Plerixafor for mobilization and collection of haematopoietic stem cells for autologous transplantation in Japanese patients with non-Hodgkin lymphoma: a randomized ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

Kosei Matsue, Kyoya Kumagai, Isamu Sugiura, Takayuki Ishikawa, Tadahiko Igarashi, Tsutomu Sato, Michihiro Uchiyama, Toshihiro Miyamoto, Takaaki Ono, Yasunori Ueda, Toru Kiguchi, Yoshinori Sunaga, Toru Sasaki, Kenshi Suzuki

ABSTRACT

The present study (ClinicalTrials.gov Identifier: NCT02221492) was conducted to assess the efficacy and safety of plerixafor for the mobilization and collection of haematopoietic stem cells (HSCs) for autologous transplantation in Japanese non-Hodgkin lymphoma (NHL) patients. In this randomized phase 2 study, patients received granulocyte-colony stimulating factor (G-CSF, filgrastim) 400 µg/m²/day for up to 8 days. Starting on the evening of day 4, patients received, for up to 4 days, either plerixafor (240 µg/kg/day) in the G-CSF+ plerixafor arm (GP arm) or G-CSF alone arm (G arm). On day 5, daily apheresis started and was continued for up to 4 days, or until ≥ 5 × 106 CD34+ cells/kg was collected. A total of 32 patients were randomized to either the GP or G arm. In the GP arm, 9/16 patients (56.3%) achieved collection of ≥ 5 × 106 CD34+ cells/kg in ≤ 4 days of apheresis, while 1/16 patient (6.3%) achieved this target in the G arm. The most common treatment-emergent adverse events in the GP arm were back pain (56.3%), platelet count decreased (25.0%), headache, diarrhoea, and nausea (18.8% each). We found that plerixafor was well tolerated and effective for the mobilization and collection of peripheral HSCs for autologous transplantation in Japanese NHL patients. More... »

PAGES

524-534

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-018-2505-4

DOI

http://dx.doi.org/10.1007/s12185-018-2505-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105773467

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30043330


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