Efficacy and safety of obinutuzumab in patients with previously untreated follicular lymphoma: a subgroup analysis of patients enrolled in Japan ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

Ken Ohmachi, Kensei Tobinai, Tomohiro Kinoshita, Takayuki Ishikawa, Kiyohiko Hatake, Satoshi Ichikawa, Ken Ohmine, Yuri Kamitsuji, Ilseung Choi, Takaaki Chou, Kunihiro Tsukasaki, Kyoya Kumagai, Masafumi Taniwaki, Toshiki Uchida, Yoshitaka Kikukawa, Kohmei Kubo, Keichiro Mihara, Norifumi Tsukamoto, Koji Izutsu, Isao Yoshida, Fumihiro Ishida, Noriko Usui, Shinsuke Iida, Tohru Murayama, Eisuke Ueda, Hiroshi Kuriki, Kiyoshi Ando

ABSTRACT

GALLIUM is a global phase III study that demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) with obinutuzumab plus chemotherapy (G-chemo) versus rituximab plus chemotherapy (R-chemo) in previously untreated patients with follicular lymphoma (FL). In this single-country subgroup analysis, we explored patterns of efficacy and safety in patients enrolled in the GALLIUM study in Japan (Japanese subgroup). Patients were randomized to open-label induction treatment with G-chemo or R-chemo. Responders received maintenance monotherapy with their randomized antibody for up to 2 years. The primary endpoint was investigator-assessed PFS. Overall, 123 patients with FL were randomized in the Japanese subgroup (G-chemo, n = 65; R-chemo, n = 58). The majority of patients received cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (82.9 vs 33.1% in the global GALLIUM FL population). PFS at 3 years was 89.9% (G-chemo) vs. 74.7% (R-chemo); hazard ratio 0.42; 95% confidence interval 0.15, 1.15; P = 0.08. Higher rates of grade 3-5 adverse events (96.9 vs. 89.7%) and serious adverse events (35.4 vs. 22.4%) were observed with G-chemo vs R-chemo, respectively. Neutropenia was frequent in the Japanese subgroup (92.3% G-chemo; 79.3% R-chemo). Overall, the results in the Japanese subgroup were consistent with those in the global GALLIUM population. More... »

PAGES

499-509

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-018-2497-0

DOI

http://dx.doi.org/10.1007/s12185-018-2497-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105708938

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30027429


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Follicular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rituximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohmachi", 
        "givenName": "Ken", 
        "id": "sg:person.01321520521.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321520521.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tobinai", 
        "givenName": "Kensei", 
        "id": "sg:person.01210303461.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210303461.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Aichi Cancer Center, Nagoya, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinoshita", 
        "givenName": "Tomohiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kobe City Medical Center General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410843.a", 
          "name": [
            "Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishikawa", 
        "givenName": "Takayuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Cancer Institute Hospital", 
          "id": "https://www.grid.ac/institutes/grid.486756.e", 
          "name": [
            "The Cancer Institute Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hatake", 
        "givenName": "Kiyohiko", 
        "id": "sg:person.01252161657.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252161657.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichikawa", 
        "givenName": "Satoshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Jichi Medical University, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohmine", 
        "givenName": "Ken", 
        "id": "sg:person.01144457051.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144457051.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Matsushita Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416591.e", 
          "name": [
            "Matsushita Memorial Hospital, Moriguchi, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamitsuji", 
        "givenName": "Yuri", 
        "id": "sg:person.01057450233.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057450233.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Hospital Organization Kyushu Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.470350.5", 
          "name": [
            "National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Ilseung", 
        "id": "sg:person.0745256126.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745256126.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Niigata Cancer Center Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416203.2", 
          "name": [
            "Niigata Cancer Center Hospital, Niigata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chou", 
        "givenName": "Takaaki", 
        "id": "sg:person.01074747373.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074747373.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "National Cancer Center Hospital East, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsukasaki", 
        "givenName": "Kunihiro", 
        "id": "sg:person.01356462526.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356462526.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.418490.0", 
          "name": [
            "Chiba Cancer Center, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumagai", 
        "givenName": "Kyoya", 
        "id": "sg:person.01013061517.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013061517.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto Prefectural University of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Kyoto Prefectural University of Medicine, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taniwaki", 
        "givenName": "Masafumi", 
        "id": "sg:person.01320436003.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320436003.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japanese Red Cross Nagoya Daini Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413410.3", 
          "name": [
            "Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchida", 
        "givenName": "Toshiki", 
        "id": "sg:person.01332044324.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332044324.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kumamoto University", 
          "id": "https://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Kumamoto University Graduate School of Medicine, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kikukawa", 
        "givenName": "Yoshitaka", 
        "id": "sg:person.0676267123.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676267123.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aomori Prefectural Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413825.9", 
          "name": [
            "Aomori Prefectural Central Hospital, Aomori, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kubo", 
        "givenName": "Kohmei", 
        "id": "sg:person.07565420012.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07565420012.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.470097.d", 
          "name": [
            "Hiroshima University Hospital, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mihara", 
        "givenName": "Keichiro", 
        "id": "sg:person.0651040257.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651040257.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gunma University", 
          "id": "https://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsukamoto", 
        "givenName": "Norifumi", 
        "id": "sg:person.01364745540.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364745540.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toranomon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410813.f", 
          "name": [
            "Toranomon Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Izutsu", 
        "givenName": "Koji", 
        "id": "sg:person.01277263470.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277263470.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shikoku Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.415740.3", 
          "name": [
            "National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Isao", 
        "id": "sg:person.01351454103.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351454103.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shinshu University", 
          "id": "https://www.grid.ac/institutes/grid.263518.b", 
          "name": [
            "Shinshu University School of Medicine, Nagano, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishida", 
        "givenName": "Fumihiro", 
        "id": "sg:person.0601706771.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601706771.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jikei University", 
          "id": "https://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "The Jikei University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Usui", 
        "givenName": "Noriko", 
        "id": "sg:person.01114721672.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114721672.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iida", 
        "givenName": "Shinsuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hyogo Prefectural Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.417755.5", 
          "name": [
            "Hyogo Cancer Center, Akashi, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murayama", 
        "givenName": "Tohru", 
        "id": "sg:person.01313325643.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313325643.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.418587.7", 
          "name": [
            "Chugai Pharmaceutical Co., Ltd., Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Eisuke", 
        "id": "sg:person.014166016450.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014166016450.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.418587.7", 
          "name": [
            "Chugai Pharmaceutical Co., Ltd., Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuriki", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01221635531.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221635531.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ando", 
        "givenName": "Kiyoshi", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3960/jslrt.54.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004420388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-016-2097-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013414658", 
          "https://doi.org/10.1007/s12185-016-2097-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-016-2097-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013414658", 
          "https://doi.org/10.1007/s12185-016-2097-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1313984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014014595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1102/1470-7330.2005.0038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015440550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-3026(14)70008-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018494472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-12-1182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019564994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-01-0016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019752393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.12659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026338058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-01-481341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026442210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-12-4434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027887474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(16)30097-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028366269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2016-06-718544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028625516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-04-153189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029707044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-08-3175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033024465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.06.4618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034611434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-06-225979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039920012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12325-016-0451-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043698358", 
          "https://doi.org/10.1007/s12325-016-0451-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12325-016-0451-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043698358", 
          "https://doi.org/10.1007/s12325-016-0451-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.2403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045509899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02982692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046125242", 
          "https://doi.org/10.1007/bf02982692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02982692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046125242", 
          "https://doi.org/10.1007/bf02982692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.3.1110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083057227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083095803", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-017-3747-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085615092", 
          "https://doi.org/10.1007/s00520-017-3747-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-017-3747-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085615092", 
          "https://doi.org/10.1007/s00520-017-3747-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hon.2437_20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085906729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1614598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092089645"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-11", 
    "datePublishedReg": "2018-11-01", 
    "description": "GALLIUM is a global phase III study that demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) with obinutuzumab plus chemotherapy (G-chemo) versus rituximab plus chemotherapy (R-chemo) in previously untreated patients with follicular lymphoma (FL). In this single-country subgroup analysis, we explored patterns of efficacy and safety in patients enrolled in the GALLIUM study in Japan (Japanese subgroup). Patients were randomized to open-label induction treatment with G-chemo or R-chemo. Responders received maintenance monotherapy with their randomized antibody for up to 2\u00a0years. The primary endpoint was investigator-assessed PFS. Overall, 123 patients with FL were randomized in the Japanese subgroup (G-chemo, n\u2009=\u200965; R-chemo, n\u2009=\u200958). The majority of patients received cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (82.9 vs 33.1% in the global GALLIUM FL population). PFS at 3\u00a0years was 89.9% (G-chemo) vs. 74.7% (R-chemo); hazard ratio 0.42; 95% confidence interval 0.15, 1.15; P\u2009=\u20090.08. Higher rates of grade 3-5 adverse events (96.9 vs. 89.7%) and serious adverse events (35.4 vs. 22.4%) were observed with G-chemo vs R-chemo, respectively. Neutropenia was frequent in the Japanese subgroup (92.3% G-chemo; 79.3% R-chemo). Overall, the results in the Japanese subgroup were consistent with those in the global GALLIUM population.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12185-018-2497-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1076985", 
        "issn": [
          "0925-5710", 
          "1865-3774"
        ], 
        "name": "International Journal of Hematology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "108"
      }
    ], 
    "name": "Efficacy and safety of obinutuzumab in patients with previously untreated follicular lymphoma: a subgroup analysis of patients enrolled in Japan in the randomized phase III GALLIUM trial", 
    "pagination": "499-509", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a7fce0ae4fcd1f312f1a8bc6cb8e3a3ddfde2320851e7fd1119695ca6f5549e1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30027429"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9111627"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12185-018-2497-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105708938"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12185-018-2497-0", 
      "https://app.dimensions.ai/details/publication/pub.1105708938"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000573.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12185-018-2497-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2497-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2497-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2497-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2497-0'


 

This table displays all metadata directly associated to this object as RDF triples.

443 TRIPLES      21 PREDICATES      66 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12185-018-2497-0 schema:about N0611402009b04e99b56b6297ffb2fc53
2 N1221d3ebbd81443390af47192f28aa78
3 N2bf5d7b77fd44c7d91963e94f171c197
4 N4303e2c86d334360b343cbdb26574df5
5 N46ae6227437743c89466089d85ae52e2
6 N4a28aac984ec4d28b5f3b94720d718c6
7 N5789fab25fd449aeb556292077e463d3
8 N7f756feffcf6406489cc1a90e187d98f
9 N8c89165aee8a410d91c6519c77135c4e
10 Naff7951ee24d4a1998c784b2ae94a1f5
11 Nb70e4adf878e4c11b9799a6d601beb75
12 Nb7e5727a97e44649a6e3cfc6e349e093
13 Nd42e300f865044f18660d190db8b571a
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N9f642a4fa4ca4f64a5f3cc7765755013
17 schema:citation sg:pub.10.1007/bf02982692
18 sg:pub.10.1007/s00520-017-3747-z
19 sg:pub.10.1007/s12185-016-2097-9
20 sg:pub.10.1007/s12325-016-0451-1
21 https://app.dimensions.ai/details/publication/pub.1083095803
22 https://doi.org/10.1002/hon.2437_20
23 https://doi.org/10.1016/s1470-2045(16)30097-3
24 https://doi.org/10.1016/s2352-3026(14)70008-0
25 https://doi.org/10.1056/nejmoa1313984
26 https://doi.org/10.1056/nejmoa1614598
27 https://doi.org/10.1102/1470-7330.2005.0038
28 https://doi.org/10.1111/bjh.12659
29 https://doi.org/10.1158/1535-7163.mct-12-1182
30 https://doi.org/10.1182/blood-2003-12-4434
31 https://doi.org/10.1182/blood-2004-08-3175
32 https://doi.org/10.1182/blood-2005-01-0016
33 https://doi.org/10.1182/blood-2008-04-153189
34 https://doi.org/10.1182/blood-2009-06-225979
35 https://doi.org/10.1182/blood-2013-01-481341
36 https://doi.org/10.1182/blood-2016-06-718544
37 https://doi.org/10.1200/jco.1997.15.3.1110
38 https://doi.org/10.1200/jco.2006.06.4618
39 https://doi.org/10.1200/jco.2006.09.2403
40 https://doi.org/10.3960/jslrt.54.31
41 schema:datePublished 2018-11
42 schema:datePublishedReg 2018-11-01
43 schema:description GALLIUM is a global phase III study that demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) with obinutuzumab plus chemotherapy (G-chemo) versus rituximab plus chemotherapy (R-chemo) in previously untreated patients with follicular lymphoma (FL). In this single-country subgroup analysis, we explored patterns of efficacy and safety in patients enrolled in the GALLIUM study in Japan (Japanese subgroup). Patients were randomized to open-label induction treatment with G-chemo or R-chemo. Responders received maintenance monotherapy with their randomized antibody for up to 2 years. The primary endpoint was investigator-assessed PFS. Overall, 123 patients with FL were randomized in the Japanese subgroup (G-chemo, n = 65; R-chemo, n = 58). The majority of patients received cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (82.9 vs 33.1% in the global GALLIUM FL population). PFS at 3 years was 89.9% (G-chemo) vs. 74.7% (R-chemo); hazard ratio 0.42; 95% confidence interval 0.15, 1.15; P = 0.08. Higher rates of grade 3-5 adverse events (96.9 vs. 89.7%) and serious adverse events (35.4 vs. 22.4%) were observed with G-chemo vs R-chemo, respectively. Neutropenia was frequent in the Japanese subgroup (92.3% G-chemo; 79.3% R-chemo). Overall, the results in the Japanese subgroup were consistent with those in the global GALLIUM population.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf N1d7b747d21a34cedad4681d27b026d4b
48 Nce378a26c38945a3bd107bda81e526e9
49 sg:journal.1076985
50 schema:name Efficacy and safety of obinutuzumab in patients with previously untreated follicular lymphoma: a subgroup analysis of patients enrolled in Japan in the randomized phase III GALLIUM trial
51 schema:pagination 499-509
52 schema:productId N0a0142172f8e46d99819764fbe22c3ce
53 N5cb9e61f087d40bb969618b47d9e0486
54 N7ae97014494a493f97ceb9061ffda7a7
55 Ncedb20c712e74c31841b7fea28b6ba9c
56 Nf33f7c9bbb6e42edb6dc3ef7bfb70e15
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105708938
58 https://doi.org/10.1007/s12185-018-2497-0
59 schema:sdDatePublished 2019-04-10T15:11
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N1996cb669d444bcf9997c30aaf4af40a
62 schema:url https://link.springer.com/10.1007%2Fs12185-018-2497-0
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N0028c0a350b747d3873c08dd9a20c383 rdf:first sg:person.01144457051.28
67 rdf:rest N4be51a577e6043f1bcd50fac5e766bb6
68 N0611402009b04e99b56b6297ffb2fc53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Disease-Free Survival
70 rdf:type schema:DefinedTerm
71 N0a0142172f8e46d99819764fbe22c3ce schema:name pubmed_id
72 schema:value 30027429
73 rdf:type schema:PropertyValue
74 N0df5b1348aff42debe8424494db6a660 schema:affiliation https://www.grid.ac/institutes/grid.410843.a
75 schema:familyName Ishikawa
76 schema:givenName Takayuki
77 rdf:type schema:Person
78 N1221d3ebbd81443390af47192f28aa78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Japan
80 rdf:type schema:DefinedTerm
81 N1996cb669d444bcf9997c30aaf4af40a schema:name Springer Nature - SN SciGraph project
82 rdf:type schema:Organization
83 N1d7b747d21a34cedad4681d27b026d4b schema:issueNumber 5
84 rdf:type schema:PublicationIssue
85 N273b3a0af82440789807f4100ee81e78 rdf:first sg:person.01210303461.01
86 rdf:rest Ne08be25e736c47feb051154c6e278d9a
87 N2bf5d7b77fd44c7d91963e94f171c197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Middle Aged
89 rdf:type schema:DefinedTerm
90 N36b120253ff547c0a42ca00e2149aa94 rdf:first sg:person.01221635531.46
91 rdf:rest Ncb34634010ac411a9f2e0d6a3baa872c
92 N3ad03727cf2a4e09915659df73472fe6 rdf:first sg:person.0676267123.41
93 rdf:rest Neeaa71fde37643418cf91c1ecffa83e5
94 N3f47f2b92b184213b11cba80a99274ec rdf:first sg:person.01332044324.88
95 rdf:rest N3ad03727cf2a4e09915659df73472fe6
96 N4303e2c86d334360b343cbdb26574df5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Survival Rate
98 rdf:type schema:DefinedTerm
99 N46ae6227437743c89466089d85ae52e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Lymphoma, Follicular
101 rdf:type schema:DefinedTerm
102 N48761f267d054beba6dfe64240fe80a3 rdf:first sg:person.01356462526.00
103 rdf:rest N9d0faa31dd8f410c96c5b7e441191ea1
104 N4a28aac984ec4d28b5f3b94720d718c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Antibodies, Monoclonal, Humanized
106 rdf:type schema:DefinedTerm
107 N4b5850fee5374e1db6faf8d4e12fa619 schema:affiliation https://www.grid.ac/institutes/grid.410800.d
108 schema:familyName Kinoshita
109 schema:givenName Tomohiro
110 rdf:type schema:Person
111 N4be51a577e6043f1bcd50fac5e766bb6 rdf:first sg:person.01057450233.47
112 rdf:rest Nba996f6eca274397b57a053b8fc1b83f
113 N51ab20dfc86d4c37b1bfcfbc55696e0a rdf:first N98d94d3ebdc146528dedfa74659bda80
114 rdf:rest N73574884851146499a06bce31e131898
115 N5789fab25fd449aeb556292077e463d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Aged
117 rdf:type schema:DefinedTerm
118 N5cb9e61f087d40bb969618b47d9e0486 schema:name dimensions_id
119 schema:value pub.1105708938
120 rdf:type schema:PropertyValue
121 N69bc53ac79054e9095bea719d7f49d05 rdf:first sg:person.0601706771.30
122 rdf:rest Nd6e475603f5b4a33bd39d2834d080229
123 N73574884851146499a06bce31e131898 rdf:first sg:person.01313325643.14
124 rdf:rest Nee529c849e5d4e4c921bc44a31dc60f4
125 N73b7e3173fa04c28bbb31ee74e966238 rdf:first sg:person.01364745540.48
126 rdf:rest Nee1451a896034559811c340704cdc22e
127 N74a023cc9ae44b5b91177ec0b1cba0fc schema:affiliation https://www.grid.ac/institutes/grid.265061.6
128 schema:familyName Ando
129 schema:givenName Kiyoshi
130 rdf:type schema:Person
131 N7a59ff3198a4454db90620b86b4a89f1 rdf:first sg:person.01074747373.78
132 rdf:rest N48761f267d054beba6dfe64240fe80a3
133 N7ae97014494a493f97ceb9061ffda7a7 schema:name doi
134 schema:value 10.1007/s12185-018-2497-0
135 rdf:type schema:PropertyValue
136 N7f756feffcf6406489cc1a90e187d98f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Humans
138 rdf:type schema:DefinedTerm
139 N7fce079b2f704d379a06ddcfb665e621 rdf:first sg:person.01320436003.92
140 rdf:rest N3f47f2b92b184213b11cba80a99274ec
141 N8a663c3bda39483cb43836ee2e403764 rdf:first sg:person.01252161657.78
142 rdf:rest N9e3877bb2003476b898778b735242e59
143 N8c89165aee8a410d91c6519c77135c4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Female
145 rdf:type schema:DefinedTerm
146 N97dbacf212ac43c6a7a3c4cef8d6742b rdf:first sg:person.01351454103.34
147 rdf:rest N69bc53ac79054e9095bea719d7f49d05
148 N98d94d3ebdc146528dedfa74659bda80 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
149 schema:familyName Iida
150 schema:givenName Shinsuke
151 rdf:type schema:Person
152 N9d0faa31dd8f410c96c5b7e441191ea1 rdf:first sg:person.01013061517.65
153 rdf:rest N7fce079b2f704d379a06ddcfb665e621
154 N9e3877bb2003476b898778b735242e59 rdf:first N9e6ee61e8cde4c928a572671105d2b7b
155 rdf:rest N0028c0a350b747d3873c08dd9a20c383
156 N9e6ee61e8cde4c928a572671105d2b7b schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
157 schema:familyName Ichikawa
158 schema:givenName Satoshi
159 rdf:type schema:Person
160 N9f642a4fa4ca4f64a5f3cc7765755013 rdf:first sg:person.01321520521.34
161 rdf:rest N273b3a0af82440789807f4100ee81e78
162 Naff7951ee24d4a1998c784b2ae94a1f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adult
164 rdf:type schema:DefinedTerm
165 Nb4e3b7f00cd8400e96e174218ea554f4 rdf:first sg:person.0651040257.65
166 rdf:rest N73b7e3173fa04c28bbb31ee74e966238
167 Nb70e4adf878e4c11b9799a6d601beb75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Male
169 rdf:type schema:DefinedTerm
170 Nb7e5727a97e44649a6e3cfc6e349e093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Antineoplastic Combined Chemotherapy Protocols
172 rdf:type schema:DefinedTerm
173 Nba996f6eca274397b57a053b8fc1b83f rdf:first sg:person.0745256126.40
174 rdf:rest N7a59ff3198a4454db90620b86b4a89f1
175 Nc2335dad7b6b42dba06e8d83647edb82 rdf:first N0df5b1348aff42debe8424494db6a660
176 rdf:rest N8a663c3bda39483cb43836ee2e403764
177 Ncb34634010ac411a9f2e0d6a3baa872c rdf:first N74a023cc9ae44b5b91177ec0b1cba0fc
178 rdf:rest rdf:nil
179 Nce378a26c38945a3bd107bda81e526e9 schema:volumeNumber 108
180 rdf:type schema:PublicationVolume
181 Ncedb20c712e74c31841b7fea28b6ba9c schema:name nlm_unique_id
182 schema:value 9111627
183 rdf:type schema:PropertyValue
184 Nd42e300f865044f18660d190db8b571a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Rituximab
186 rdf:type schema:DefinedTerm
187 Nd6e475603f5b4a33bd39d2834d080229 rdf:first sg:person.01114721672.90
188 rdf:rest N51ab20dfc86d4c37b1bfcfbc55696e0a
189 Ne08be25e736c47feb051154c6e278d9a rdf:first N4b5850fee5374e1db6faf8d4e12fa619
190 rdf:rest Nc2335dad7b6b42dba06e8d83647edb82
191 Nee1451a896034559811c340704cdc22e rdf:first sg:person.01277263470.36
192 rdf:rest N97dbacf212ac43c6a7a3c4cef8d6742b
193 Nee529c849e5d4e4c921bc44a31dc60f4 rdf:first sg:person.014166016450.56
194 rdf:rest N36b120253ff547c0a42ca00e2149aa94
195 Neeaa71fde37643418cf91c1ecffa83e5 rdf:first sg:person.07565420012.12
196 rdf:rest Nb4e3b7f00cd8400e96e174218ea554f4
197 Nf33f7c9bbb6e42edb6dc3ef7bfb70e15 schema:name readcube_id
198 schema:value a7fce0ae4fcd1f312f1a8bc6cb8e3a3ddfde2320851e7fd1119695ca6f5549e1
199 rdf:type schema:PropertyValue
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
204 schema:name Oncology and Carcinogenesis
205 rdf:type schema:DefinedTerm
206 sg:journal.1076985 schema:issn 0925-5710
207 1865-3774
208 schema:name International Journal of Hematology
209 rdf:type schema:Periodical
210 sg:person.01013061517.65 schema:affiliation https://www.grid.ac/institutes/grid.418490.0
211 schema:familyName Kumagai
212 schema:givenName Kyoya
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013061517.65
214 rdf:type schema:Person
215 sg:person.01057450233.47 schema:affiliation https://www.grid.ac/institutes/grid.416591.e
216 schema:familyName Kamitsuji
217 schema:givenName Yuri
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057450233.47
219 rdf:type schema:Person
220 sg:person.01074747373.78 schema:affiliation https://www.grid.ac/institutes/grid.416203.2
221 schema:familyName Chou
222 schema:givenName Takaaki
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074747373.78
224 rdf:type schema:Person
225 sg:person.01114721672.90 schema:affiliation https://www.grid.ac/institutes/grid.411898.d
226 schema:familyName Usui
227 schema:givenName Noriko
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114721672.90
229 rdf:type schema:Person
230 sg:person.01144457051.28 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
231 schema:familyName Ohmine
232 schema:givenName Ken
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144457051.28
234 rdf:type schema:Person
235 sg:person.01210303461.01 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
236 schema:familyName Tobinai
237 schema:givenName Kensei
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210303461.01
239 rdf:type schema:Person
240 sg:person.01221635531.46 schema:affiliation https://www.grid.ac/institutes/grid.418587.7
241 schema:familyName Kuriki
242 schema:givenName Hiroshi
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221635531.46
244 rdf:type schema:Person
245 sg:person.01252161657.78 schema:affiliation https://www.grid.ac/institutes/grid.486756.e
246 schema:familyName Hatake
247 schema:givenName Kiyohiko
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252161657.78
249 rdf:type schema:Person
250 sg:person.01277263470.36 schema:affiliation https://www.grid.ac/institutes/grid.410813.f
251 schema:familyName Izutsu
252 schema:givenName Koji
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277263470.36
254 rdf:type schema:Person
255 sg:person.01313325643.14 schema:affiliation https://www.grid.ac/institutes/grid.417755.5
256 schema:familyName Murayama
257 schema:givenName Tohru
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313325643.14
259 rdf:type schema:Person
260 sg:person.01320436003.92 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
261 schema:familyName Taniwaki
262 schema:givenName Masafumi
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320436003.92
264 rdf:type schema:Person
265 sg:person.01321520521.34 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
266 schema:familyName Ohmachi
267 schema:givenName Ken
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321520521.34
269 rdf:type schema:Person
270 sg:person.01332044324.88 schema:affiliation https://www.grid.ac/institutes/grid.413410.3
271 schema:familyName Uchida
272 schema:givenName Toshiki
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332044324.88
274 rdf:type schema:Person
275 sg:person.01351454103.34 schema:affiliation https://www.grid.ac/institutes/grid.415740.3
276 schema:familyName Yoshida
277 schema:givenName Isao
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351454103.34
279 rdf:type schema:Person
280 sg:person.01356462526.00 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
281 schema:familyName Tsukasaki
282 schema:givenName Kunihiro
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356462526.00
284 rdf:type schema:Person
285 sg:person.01364745540.48 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
286 schema:familyName Tsukamoto
287 schema:givenName Norifumi
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364745540.48
289 rdf:type schema:Person
290 sg:person.014166016450.56 schema:affiliation https://www.grid.ac/institutes/grid.418587.7
291 schema:familyName Ueda
292 schema:givenName Eisuke
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014166016450.56
294 rdf:type schema:Person
295 sg:person.0601706771.30 schema:affiliation https://www.grid.ac/institutes/grid.263518.b
296 schema:familyName Ishida
297 schema:givenName Fumihiro
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601706771.30
299 rdf:type schema:Person
300 sg:person.0651040257.65 schema:affiliation https://www.grid.ac/institutes/grid.470097.d
301 schema:familyName Mihara
302 schema:givenName Keichiro
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651040257.65
304 rdf:type schema:Person
305 sg:person.0676267123.41 schema:affiliation https://www.grid.ac/institutes/grid.274841.c
306 schema:familyName Kikukawa
307 schema:givenName Yoshitaka
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676267123.41
309 rdf:type schema:Person
310 sg:person.0745256126.40 schema:affiliation https://www.grid.ac/institutes/grid.470350.5
311 schema:familyName Choi
312 schema:givenName Ilseung
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745256126.40
314 rdf:type schema:Person
315 sg:person.07565420012.12 schema:affiliation https://www.grid.ac/institutes/grid.413825.9
316 schema:familyName Kubo
317 schema:givenName Kohmei
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07565420012.12
319 rdf:type schema:Person
320 sg:pub.10.1007/bf02982692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046125242
321 https://doi.org/10.1007/bf02982692
322 rdf:type schema:CreativeWork
323 sg:pub.10.1007/s00520-017-3747-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1085615092
324 https://doi.org/10.1007/s00520-017-3747-z
325 rdf:type schema:CreativeWork
326 sg:pub.10.1007/s12185-016-2097-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013414658
327 https://doi.org/10.1007/s12185-016-2097-9
328 rdf:type schema:CreativeWork
329 sg:pub.10.1007/s12325-016-0451-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043698358
330 https://doi.org/10.1007/s12325-016-0451-1
331 rdf:type schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1083095803 schema:CreativeWork
333 https://doi.org/10.1002/hon.2437_20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085906729
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s1470-2045(16)30097-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028366269
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s2352-3026(14)70008-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018494472
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1056/nejmoa1313984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014014595
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1056/nejmoa1614598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092089645
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1102/1470-7330.2005.0038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015440550
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/bjh.12659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026338058
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1158/1535-7163.mct-12-1182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019564994
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1182/blood-2003-12-4434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027887474
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1182/blood-2004-08-3175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033024465
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1182/blood-2005-01-0016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019752393
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1182/blood-2008-04-153189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029707044
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1182/blood-2009-06-225979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039920012
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1182/blood-2013-01-481341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026442210
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1182/blood-2016-06-718544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028625516
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1200/jco.1997.15.3.1110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083057227
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1200/jco.2006.06.4618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034611434
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1200/jco.2006.09.2403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045509899
368 rdf:type schema:CreativeWork
369 https://doi.org/10.3960/jslrt.54.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004420388
370 rdf:type schema:CreativeWork
371 https://www.grid.ac/institutes/grid.256642.1 schema:alternateName Gunma University
372 schema:name Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.260433.0 schema:alternateName Nagoya City University
375 schema:name Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.263518.b schema:alternateName Shinshu University
378 schema:name Shinshu University School of Medicine, Nagano, Japan
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.265061.6 schema:alternateName Tokai University
381 schema:name School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, Japan
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.272242.3 schema:alternateName National Cancer Centre
384 schema:name National Cancer Center Hospital East, Chiba, Japan
385 National Cancer Center Hospital, Tokyo, Japan
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.272458.e schema:alternateName Kyoto Prefectural University of Medicine
388 schema:name Kyoto Prefectural University of Medicine, Kyoto, Japan
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.274841.c schema:alternateName Kumamoto University
391 schema:name Kumamoto University Graduate School of Medicine, Kumamoto, Japan
392 rdf:type schema:Organization
393 https://www.grid.ac/institutes/grid.410800.d schema:alternateName Aichi Cancer Center
394 schema:name Aichi Cancer Center, Nagoya, Aichi, Japan
395 rdf:type schema:Organization
396 https://www.grid.ac/institutes/grid.410804.9 schema:alternateName Jichi Medical University
397 schema:name Jichi Medical University, Shimotsuke, Tochigi, Japan
398 rdf:type schema:Organization
399 https://www.grid.ac/institutes/grid.410813.f schema:alternateName Toranomon Hospital
400 schema:name Toranomon Hospital, Tokyo, Japan
401 rdf:type schema:Organization
402 https://www.grid.ac/institutes/grid.410843.a schema:alternateName Kobe City Medical Center General Hospital
403 schema:name Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan
404 rdf:type schema:Organization
405 https://www.grid.ac/institutes/grid.411898.d schema:alternateName Jikei University
406 schema:name The Jikei University School of Medicine, Tokyo, Japan
407 rdf:type schema:Organization
408 https://www.grid.ac/institutes/grid.413410.3 schema:alternateName Japanese Red Cross Nagoya Daini Hospital
409 schema:name Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan
410 rdf:type schema:Organization
411 https://www.grid.ac/institutes/grid.413825.9 schema:alternateName Aomori Prefectural Central Hospital
412 schema:name Aomori Prefectural Central Hospital, Aomori, Japan
413 rdf:type schema:Organization
414 https://www.grid.ac/institutes/grid.415740.3 schema:alternateName Shikoku Cancer Center
415 schema:name National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.416203.2 schema:alternateName Niigata Cancer Center Hospital
418 schema:name Niigata Cancer Center Hospital, Niigata, Japan
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.416591.e schema:alternateName Matsushita Memorial Hospital
421 schema:name Matsushita Memorial Hospital, Moriguchi, Osaka, Japan
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.417755.5 schema:alternateName Hyogo Prefectural Cancer Center
424 schema:name Hyogo Cancer Center, Akashi, Hyogo, Japan
425 rdf:type schema:Organization
426 https://www.grid.ac/institutes/grid.418490.0 schema:alternateName Chiba Cancer Center
427 schema:name Chiba Cancer Center, Chiba, Japan
428 rdf:type schema:Organization
429 https://www.grid.ac/institutes/grid.418587.7 schema:alternateName Roche (Japan)
430 schema:name Chugai Pharmaceutical Co., Ltd., Tokyo, Japan
431 rdf:type schema:Organization
432 https://www.grid.ac/institutes/grid.470097.d schema:alternateName Hiroshima University Hospital
433 schema:name Hiroshima University Hospital, Hiroshima, Japan
434 rdf:type schema:Organization
435 https://www.grid.ac/institutes/grid.470350.5 schema:alternateName National Hospital Organization Kyushu Cancer Center
436 schema:name National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
437 rdf:type schema:Organization
438 https://www.grid.ac/institutes/grid.486756.e schema:alternateName The Cancer Institute Hospital
439 schema:name The Cancer Institute Hospital, Tokyo, Japan
440 rdf:type schema:Organization
441 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
442 schema:name Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
443 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...