Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with hepatitis-associated aplastic anemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-08

AUTHORS

Takehiko Mori, Yasushi Onishi, Yukiyasu Ozawa, Chiaki Kato, Tatsuyuki Kai, Yoshinobu Kanda, Mineo Kurokawa, Masatsugu Tanaka, Takashi Ashida, Yasushi Sawayama, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Hirohito Yamazaki

ABSTRACT

Outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) for hepatitis-associated aplastic anemia have not been fully evaluated. In the present study, the outcomes of 37 adult patients with hepatitis-associated aplastic anemia who underwent allogeneic HSCT were retrospectively analyzed using the registry database of Japan Society for Hematopoietic Cell Transplantation. The median age of the patients was 24 years (range, 16–61). The median period between diagnosis of hepatitis-associated aplastic anemia and HSCT was 6.0 months (range, 0.5–430.8). Stem cell sources were bone marrow (N = 19) or peripheral blood stem cells (N = 5) from an HLA-identical sibling or bone marrow (N = 11) and cord blood (N = 2) from an unrelated donor. The majority of conditioning regimens were fludarabine-based or high-dose cyclophosphamide-based. In all but 2 cases of early death, neutrophil engraftment was achieved. At the time of analysis, 32 patients were alive, with a median follow-up of 54.1 months. Five-year overall and failure-free survival rates were 86.0% (95% CI, 69.4–93.9%) and 75.0% (95% CI, 57.4–86.2%), respectively. Despite the heterogeneity in transplant procedures in a small number of patients, these results suggest that allogeneic HSCT is safe for use in hepatitis-associated aplastic anemia with a low rate of transplant-related mortality. More... »

PAGES

711-717

Journal

TITLE

International Journal of Hematology

ISSUE

6

VOLUME

109

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-019-02644-8

DOI

http://dx.doi.org/10.1007/s12185-019-02644-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113301203

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30963471


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27 schema:description Outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) for hepatitis-associated aplastic anemia have not been fully evaluated. In the present study, the outcomes of 37 adult patients with hepatitis-associated aplastic anemia who underwent allogeneic HSCT were retrospectively analyzed using the registry database of Japan Society for Hematopoietic Cell Transplantation. The median age of the patients was 24 years (range, 16–61). The median period between diagnosis of hepatitis-associated aplastic anemia and HSCT was 6.0 months (range, 0.5–430.8). Stem cell sources were bone marrow (N = 19) or peripheral blood stem cells (N = 5) from an HLA-identical sibling or bone marrow (N = 11) and cord blood (N = 2) from an unrelated donor. The majority of conditioning regimens were fludarabine-based or high-dose cyclophosphamide-based. In all but 2 cases of early death, neutrophil engraftment was achieved. At the time of analysis, 32 patients were alive, with a median follow-up of 54.1 months. Five-year overall and failure-free survival rates were 86.0% (95% CI, 69.4–93.9%) and 75.0% (95% CI, 57.4–86.2%), respectively. Despite the heterogeneity in transplant procedures in a small number of patients, these results suggest that allogeneic HSCT is safe for use in hepatitis-associated aplastic anemia with a low rate of transplant-related mortality.
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34 HLA-identical siblings
35 Japan Society
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37 adult patients
38 age
39 allogeneic hematopoietic stem cell transplantation
40 analysis
41 anemia
42 aplastic anemia
43 blood
44 blood stem cells
45 bone marrow
46 cases
47 cell source
48 cell transplantation
49 cells
50 conditioning regimens
51 cord blood
52 database
53 death
54 diagnosis
55 donors
56 early death
57 engraftment
58 failure-free survival rate
59 hematopoietic cell transplantation
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61 hepatitis
62 hepatitis-associated aplastic anemia
63 heterogeneity
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66 marrow
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