Light-chain plasma cell myeloma caused by 14q32/IGH translocation and loss of the other allele View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-18

AUTHORS

Yuji Nishio, Hirotaka Sakai, Yusuke Saiki, Akiko Uchida, Yu Uemura, Manabu Matsunawa, Yasushi Isobe, Masayuki Kato, Naoto Tomita, Ikuo Miura

ABSTRACT

Light-chain plasma cell myeloma (LC-PCM) is a PCM subtype in which only immunoglobulin light-chain is secreted. However, the absence of immunoglobulin heavy-chain (IGH) production in this condition has not been fully elucidated. To address this issue, we retrospectively analyzed patients at our center with LC-PCM and found a group who had only split signals of IGH gene derived from 14q32/IGH translocations by fluorescence in situ hybridization (FISH). Six patients were identified with only split signals of the IGH gene derived from 14q32/IGH translocations. Five of these patients were newly diagnosed, while one had IgG-λ PCM at presentation, which transformed to λ LC-PCM after treatment. The translocation partners were identified in four patients: two cases of (11;14)(q13;q32) and two cases of (4;14)(p16;q32). The development of LC-PCM appears to be explained by the application of allelic exclusion in these patients, such that 14q32/IGH translocation in one allele contributes to the pathogenesis of PCM and the subsequent loss of the other allele is responsible for the loss of IGH production. These findings suggest that a FISH pattern of IGH with “split and loss” may constitute a unique subgroup of LC-PCM. More... »

PAGES

572-577

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-019-02629-7

DOI

http://dx.doi.org/10.1007/s12185-019-02629-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112857763

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30887274


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