Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi, Takeshi Inukai, Kanji Sugita, Hajime Hosoi

ABSTRACT

In this study, we performed genetic analysis of 83 B cell precursor acute lymphoblastic leukemia (B-ALL) cell lines. First, we performed multiplex ligation-dependent probe amplification analysis to identify copy number abnormalities (CNAs) in eight genes associated with B-ALL according to genetic subtype. In Ph+ B-ALL cell lines, the frequencies of IKZF1, CDKN2A/2B, BTG1, and PAX5 deletion were significantly higher than those in Ph- B-ALL cell lines. The frequency of CDKN2A/2B deletion in KMT2A rearranged cell lines was significantly lower than that in non-KMT2A rearranged cell lines. These findings suggest that CNAs are correlated with genetic subtype in B-ALL cell lines. In addition, we determined that three B-other ALL cell lines had IKZF1 deletions (YCUB-5, KOPN49, and KOPN75); we therefore performed comprehensive genetic analysis of these cell lines. YCUB-5, KOPN49, and KOPN75 had P2RY8-CRLF2, IgH-CRLF2, and PAX5-ETV6 fusions, respectively. Moreover, targeted capture sequencing revealed that YCUB-5 had JAK2 R683I and KRAS G12D, and KOPN49 had JAK2 R683G and KRAS G13D mutations. These data may contribute to progress in the field of leukemia research. More... »

PAGES

312-318

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-018-2474-7

DOI

http://dx.doi.org/10.1007/s12185-018-2474-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104131826

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29786757


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p15", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Copy Number Variations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone-Lysine N-Methyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ikaros Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Janus Kinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid-Lymphoid Leukemia Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PAX5 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor B-Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kyoto Prefectural University of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan", 
            "Department of Pediatrics, National Hospital Organization Maizuru Medical Center, Maizuru, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomoyasu", 
        "givenName": "Chihiro", 
        "id": "sg:person.01322077625.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322077625.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto Prefectural University of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imamura", 
        "givenName": "Toshihiko", 
        "id": "sg:person.01261210177.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261210177.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto Prefectural University of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomii", 
        "givenName": "Toshihiro", 
        "id": "sg:person.013707527711.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013707527711.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415597.b", 
          "name": [
            "Department of Pediatrics, Kyoto City Hospital, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yano", 
        "givenName": "Mio", 
        "id": "sg:person.0730664224.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730664224.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asai", 
        "givenName": "Daisuke", 
        "id": "sg:person.01145635663.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145635663.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kanagawa Children's Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.414947.b", 
          "name": [
            "Division of Hemato-Oncology and Regenerative Medicine, Kanagawa Children\u2019s Medical Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goto", 
        "givenName": "Hiroaki", 
        "id": "sg:person.0607442360.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607442360.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Okayama University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412342.2", 
          "name": [
            "Department of Pediatric Hematology/Oncology, Okayama University Hospital, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimada", 
        "givenName": "Akira", 
        "id": "sg:person.0762230024.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762230024.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410840.9", 
          "name": [
            "Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanada", 
        "givenName": "Masashi", 
        "id": "sg:person.0620134357.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620134357.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mie University", 
          "id": "https://www.grid.ac/institutes/grid.260026.0", 
          "name": [
            "Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwamoto", 
        "givenName": "Shotaro", 
        "id": "sg:person.0576155001.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576155001.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takita", 
        "givenName": "Junko", 
        "id": "sg:person.0747556301.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747556301.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japanese Red Cross Society, Japan", 
          "id": "https://www.grid.ac/institutes/grid.410775.0", 
          "name": [
            "Japanese Red Cross Fukushima Blood Center, Okuma, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minegishi", 
        "givenName": "Masayoshi", 
        "id": "sg:person.0752226763.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752226763.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pediatrics, Yamanashi University, Kofu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inukai", 
        "givenName": "Takeshi", 
        "id": "sg:person.0603233700.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603233700.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pediatrics, Yamanashi University, Kofu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugita", 
        "givenName": "Kanji", 
        "id": "sg:person.011244261442.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011244261442.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto Prefectural University of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hosoi", 
        "givenName": "Hajime", 
        "id": "sg:person.0676125511.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676125511.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood-2011-11-394221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006535624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2013.085175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007068998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-08-2911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008488186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.leukres.2008.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009363925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010592842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2010.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011613515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1620/tjem.151.283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012863955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-01-199307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013677501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2015.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014955687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1403088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023950369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.leukres.2008.07.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025941514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030307062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.26100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031918622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2013.308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034362125", 
          "https://doi.org/10.1038/leu.2013.308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2013.308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034362125", 
          "https://doi.org/10.1038/leu.2013.308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(08)70339-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041314041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bcj.2016.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042280093", 
          "https://doi.org/10.1038/bcj.2016.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10428194.2016.1228925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042615851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2003.04699.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044668825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-09-244673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046935969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047129695", 
          "https://doi.org/10.1038/sj.leu.2403769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047129695", 
          "https://doi.org/10.1038/sj.leu.2403769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047474651", 
          "https://doi.org/10.1038/sj.leu.2403670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047474651", 
          "https://doi.org/10.1038/sj.leu.2403670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2012.281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047612524", 
          "https://doi.org/10.1038/leu.2012.281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047667800", 
          "https://doi.org/10.1038/sj.leu.2402923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047667800", 
          "https://doi.org/10.1038/sj.leu.2402923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cam4.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052587007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-03-415448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053194132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2016.153023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071145320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074834916", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05213.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075971597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082082885", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082482178", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083307814", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2016-12-758979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084826329"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-09", 
    "datePublishedReg": "2018-09-01", 
    "description": "In this study, we performed genetic analysis of 83 B cell precursor acute lymphoblastic leukemia (B-ALL) cell lines. First, we performed multiplex ligation-dependent probe amplification analysis to identify copy number abnormalities (CNAs) in eight genes associated with B-ALL according to genetic subtype. In Ph+ B-ALL cell lines, the frequencies of IKZF1, CDKN2A/2B, BTG1, and PAX5 deletion were significantly higher than those in Ph- B-ALL cell lines. The frequency of CDKN2A/2B deletion in KMT2A rearranged cell lines was significantly lower than that in non-KMT2A rearranged cell lines. These findings suggest that CNAs are correlated with genetic subtype in B-ALL cell lines. In addition, we determined that three B-other ALL cell lines had IKZF1 deletions (YCUB-5, KOPN49, and KOPN75); we therefore performed comprehensive genetic analysis of these cell lines. YCUB-5, KOPN49, and KOPN75 had P2RY8-CRLF2, IgH-CRLF2, and PAX5-ETV6 fusions, respectively. Moreover, targeted capture sequencing revealed that YCUB-5 had JAK2 R683I and KRAS G12D, and KOPN49 had JAK2 R683G and KRAS G13D mutations. These data may contribute to progress in the field of leukemia research.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12185-018-2474-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1076985", 
        "issn": [
          "0925-5710", 
          "1865-3774"
        ], 
        "name": "International Journal of Hematology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "108"
      }
    ], 
    "name": "Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes", 
    "pagination": "312-318", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1be6830bb2f1386ea13e1b16409a09bd928ca15a36cdb5d3978897c54caeb544"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29786757"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9111627"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12185-018-2474-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104131826"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12185-018-2474-7", 
      "https://app.dimensions.ai/details/publication/pub.1104131826"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000578.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12185-018-2474-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2474-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2474-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2474-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2474-7'


 

This table displays all metadata directly associated to this object as RDF triples.

353 TRIPLES      21 PREDICATES      78 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12185-018-2474-7 schema:about N286f3a74cb1d41f5b5be35cf52da462e
2 N2c0efd80c83c47e99abf2224e4531ede
3 N301b5bbf5a324033bd0d0d1c61e6bfa1
4 N3983ce1abd7645efb33f041f21acd5a3
5 N3cd5bc2ef8624ba0b568e7d6c79476bb
6 N4440f239212c413e9cfbe7d73221217e
7 N4a4027b8ad964dac96ea03ca0af12c41
8 N6c0170524d6746d6babccf2a07cb30af
9 N72a040541f9449aca4cac3b8f1cdc80e
10 N7a2c08f13bfd43c8805159f8d3f86718
11 N9ff9027235b843e9923c63932d6e2e01
12 Na622dafeddd14a3485ad7046e0de3b2c
13 Na7a745f0ba454c829f7bcb7a808e5740
14 Nbfc2c3dcbdf04227878e9d32bb578670
15 Nc07d376c489f47cd92818b06e4244237
16 Nd77bc1a4c0064b8ca8d5b4d6ef66cb6f
17 Ndc4c9f29a3f34760ad33b7a647510360
18 anzsrc-for:06
19 anzsrc-for:0604
20 schema:author Ndf6253114ac34846a5b8a5e9701ed988
21 schema:citation sg:pub.10.1038/bcj.2016.28
22 sg:pub.10.1038/leu.2012.281
23 sg:pub.10.1038/leu.2013.308
24 sg:pub.10.1038/sj.leu.2402923
25 sg:pub.10.1038/sj.leu.2403670
26 sg:pub.10.1038/sj.leu.2403769
27 https://app.dimensions.ai/details/publication/pub.1074834916
28 https://app.dimensions.ai/details/publication/pub.1082082885
29 https://app.dimensions.ai/details/publication/pub.1082482178
30 https://app.dimensions.ai/details/publication/pub.1083307814
31 https://doi.org/10.1002/cam4.87
32 https://doi.org/10.1002/j.1460-2075.1992.tb05213.x
33 https://doi.org/10.1002/pbc.26100
34 https://doi.org/10.1016/j.ccell.2015.07.016
35 https://doi.org/10.1016/j.ccr.2012.06.005
36 https://doi.org/10.1016/j.cell.2006.10.003
37 https://doi.org/10.1016/j.exphem.2010.04.017
38 https://doi.org/10.1016/j.leukres.2008.07.023
39 https://doi.org/10.1016/j.leukres.2008.12.003
40 https://doi.org/10.1016/s1470-2045(08)70339-5
41 https://doi.org/10.1046/j.1365-2141.2003.04699.x
42 https://doi.org/10.1056/nejmoa1403088
43 https://doi.org/10.1080/10428194.2016.1228925
44 https://doi.org/10.1182/blood-2003-08-2911
45 https://doi.org/10.1182/blood-2009-01-199307
46 https://doi.org/10.1182/blood-2009-09-244673
47 https://doi.org/10.1182/blood-2011-11-394221
48 https://doi.org/10.1182/blood-2012-03-415448
49 https://doi.org/10.1182/blood-2016-12-758979
50 https://doi.org/10.1620/tjem.151.283
51 https://doi.org/10.3324/haematol.2013.085175
52 https://doi.org/10.3324/haematol.2016.153023
53 schema:datePublished 2018-09
54 schema:datePublishedReg 2018-09-01
55 schema:description In this study, we performed genetic analysis of 83 B cell precursor acute lymphoblastic leukemia (B-ALL) cell lines. First, we performed multiplex ligation-dependent probe amplification analysis to identify copy number abnormalities (CNAs) in eight genes associated with B-ALL according to genetic subtype. In Ph<sup>+</sup> B-ALL cell lines, the frequencies of IKZF1, CDKN2A/2B, BTG1, and PAX5 deletion were significantly higher than those in Ph<sup>-</sup> B-ALL cell lines. The frequency of CDKN2A/2B deletion in KMT2A rearranged cell lines was significantly lower than that in non-KMT2A rearranged cell lines. These findings suggest that CNAs are correlated with genetic subtype in B-ALL cell lines. In addition, we determined that three B-other ALL cell lines had IKZF1 deletions (YCUB-5, KOPN49, and KOPN75); we therefore performed comprehensive genetic analysis of these cell lines. YCUB-5, KOPN49, and KOPN75 had P2RY8-CRLF2, IgH-CRLF2, and PAX5-ETV6 fusions, respectively. Moreover, targeted capture sequencing revealed that YCUB-5 had JAK2 R683I and KRAS G12D, and KOPN49 had JAK2 R683G and KRAS G13D mutations. These data may contribute to progress in the field of leukemia research.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree false
59 schema:isPartOf N315b1d3f9477414c87c7ce8ddd773942
60 Ndaa19e3118694ad2bc341a00d0d043a7
61 sg:journal.1076985
62 schema:name Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes
63 schema:pagination 312-318
64 schema:productId N09c3badfc0c146058c9b757bc50f9a09
65 N4f51526333fb4a188dccc9d7624893d8
66 N8f260caef95e4daf8b023cff4592605f
67 N9c944d38872f417092d612e86fc20065
68 Nc08fef3e779b4af6b9b2ef23d8a5b19e
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104131826
70 https://doi.org/10.1007/s12185-018-2474-7
71 schema:sdDatePublished 2019-04-10T17:41
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher Nf29212c29f4c48ab83d7b7ffa044ad55
74 schema:url https://link.springer.com/10.1007%2Fs12185-018-2474-7
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N028d8f7e83104c28b358e8214b57e533 rdf:first sg:person.0752226763.01
79 rdf:rest Nc6a56722f7f54b4f92dc86f3a9454441
80 N09c3badfc0c146058c9b757bc50f9a09 schema:name dimensions_id
81 schema:value pub.1104131826
82 rdf:type schema:PropertyValue
83 N1735a180fb1840759b1a261b12e9ad73 rdf:first sg:person.01145635663.58
84 rdf:rest N9254b4dcfeeb4689920798d3a0f2099c
85 N208dbf6245c84b5083f1f438cd522464 rdf:first sg:person.0576155001.51
86 rdf:rest N2c39b47362ab4da998325abfbcf94616
87 N286f3a74cb1d41f5b5be35cf52da462e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Myeloid-Lymphoid Leukemia Protein
89 rdf:type schema:DefinedTerm
90 N2c0efd80c83c47e99abf2224e4531ede schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Proto-Oncogene Proteins p21(ras)
92 rdf:type schema:DefinedTerm
93 N2c39b47362ab4da998325abfbcf94616 rdf:first sg:person.0747556301.06
94 rdf:rest N028d8f7e83104c28b358e8214b57e533
95 N2f3a03b1254441d4ba5aa31b987f6916 rdf:first sg:person.013707527711.11
96 rdf:rest Nfc17494205e645d68c91ae74b3d06a5a
97 N301b5bbf5a324033bd0d0d1c61e6bfa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Cyclin-Dependent Kinase Inhibitor p18
99 rdf:type schema:DefinedTerm
100 N315b1d3f9477414c87c7ce8ddd773942 schema:issueNumber 3
101 rdf:type schema:PublicationIssue
102 N3983ce1abd7645efb33f041f21acd5a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name DNA Copy Number Variations
104 rdf:type schema:DefinedTerm
105 N3a8c4189dd2f43d8bb4f3e35bc68b332 rdf:first sg:person.0620134357.25
106 rdf:rest N208dbf6245c84b5083f1f438cd522464
107 N3cd5bc2ef8624ba0b568e7d6c79476bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Ikaros Transcription Factor
109 rdf:type schema:DefinedTerm
110 N4440f239212c413e9cfbe7d73221217e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
112 rdf:type schema:DefinedTerm
113 N4a4027b8ad964dac96ea03ca0af12c41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Gene Rearrangement
115 rdf:type schema:DefinedTerm
116 N4f51526333fb4a188dccc9d7624893d8 schema:name readcube_id
117 schema:value 1be6830bb2f1386ea13e1b16409a09bd928ca15a36cdb5d3978897c54caeb544
118 rdf:type schema:PropertyValue
119 N6c0170524d6746d6babccf2a07cb30af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Janus Kinase 2
121 rdf:type schema:DefinedTerm
122 N72a040541f9449aca4cac3b8f1cdc80e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Neoplasm Proteins
124 rdf:type schema:DefinedTerm
125 N7a2c08f13bfd43c8805159f8d3f86718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mutation
127 rdf:type schema:DefinedTerm
128 N854def751f324d02b6817cf1ff984cda rdf:first sg:person.01261210177.04
129 rdf:rest N2f3a03b1254441d4ba5aa31b987f6916
130 N8f260caef95e4daf8b023cff4592605f schema:name pubmed_id
131 schema:value 29786757
132 rdf:type schema:PropertyValue
133 N9254b4dcfeeb4689920798d3a0f2099c rdf:first sg:person.0607442360.54
134 rdf:rest Nb0a3594ed337417885e5b8a0b0d4db06
135 N925d0bc7a15a436db9e575d682df7372 rdf:first sg:person.0676125511.32
136 rdf:rest rdf:nil
137 N9c944d38872f417092d612e86fc20065 schema:name doi
138 schema:value 10.1007/s12185-018-2474-7
139 rdf:type schema:PropertyValue
140 N9ff9027235b843e9923c63932d6e2e01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Humans
142 rdf:type schema:DefinedTerm
143 Na622dafeddd14a3485ad7046e0de3b2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name PAX5 Transcription Factor
145 rdf:type schema:DefinedTerm
146 Na7a745f0ba454c829f7bcb7a808e5740 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Gene Dosage
148 rdf:type schema:DefinedTerm
149 Nb0a3594ed337417885e5b8a0b0d4db06 rdf:first sg:person.0762230024.01
150 rdf:rest N3a8c4189dd2f43d8bb4f3e35bc68b332
151 Nb67708443bd24a9ab46cc7094ad2efac schema:name Department of Pediatrics, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan
152 rdf:type schema:Organization
153 Nbfc2c3dcbdf04227878e9d32bb578670 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cyclin-Dependent Kinase Inhibitor p15
155 rdf:type schema:DefinedTerm
156 Nc07d376c489f47cd92818b06e4244237 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Cell Line, Tumor
158 rdf:type schema:DefinedTerm
159 Nc08fef3e779b4af6b9b2ef23d8a5b19e schema:name nlm_unique_id
160 schema:value 9111627
161 rdf:type schema:PropertyValue
162 Nc6a56722f7f54b4f92dc86f3a9454441 rdf:first sg:person.0603233700.55
163 rdf:rest Ne3e8683fd0414a8db3774c16095189c8
164 Nd77bc1a4c0064b8ca8d5b4d6ef66cb6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Gene Deletion
166 rdf:type schema:DefinedTerm
167 Ndaa19e3118694ad2bc341a00d0d043a7 schema:volumeNumber 108
168 rdf:type schema:PublicationVolume
169 Ndc4c9f29a3f34760ad33b7a647510360 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Histone-Lysine N-Methyltransferase
171 rdf:type schema:DefinedTerm
172 Ndf6253114ac34846a5b8a5e9701ed988 rdf:first sg:person.01322077625.21
173 rdf:rest N854def751f324d02b6817cf1ff984cda
174 Ne3e8683fd0414a8db3774c16095189c8 rdf:first sg:person.011244261442.67
175 rdf:rest N925d0bc7a15a436db9e575d682df7372
176 Nf29212c29f4c48ab83d7b7ffa044ad55 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 Nfc17494205e645d68c91ae74b3d06a5a rdf:first sg:person.0730664224.51
179 rdf:rest N1735a180fb1840759b1a261b12e9ad73
180 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
181 schema:name Biological Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
184 schema:name Genetics
185 rdf:type schema:DefinedTerm
186 sg:journal.1076985 schema:issn 0925-5710
187 1865-3774
188 schema:name International Journal of Hematology
189 rdf:type schema:Periodical
190 sg:person.011244261442.67 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
191 schema:familyName Sugita
192 schema:givenName Kanji
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011244261442.67
194 rdf:type schema:Person
195 sg:person.01145635663.58 schema:affiliation Nb67708443bd24a9ab46cc7094ad2efac
196 schema:familyName Asai
197 schema:givenName Daisuke
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145635663.58
199 rdf:type schema:Person
200 sg:person.01261210177.04 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
201 schema:familyName Imamura
202 schema:givenName Toshihiko
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261210177.04
204 rdf:type schema:Person
205 sg:person.01322077625.21 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
206 schema:familyName Tomoyasu
207 schema:givenName Chihiro
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322077625.21
209 rdf:type schema:Person
210 sg:person.013707527711.11 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
211 schema:familyName Tomii
212 schema:givenName Toshihiro
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013707527711.11
214 rdf:type schema:Person
215 sg:person.0576155001.51 schema:affiliation https://www.grid.ac/institutes/grid.260026.0
216 schema:familyName Iwamoto
217 schema:givenName Shotaro
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576155001.51
219 rdf:type schema:Person
220 sg:person.0603233700.55 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
221 schema:familyName Inukai
222 schema:givenName Takeshi
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603233700.55
224 rdf:type schema:Person
225 sg:person.0607442360.54 schema:affiliation https://www.grid.ac/institutes/grid.414947.b
226 schema:familyName Goto
227 schema:givenName Hiroaki
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607442360.54
229 rdf:type schema:Person
230 sg:person.0620134357.25 schema:affiliation https://www.grid.ac/institutes/grid.410840.9
231 schema:familyName Sanada
232 schema:givenName Masashi
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620134357.25
234 rdf:type schema:Person
235 sg:person.0676125511.32 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
236 schema:familyName Hosoi
237 schema:givenName Hajime
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676125511.32
239 rdf:type schema:Person
240 sg:person.0730664224.51 schema:affiliation https://www.grid.ac/institutes/grid.415597.b
241 schema:familyName Yano
242 schema:givenName Mio
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730664224.51
244 rdf:type schema:Person
245 sg:person.0747556301.06 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
246 schema:familyName Takita
247 schema:givenName Junko
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747556301.06
249 rdf:type schema:Person
250 sg:person.0752226763.01 schema:affiliation https://www.grid.ac/institutes/grid.410775.0
251 schema:familyName Minegishi
252 schema:givenName Masayoshi
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752226763.01
254 rdf:type schema:Person
255 sg:person.0762230024.01 schema:affiliation https://www.grid.ac/institutes/grid.412342.2
256 schema:familyName Shimada
257 schema:givenName Akira
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762230024.01
259 rdf:type schema:Person
260 sg:pub.10.1038/bcj.2016.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042280093
261 https://doi.org/10.1038/bcj.2016.28
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/leu.2012.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047612524
264 https://doi.org/10.1038/leu.2012.281
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/leu.2013.308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034362125
267 https://doi.org/10.1038/leu.2013.308
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/sj.leu.2402923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047667800
270 https://doi.org/10.1038/sj.leu.2402923
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/sj.leu.2403670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047474651
273 https://doi.org/10.1038/sj.leu.2403670
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/sj.leu.2403769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047129695
276 https://doi.org/10.1038/sj.leu.2403769
277 rdf:type schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1074834916 schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1082082885 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1082482178 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1083307814 schema:CreativeWork
282 https://doi.org/10.1002/cam4.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052587007
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/j.1460-2075.1992.tb05213.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075971597
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/pbc.26100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031918622
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.ccell.2015.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014955687
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.ccr.2012.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010592842
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.cell.2006.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030307062
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.exphem.2010.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011613515
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.leukres.2008.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025941514
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.leukres.2008.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009363925
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s1470-2045(08)70339-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041314041
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1046/j.1365-2141.2003.04699.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044668825
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1056/nejmoa1403088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023950369
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1080/10428194.2016.1228925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042615851
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1182/blood-2003-08-2911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008488186
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1182/blood-2009-01-199307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013677501
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1182/blood-2009-09-244673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046935969
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1182/blood-2011-11-394221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006535624
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1182/blood-2012-03-415448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053194132
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1182/blood-2016-12-758979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084826329
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1620/tjem.151.283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012863955
321 rdf:type schema:CreativeWork
322 https://doi.org/10.3324/haematol.2013.085175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007068998
323 rdf:type schema:CreativeWork
324 https://doi.org/10.3324/haematol.2016.153023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071145320
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.260026.0 schema:alternateName Mie University
327 schema:name Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.267500.6 schema:alternateName University of Yamanashi
330 schema:name Department of Pediatrics, Yamanashi University, Kofu, Japan
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
333 schema:name Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.272458.e schema:alternateName Kyoto Prefectural University of Medicine
336 schema:name Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan
337 Department of Pediatrics, National Hospital Organization Maizuru Medical Center, Maizuru, Japan
338 rdf:type schema:Organization
339 https://www.grid.ac/institutes/grid.410775.0 schema:alternateName Japanese Red Cross Society, Japan
340 schema:name Japanese Red Cross Fukushima Blood Center, Okuma, Japan
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.410840.9 schema:alternateName Nagoya Medical Center
343 schema:name Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.412342.2 schema:alternateName Okayama University Hospital
346 schema:name Department of Pediatric Hematology/Oncology, Okayama University Hospital, Okayama, Japan
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.414947.b schema:alternateName Kanagawa Children's Medical Center
349 schema:name Division of Hemato-Oncology and Regenerative Medicine, Kanagawa Children’s Medical Center, Yokohama, Japan
350 rdf:type schema:Organization
351 https://www.grid.ac/institutes/grid.415597.b schema:alternateName Kyoto City Hospital
352 schema:name Department of Pediatrics, Kyoto City Hospital, Kyoto, Japan
353 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...