Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07-03

AUTHORS

Takashi Taga, Toshihiko Imamura, Kentaro Nakashima, Naoko Maeda, Akihiro Watanabe, Yuji Miyajima, Sachi Sakaguchi, Hitoshi Sano, Daiichiro Hasegawa, Hirohide Kawasaki, Souichi Adachi, Masatoshi Takagi, Katsuyoshi Koh, Atsushi Manabe, Tomohiko Taki, Yasushi Ishida

ABSTRACT

Myeloid sarcoma (MS) is a rare neoplastic condition that is often described in association with acute myeloid leukemia (AML). MS in childhood has received little attention, particularly in Japan. We carried out a nationwide retrospective analysis of Japanese children diagnosed with MS without bone marrow involvement. Inclusion criteria were diagnosis of MS at younger than 20 years of age between January 1, 2000 and December 31, 2013. There was a predominance of males (8:2), and the median age at MS diagnosis was 4 years. Sites of involvement varied and included skin (n = 3), head and/or neck (n = 2), and multiple sites (n = 2). Karyotypes were evaluated in seven patients, with one individual carrying t(8;21) and t(9;11). Four patients developed bone marrow involvement 2–55 months after diagnosis of MS. All patients received chemotherapy for de novo AML and two individuals received HSCT in first remission. Seven of ten patients survived for 50–152 months (median, 93 months) without disease after initial chemotherapy. This retrospective study confirmed that pediatric MS without bone marrow involvement in Japan is a very rare disease. MS patients responded favorably to therapies for de novo AML, and HSCT in first remission was not indicated for all patients. More... »

PAGES

438-442

Journal

TITLE

International Journal of Hematology

ISSUE

4

VOLUME

108

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-018-2492-5

DOI

http://dx.doi.org/10.1007/s12185-018-2492-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105294232

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29971602


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23 schema:description Myeloid sarcoma (MS) is a rare neoplastic condition that is often described in association with acute myeloid leukemia (AML). MS in childhood has received little attention, particularly in Japan. We carried out a nationwide retrospective analysis of Japanese children diagnosed with MS without bone marrow involvement. Inclusion criteria were diagnosis of MS at younger than 20 years of age between January 1, 2000 and December 31, 2013. There was a predominance of males (8:2), and the median age at MS diagnosis was 4 years. Sites of involvement varied and included skin (n = 3), head and/or neck (n = 2), and multiple sites (n = 2). Karyotypes were evaluated in seven patients, with one individual carrying t(8;21) and t(9;11). Four patients developed bone marrow involvement 2–55 months after diagnosis of MS. All patients received chemotherapy for de novo AML and two individuals received HSCT in first remission. Seven of ten patients survived for 50–152 months (median, 93 months) without disease after initial chemotherapy. This retrospective study confirmed that pediatric MS without bone marrow involvement in Japan is a very rare disease. MS patients responded favorably to therapies for de novo AML, and HSCT in first remission was not indicated for all patients.
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30 schema:keywords HSCT
31 Japan
32 Japanese children
33 MS diagnosis
34 MS patients
35 acute myeloid leukemia
36 age
37 analysis
38 association
39 attention
40 bone marrow involvement
41 bone marrow involvement 2
42 carrying
43 characteristics
44 chemotherapy
45 childhood
46 children
47 clinical characteristics
48 conditions
49 criteria
50 de novo acute myeloid leukemia
51 diagnosis
52 diagnosis of MS
53 disease
54 first remission
55 head
56 inclusion criteria
57 individual carrying
58 individuals
59 initial chemotherapy
60 involvement
61 involvement 2
62 karyotype
63 leukemia
64 little attention
65 males
66 marrow involvement
67 median age
68 months
69 multiple sites
70 myeloid leukemia
71 myeloid sarcoma
72 nationwide retrospective analysis
73 neck
74 neoplastic conditions
75 novo acute myeloid leukemia
76 patients
77 pediatric MS
78 pediatric patients
79 predominance
80 predominance of males
81 rare disease
82 rare neoplastic condition
83 remission
84 retrospective analysis
85 retrospective study
86 sarcoma
87 site of involvement
88 sites
89 skin
90 study
91 therapy
92 years
93 years of age
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