Risk factors and survival impact of readmission after single-unit cord blood transplantation for adults View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10-09

AUTHORS

Yasuko Yamagishi, Takaaki Konuma, Yoriko Miwa, Maki Oiwa-Monna, Susumu Tanoue, Masamichi Isobe, Koji Jimbo, Mai Mizusawa, Hatsuko Narita, Koji Kobayashi, Seiko Kato, Satoshi Takahashi, Arinobu Tojo

ABSTRACT

Hospital readmissions have been used as a prognostic indicator for patients receiving allogeneic hematopoietic cell transplantation (HCT). However, the impact of readmission during early and mid-phase of cord blood transplantation (CBT) on long-term outcomes has not been fully investigated. We retrospectively analyzed 156 adult patients who received single-unit CBT in our institute. Among this cohort, thirteen patients (8%) were readmitted within 30 days after discharge, and 27 (17%) were readmitted within 90 days after discharge. The most common causes for readmission within 30 and 90 days of discharge were infection, chronic graft-versus-host disease, and relapse. Higher cryopreserved cord blood CD34+ cell count was only significantly associated with lower readmission within 90 days after discharge. The probabilities of overall survival were significantly lower in patients readmitted within 90 days after discharge compared with those who were not readmitted within 90 days after discharge in univariate and multivariate analysis. These data suggest that readmission within 90 days after discharge may have a significant impact on long-term mortality after single-unit CBT. More... »

PAGES

115-124

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-018-2539-7

DOI

http://dx.doi.org/10.1007/s12185-018-2539-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107499468

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30302739


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