Glucocorticoids promote response to thrombopoietin-receptor agonists in refractory ITP: a case series. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-10

AUTHORS

Jacqueline N Poston, Terry B Gernsheimer

ABSTRACT

A proportion of patients with immune thrombocytopenic purpura are refractory to multiple therapies including thrombopoietin-receptor agonists (TPO-RA). We report 10 patients who did not respond to a TPO-RA until the addition of a glucocorticoid. These patients were previously treated with a median of 6 therapies. One patient elected to discontinue both medications despite persistent thrombocytopenia. The remaining 9 patients continued on the combination of prednisone (doses 5 mg every other day to 10 mg daily) and a TPO-RA. Combination therapy with low dose glucocorticoid and a TPO-RA may be an option for patients unresponsive to a TPO-RA alone. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-019-02638-6

DOI

http://dx.doi.org/10.1007/s12185-019-02638-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113356324

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30972617


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