446 with acute promyelocytic leukemia [APL]) who underwent autologous HCT between 1992 and 2016 consecutively reported to the Japanese nationwide transplantation registry. The annual number of transplantations peaked at 82 cases in 1997, and has recently remained at around 40 cases. The percentage of APL has increased sharply since 2004, and currently exceeds 70%. While most non-APL patients underwent autologous HCT during first complete remission (CR), transplantation during second CR has become mainstream for APL patients since the early 2000s. The 5-year survival, relapse, and non-relapse mortality rates were 55.3%, 42.1%, and 8.6% for non-APL patients, and 87.6%, 12.9%, and 3.4% for APL patients, respectively. Patients transplanted in the later period showed better survival than those transplanted in the earlier period, both for non-APL (P < 0.001) and APL (P = 0.036). These results clearly show the various changes in transplantation practice and post-transplant outcomes in Japan over the past 25 years. More... »

PAGES

93-102

References to SciGraph publications

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  • Journal

    TITLE

    International Journal of Hematology

    ISSUE

    1

    VOLUME

    111

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-019-02759-y

    DOI

    http://dx.doi.org/10.1007/s12185-019-02759-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1121783554

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31612307


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