Global coagulation function assessed by rotational thromboelastometry predicts coagulation-steady state in individual hemophilia A patients receiving emicizumab prophylaxis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06-28

AUTHORS

Koji Yada, Keiji Nogami, Kenichi Ogiwara, Yasuaki Shida, Shoko Furukawa, Hiroaki Yaoi, Masahiro Takeyama, Ryu Kasai, Midori Shima

ABSTRACT

Emicizumab is a bispecific antibody to factor (F) IX/IXa and FX/FXa, which mimics FVIIIa cofactor function. Emicizumab prophylaxis significantly decreases bleeding events for patients with hemophilia A (PwHA). However, global hemostatic monitoring in emicizumab-treated PwHA remains poorly investigated. Using rotational thromboelastometry (ROTEM), we evaluated coagulation potentials of whole blood samples from seven emicizumab-treated PwHA who participated in ACE001JP/ACE002JP studies. Dose-dependent coagulation-enhancing effects of emicizumab to whole blood from PwHA mixed with an anti-FVIII C2 antibody in vitro were evident by non-activated ROTEM analysis (NATEM). The relationship between FVIII levels and NATEM parameters in PwHA not participating in the clinical trials demonstrated that CT + CFT inversely correlated with FVIII levels. These parameters were defined as NATEM-based grading of coagulation potential; ‘T1’ (FVIII < 1 IU/dL), ‘T2’ (1 ≤ , < 12 IU/dL) and ‘T3’ (12 ≤ , < 60 IU/dL). Coagulation function in emicizumab-treated PwHA was determined to be ‘T2’ or ‘T3,’ and was dependent on plasma emicizumab concentration. Improvement of NATEM-based grades corresponded with significant reduction of bleeding episodes, except for target joints, and differences were due to the time to reach the coagulation-steady state in individual patients. The NATEM analysis may be useful for intra- and inter-individual evaluation of coagulation function in emicizumab-treated PwHA. More... »

PAGES

419-430

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-019-02698-8

DOI

http://dx.doi.org/10.1007/s12185-019-02698-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117615552

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31254165


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