Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03-26

AUTHORS

Taisuke Narazaki, Shojiro Haji, Yasuhiro Nakashima, Yasuhiro Tsukamoto, Mariko Tsuda, Akiko Takamatsu, Hirofumi Ohno, Takamitsu Matsushima, Tomoko Matsumoto, Keiji Nogami, Midori Shima, Motoaki Shiratsuchi, Yoshihiro Ogawa

ABSTRACT

A case of acquired hemophilia A (AHA) that developed in a patient with autoimmune pancreatitis (AIP) is presented. A 64-year-old woman was diagnosed with AIP in 2007. The symptoms resolved with prednisolone (PSL). Although the dose of PSL was tapered to 7.5 mg/day for maintenance, serum IgG4 levels remained high. She suddenly presented with subcutaneous bleeding in 2015. Her activated partial thromboplastin time was prolonged (80.0 s). A mixing test showed an inhibitor pattern, factor VIII (FVIII) activity was less than 1%, and FVIII inhibitor was 290 BU/mL. She was diagnosed with AHA. Her serum IgG4 was elevated to 133 mg/dL. She was treated first with PSL alone, but she developed bladder tamponade. Cyclophosphamide and activated prothrombin complex concentrate were combined with PSL. She then achieved hemostasis, and FVIII inhibitor disappeared. FVIII inhibitor had been detected since PSL was tapered and AHA recurred two months later. An enzyme-linked immunosorbent assay showed that the inhibitor was mainly IgG4 and IgG1. This case suggests that elevation of IgG4 may be associated with the development of both AHA and AIP. More... »

PAGES

335-338

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-018-2441-3

DOI

http://dx.doi.org/10.1007/s12185-018-2441-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101768686

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29582334


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation Factor Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Factor VIII", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemophilia A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prednisolone", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Narazaki", 
        "givenName": "Taisuke", 
        "id": "sg:person.010710762630.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010710762630.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haji", 
        "givenName": "Shojiro", 
        "id": "sg:person.0665477134.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665477134.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakashima", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.013660263332.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013660263332.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsukamoto", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.010005617251.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010005617251.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuda", 
        "givenName": "Mariko", 
        "id": "sg:person.0617363734.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617363734.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takamatsu", 
        "givenName": "Akiko", 
        "id": "sg:person.01276201766.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276201766.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohno", 
        "givenName": "Hirofumi", 
        "id": "sg:person.01131607430.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131607430.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsushima", 
        "givenName": "Takamitsu", 
        "id": "sg:person.01155405322.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155405322.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Nara Medical University, Kashihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Pediatrics, Nara Medical University, Kashihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Tomoko", 
        "id": "sg:person.0742772162.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742772162.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Nara Medical University, Kashihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Pediatrics, Nara Medical University, Kashihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nogami", 
        "givenName": "Keiji", 
        "id": "sg:person.0603447532.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603447532.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Nara Medical University, Kashihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Pediatrics, Nara Medical University, Kashihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shima", 
        "givenName": "Midori", 
        "id": "sg:person.0705772523.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705772523.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shiratsuchi", 
        "givenName": "Motoaki", 
        "id": "sg:person.01073553516.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073553516.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
            "Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogawa", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.01053527727.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053527727.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00535-006-1868-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023269678", 
          "https://doi.org/10.1007/s00535-006-1868-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-006-1862-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053147905", 
          "https://doi.org/10.1007/s00535-006-1862-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1752-1947-6-63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003885192", 
          "https://doi.org/10.1186/1752-1947-6-63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-016-2108-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047393459", 
          "https://doi.org/10.1007/s12185-016-2108-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-03-26", 
    "datePublishedReg": "2018-03-26", 
    "description": "A case of acquired hemophilia A (AHA) that developed in a patient with autoimmune pancreatitis (AIP) is presented. A 64-year-old woman was diagnosed with AIP in 2007. The symptoms resolved with prednisolone (PSL). Although the dose of PSL was tapered to 7.5\u00a0mg/day for maintenance, serum IgG4 levels remained high. She suddenly presented with subcutaneous bleeding in 2015. Her activated partial thromboplastin time was prolonged (80.0\u00a0s). A mixing test showed an inhibitor pattern, factor VIII (FVIII) activity was less than 1%, and FVIII inhibitor was 290\u00a0BU/mL. She was diagnosed with AHA. Her serum IgG4 was elevated to 133\u00a0mg/dL. She was treated first with PSL alone, but she developed bladder tamponade. Cyclophosphamide and activated prothrombin complex concentrate were combined with PSL. She then achieved hemostasis, and FVIII inhibitor disappeared. FVIII inhibitor had been detected since PSL was tapered and AHA recurred two\u00a0months later. An enzyme-linked immunosorbent assay showed that the inhibitor was mainly IgG4 and IgG1. This case suggests that elevation of IgG4 may be associated with the development of both AHA and AIP.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12185-018-2441-3", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6835617", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1076985", 
        "issn": [
          "0925-5710", 
          "1865-3774"
        ], 
        "name": "International Journal of Hematology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "108"
      }
    ], 
    "keywords": [
      "autoimmune pancreatitis", 
      "FVIII inhibitors", 
      "hemophilia A", 
      "elevation of IgG4", 
      "dose of prednisolone", 
      "serum IgG4 levels", 
      "prothrombin complex concentrate", 
      "serum IgG4 elevation", 
      "partial thromboplastin time", 
      "enzyme-linked immunosorbent", 
      "factor VIII activity", 
      "bladder tamponade", 
      "IgG4 levels", 
      "subcutaneous bleeding", 
      "serum IgG4", 
      "IgG4 elevation", 
      "complex concentrate", 
      "thromboplastin time", 
      "prednisolone", 
      "VIII activity", 
      "BU/", 
      "IgG4", 
      "pancreatitis", 
      "inhibitors", 
      "AHA", 
      "inhibitor pattern", 
      "elevation", 
      "bleeding", 
      "tamponade", 
      "cyclophosphamide", 
      "patients", 
      "symptoms", 
      "IgG1", 
      "hemostasis", 
      "immunosorbent", 
      "dose", 
      "months", 
      "women", 
      "cases", 
      "days", 
      "levels", 
      "activity", 
      "test", 
      "maintenance", 
      "concentrate", 
      "patterns", 
      "development", 
      "time"
    ], 
    "name": "Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation", 
    "pagination": "335-338", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101768686"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12185-018-2441-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29582334"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12185-018-2441-3", 
      "https://app.dimensions.ai/details/publication/pub.1101768686"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_766.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12185-018-2441-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2441-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2441-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2441-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2441-3'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      88 URIs      76 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12185-018-2441-3 schema:about N08a997930ea34baba9017309dd7baa13
2 N30e583c715914eefafbc63e595e41524
3 N41db13260ffd452c9293a368a1e3c447
4 N48581a26769e4b5d975363d4afd2d1da
5 N4c1a6ed303bd484889853fdabbae7517
6 N9cc8300f03a44bce9ef0f7fb593aa749
7 Na32b11ba254f44e384b4b2fd45588a40
8 Nad1806cbb1cb4d01a293c2b5a37654fc
9 Ncc87914c5c72496c9f01fcff725e229c
10 Nd37354c50b6e4c39852e2a2cb3d7f58f
11 Ndef15994fa054fbc8c7261b796b96b9f
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N22d4fc12f0ff4b23a0798fca03b39b4e
15 schema:citation sg:pub.10.1007/s00535-006-1862-6
16 sg:pub.10.1007/s00535-006-1868-0
17 sg:pub.10.1007/s12185-016-2108-x
18 sg:pub.10.1186/1752-1947-6-63
19 schema:datePublished 2018-03-26
20 schema:datePublishedReg 2018-03-26
21 schema:description A case of acquired hemophilia A (AHA) that developed in a patient with autoimmune pancreatitis (AIP) is presented. A 64-year-old woman was diagnosed with AIP in 2007. The symptoms resolved with prednisolone (PSL). Although the dose of PSL was tapered to 7.5 mg/day for maintenance, serum IgG4 levels remained high. She suddenly presented with subcutaneous bleeding in 2015. Her activated partial thromboplastin time was prolonged (80.0 s). A mixing test showed an inhibitor pattern, factor VIII (FVIII) activity was less than 1%, and FVIII inhibitor was 290 BU/mL. She was diagnosed with AHA. Her serum IgG4 was elevated to 133 mg/dL. She was treated first with PSL alone, but she developed bladder tamponade. Cyclophosphamide and activated prothrombin complex concentrate were combined with PSL. She then achieved hemostasis, and FVIII inhibitor disappeared. FVIII inhibitor had been detected since PSL was tapered and AHA recurred two months later. An enzyme-linked immunosorbent assay showed that the inhibitor was mainly IgG4 and IgG1. This case suggests that elevation of IgG4 may be associated with the development of both AHA and AIP.
22 schema:genre article
23 schema:isAccessibleForFree false
24 schema:isPartOf N9babdbc31e824515a316e36fb4675e44
25 Na19252cb0c7c4bd8a40928ad78537436
26 sg:journal.1076985
27 schema:keywords AHA
28 BU/
29 FVIII inhibitors
30 IgG1
31 IgG4
32 IgG4 elevation
33 IgG4 levels
34 VIII activity
35 activity
36 autoimmune pancreatitis
37 bladder tamponade
38 bleeding
39 cases
40 complex concentrate
41 concentrate
42 cyclophosphamide
43 days
44 development
45 dose
46 dose of prednisolone
47 elevation
48 elevation of IgG4
49 enzyme-linked immunosorbent
50 factor VIII activity
51 hemophilia A
52 hemostasis
53 immunosorbent
54 inhibitor pattern
55 inhibitors
56 levels
57 maintenance
58 months
59 pancreatitis
60 partial thromboplastin time
61 patients
62 patterns
63 prednisolone
64 prothrombin complex concentrate
65 serum IgG4
66 serum IgG4 elevation
67 serum IgG4 levels
68 subcutaneous bleeding
69 symptoms
70 tamponade
71 test
72 thromboplastin time
73 time
74 women
75 schema:name Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation
76 schema:pagination 335-338
77 schema:productId N25b2745a276448f9ba85e3fcd798b2f3
78 N47bb754607e64ba3b4a727a25f94cbc9
79 Nc9ec9ed79923408abac67fd0365b588d
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101768686
81 https://doi.org/10.1007/s12185-018-2441-3
82 schema:sdDatePublished 2022-11-24T21:03
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N95f9211d947744239f29349ed2b713ae
85 schema:url https://doi.org/10.1007/s12185-018-2441-3
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N08a997930ea34baba9017309dd7baa13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Autoimmune Diseases
91 rdf:type schema:DefinedTerm
92 N0ba6de6a28234c4cb3041dda8a39cc71 rdf:first sg:person.01155405322.52
93 rdf:rest Na2d47054baa7480cb3108a0b2036cc7f
94 N11c4ffc1343e46749c774471594b5749 rdf:first sg:person.01131607430.61
95 rdf:rest N0ba6de6a28234c4cb3041dda8a39cc71
96 N16f13638054c4926ad6d2ddc05df9f74 rdf:first sg:person.01276201766.85
97 rdf:rest N11c4ffc1343e46749c774471594b5749
98 N22d4fc12f0ff4b23a0798fca03b39b4e rdf:first sg:person.010710762630.87
99 rdf:rest Nbb35f78b34c44288b1f2ff290a933ed9
100 N25b2745a276448f9ba85e3fcd798b2f3 schema:name dimensions_id
101 schema:value pub.1101768686
102 rdf:type schema:PropertyValue
103 N2940b8d605c148b5977b5de8f54cfd05 rdf:first sg:person.0617363734.55
104 rdf:rest N16f13638054c4926ad6d2ddc05df9f74
105 N2a3cb6203f4f499a9107e76101094af2 rdf:first sg:person.013660263332.01
106 rdf:rest Nab6f6f4d79014e2f80c4ea34795ad0eb
107 N30e583c715914eefafbc63e595e41524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Middle Aged
109 rdf:type schema:DefinedTerm
110 N41db13260ffd452c9293a368a1e3c447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Pancreatitis
112 rdf:type schema:DefinedTerm
113 N47bb754607e64ba3b4a727a25f94cbc9 schema:name doi
114 schema:value 10.1007/s12185-018-2441-3
115 rdf:type schema:PropertyValue
116 N48581a26769e4b5d975363d4afd2d1da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Prednisolone
118 rdf:type schema:DefinedTerm
119 N4c1a6ed303bd484889853fdabbae7517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Biomarkers
121 rdf:type schema:DefinedTerm
122 N5b4d33f8416843cfb839e420d0b7f448 rdf:first sg:person.0705772523.06
123 rdf:rest N6fd325c266b241198fc8946276d0a090
124 N624fc7e9ada6456c90fb82f8e1f10480 rdf:first sg:person.0603447532.27
125 rdf:rest N5b4d33f8416843cfb839e420d0b7f448
126 N63cbe962a25040a599bbea241861c11d rdf:first sg:person.01053527727.79
127 rdf:rest rdf:nil
128 N6fd325c266b241198fc8946276d0a090 rdf:first sg:person.01073553516.07
129 rdf:rest N63cbe962a25040a599bbea241861c11d
130 N95f9211d947744239f29349ed2b713ae schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N9babdbc31e824515a316e36fb4675e44 schema:issueNumber 3
133 rdf:type schema:PublicationIssue
134 N9cc8300f03a44bce9ef0f7fb593aa749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Hemophilia A
136 rdf:type schema:DefinedTerm
137 Na19252cb0c7c4bd8a40928ad78537436 schema:volumeNumber 108
138 rdf:type schema:PublicationVolume
139 Na2d47054baa7480cb3108a0b2036cc7f rdf:first sg:person.0742772162.09
140 rdf:rest N624fc7e9ada6456c90fb82f8e1f10480
141 Na32b11ba254f44e384b4b2fd45588a40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Immunoglobulin G
143 rdf:type schema:DefinedTerm
144 Nab6f6f4d79014e2f80c4ea34795ad0eb rdf:first sg:person.010005617251.09
145 rdf:rest N2940b8d605c148b5977b5de8f54cfd05
146 Nad1806cbb1cb4d01a293c2b5a37654fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Blood Coagulation Factor Inhibitors
148 rdf:type schema:DefinedTerm
149 Nbb35f78b34c44288b1f2ff290a933ed9 rdf:first sg:person.0665477134.12
150 rdf:rest N2a3cb6203f4f499a9107e76101094af2
151 Nc9ec9ed79923408abac67fd0365b588d schema:name pubmed_id
152 schema:value 29582334
153 rdf:type schema:PropertyValue
154 Ncc87914c5c72496c9f01fcff725e229c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Nd37354c50b6e4c39852e2a2cb3d7f58f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 Ndef15994fa054fbc8c7261b796b96b9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Factor VIII
162 rdf:type schema:DefinedTerm
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
167 schema:name Clinical Sciences
168 rdf:type schema:DefinedTerm
169 sg:grant.6835617 http://pending.schema.org/fundedItem sg:pub.10.1007/s12185-018-2441-3
170 rdf:type schema:MonetaryGrant
171 sg:journal.1076985 schema:issn 0925-5710
172 1865-3774
173 schema:name International Journal of Hematology
174 schema:publisher Springer Nature
175 rdf:type schema:Periodical
176 sg:person.010005617251.09 schema:affiliation grid-institutes:grid.177174.3
177 schema:familyName Tsukamoto
178 schema:givenName Yasuhiro
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010005617251.09
180 rdf:type schema:Person
181 sg:person.01053527727.79 schema:affiliation grid-institutes:grid.265073.5
182 schema:familyName Ogawa
183 schema:givenName Yoshihiro
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053527727.79
185 rdf:type schema:Person
186 sg:person.010710762630.87 schema:affiliation grid-institutes:grid.177174.3
187 schema:familyName Narazaki
188 schema:givenName Taisuke
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010710762630.87
190 rdf:type schema:Person
191 sg:person.01073553516.07 schema:affiliation grid-institutes:grid.177174.3
192 schema:familyName Shiratsuchi
193 schema:givenName Motoaki
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073553516.07
195 rdf:type schema:Person
196 sg:person.01131607430.61 schema:affiliation grid-institutes:grid.177174.3
197 schema:familyName Ohno
198 schema:givenName Hirofumi
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131607430.61
200 rdf:type schema:Person
201 sg:person.01155405322.52 schema:affiliation grid-institutes:grid.177174.3
202 schema:familyName Matsushima
203 schema:givenName Takamitsu
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155405322.52
205 rdf:type schema:Person
206 sg:person.01276201766.85 schema:affiliation grid-institutes:grid.177174.3
207 schema:familyName Takamatsu
208 schema:givenName Akiko
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276201766.85
210 rdf:type schema:Person
211 sg:person.013660263332.01 schema:affiliation grid-institutes:grid.177174.3
212 schema:familyName Nakashima
213 schema:givenName Yasuhiro
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013660263332.01
215 rdf:type schema:Person
216 sg:person.0603447532.27 schema:affiliation grid-institutes:grid.410814.8
217 schema:familyName Nogami
218 schema:givenName Keiji
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603447532.27
220 rdf:type schema:Person
221 sg:person.0617363734.55 schema:affiliation grid-institutes:grid.177174.3
222 schema:familyName Tsuda
223 schema:givenName Mariko
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617363734.55
225 rdf:type schema:Person
226 sg:person.0665477134.12 schema:affiliation grid-institutes:grid.177174.3
227 schema:familyName Haji
228 schema:givenName Shojiro
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665477134.12
230 rdf:type schema:Person
231 sg:person.0705772523.06 schema:affiliation grid-institutes:grid.410814.8
232 schema:familyName Shima
233 schema:givenName Midori
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705772523.06
235 rdf:type schema:Person
236 sg:person.0742772162.09 schema:affiliation grid-institutes:grid.410814.8
237 schema:familyName Matsumoto
238 schema:givenName Tomoko
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742772162.09
240 rdf:type schema:Person
241 sg:pub.10.1007/s00535-006-1862-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053147905
242 https://doi.org/10.1007/s00535-006-1862-6
243 rdf:type schema:CreativeWork
244 sg:pub.10.1007/s00535-006-1868-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023269678
245 https://doi.org/10.1007/s00535-006-1868-0
246 rdf:type schema:CreativeWork
247 sg:pub.10.1007/s12185-016-2108-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047393459
248 https://doi.org/10.1007/s12185-016-2108-x
249 rdf:type schema:CreativeWork
250 sg:pub.10.1186/1752-1947-6-63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003885192
251 https://doi.org/10.1186/1752-1947-6-63
252 rdf:type schema:CreativeWork
253 grid-institutes:grid.177174.3 schema:alternateName Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
254 schema:name Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
255 rdf:type schema:Organization
256 grid-institutes:grid.265073.5 schema:alternateName Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
257 schema:name Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
258 Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
259 rdf:type schema:Organization
260 grid-institutes:grid.410814.8 schema:alternateName Department of Pediatrics, Nara Medical University, Kashihara, Japan
261 schema:name Department of Pediatrics, Nara Medical University, Kashihara, Japan
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...