Ontology type: schema:ScholarlyArticle
2018-02-07
AUTHORSShinya Sato, Hidehiro Itonaga, Masataka Taguchi, Yasushi Sawayama, Daisuke Imanishi, Hideki Tsushima, Tomoko Hata, Yukiyoshi Moriuchi, Hiroyuki Mishima, Akira Kinoshita, Koh-ichiro Yoshiura, Yasushi Miyazaki
ABSTRACTIn acute myeloid leukemia (AML), patients may harbor pre-leukemic hematopoietic stem cells (HSCs) containing some, but not all, of the mutations observed in the leukemic cells. These pre-leukemic HSCs may survive induction chemotherapy and contribute to AML relapse by obtaining additional mutations. We report here an acute monoblastic leukemia (AMoL) patient who later developed an unclassifiable myeloproliferative neoplasm (MPN-U). Whole-exome sequencing and cluster analysis demonstrated the presence of three distinct major clones during the clinical course: (1) an AMoL clone with ASXL1, CBL, and NPM1 somatic mutations, likely associated with the pathogenesis, and GATA2, SRSF2, and TET2 mutations, (2) an AMoL remission clone, with mutated GATA2, SRSF2, and TET2 only (possibly the founding clone (pre-leukemic HSC) that survived chemotherapy), (3) a small subclone which had JAK2 mutation during the AMoL remission, appearing at MPN-U manifestation with additional mutations. These findings suggest that pre-leukemic HSCs in AML patients may give rise to non-AML myeloid malignancies. This is the first report to analyze the clonal evolution from AMoL to MPN-U, which may provide new insight into the development of myeloid malignancies. More... »
PAGES213-217
http://scigraph.springernature.com/pub.10.1007/s12185-018-2419-1
DOIhttp://dx.doi.org/10.1007/s12185-018-2419-1
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1100859804
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29417354
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Clonal Evolution",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoietic Stem Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Induction Chemotherapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Monocytic, Acute",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Myeloproliferative Disorders",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Recurrence, Local",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nucleophosmin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Whole Exome Sequencing",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.411873.8",
"name": [
"Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Sato",
"givenName": "Shinya",
"id": "sg:person.01223547202.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223547202.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.411873.8",
"name": [
"Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Itonaga",
"givenName": "Hidehiro",
"id": "sg:person.01221607161.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221607161.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Sasebo City General Hospital, Sasebo, Japan",
"id": "http://www.grid.ac/institutes/grid.415288.2",
"name": [
"Department of Hematology, Sasebo City General Hospital, Sasebo, Japan"
],
"type": "Organization"
},
"familyName": "Taguchi",
"givenName": "Masataka",
"id": "sg:person.01163073736.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163073736.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.411873.8",
"name": [
"Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Sawayama",
"givenName": "Yasushi",
"id": "sg:person.01203535355.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203535355.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Goto Central Hospital, Goto, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Goto Central Hospital, Goto, Japan"
],
"type": "Organization"
},
"familyName": "Imanishi",
"givenName": "Daisuke",
"id": "sg:person.0673127034.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673127034.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Tsushima",
"givenName": "Hideki",
"id": "sg:person.0632143365.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632143365.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.411873.8",
"name": [
"Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Hata",
"givenName": "Tomoko",
"id": "sg:person.01014505165.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014505165.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Sasebo City General Hospital, Sasebo, Japan",
"id": "http://www.grid.ac/institutes/grid.415288.2",
"name": [
"Department of Hematology, Sasebo City General Hospital, Sasebo, Japan"
],
"type": "Organization"
},
"familyName": "Moriuchi",
"givenName": "Yukiyoshi",
"id": "sg:person.01227410302.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227410302.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Human Genetics, Atomic Bomb Disease Insutitute, Nagasaki University, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.174567.6",
"name": [
"Department of Human Genetics, Atomic Bomb Disease Insutitute, Nagasaki University, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Mishima",
"givenName": "Hiroyuki",
"id": "sg:person.0643355356.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643355356.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Human Genetics, Atomic Bomb Disease Insutitute, Nagasaki University, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.174567.6",
"name": [
"Department of Human Genetics, Atomic Bomb Disease Insutitute, Nagasaki University, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Kinoshita",
"givenName": "Akira",
"id": "sg:person.01052227366.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052227366.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Human Genetics, Atomic Bomb Disease Insutitute, Nagasaki University, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.174567.6",
"name": [
"Department of Human Genetics, Atomic Bomb Disease Insutitute, Nagasaki University, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Yoshiura",
"givenName": "Koh-ichiro",
"id": "sg:person.01304011603.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304011603.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.174567.6",
"name": [
"Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan",
"Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Miyazaki",
"givenName": "Yasushi",
"id": "sg:person.012267426162.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012267426162.55"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature10762",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053038796",
"https://doi.org/10.1038/nature10762"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07943",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004829095",
"https://doi.org/10.1038/nature07943"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.913",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001065103",
"https://doi.org/10.1038/ng.913"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10738",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003206661",
"https://doi.org/10.1038/nature10738"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature13038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015493548",
"https://doi.org/10.1038/nature13038"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.3742",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027788691",
"https://doi.org/10.1038/ng.3742"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2014.257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032563584",
"https://doi.org/10.1038/leu.2014.257"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-017-2257-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085715756",
"https://doi.org/10.1007/s12185-017-2257-6"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-02-07",
"datePublishedReg": "2018-02-07",
"description": "In acute myeloid leukemia (AML), patients may harbor pre-leukemic hematopoietic stem cells (HSCs) containing some, but not all, of the mutations observed in the leukemic cells. These pre-leukemic HSCs may survive induction chemotherapy and contribute to AML relapse by obtaining additional mutations. We report here an acute monoblastic leukemia (AMoL) patient who later developed an unclassifiable myeloproliferative neoplasm (MPN-U). Whole-exome sequencing and cluster analysis demonstrated the presence of three distinct major clones during the clinical course: (1) an AMoL clone with ASXL1, CBL, and NPM1 somatic mutations, likely associated with the pathogenesis, and GATA2, SRSF2, and TET2 mutations, (2) an AMoL remission clone, with mutated GATA2, SRSF2, and TET2 only (possibly the founding clone (pre-leukemic HSC) that survived chemotherapy), (3) a small subclone which had JAK2 mutation during the AMoL remission, appearing at MPN-U manifestation with additional mutations. These findings suggest that pre-leukemic HSCs in AML patients may give rise to non-AML myeloid malignancies. This is the first report to analyze the clonal evolution from AMoL to MPN-U, which may provide new insight into the development of myeloid malignancies.",
"genre": "article",
"id": "sg:pub.10.1007/s12185-018-2419-1",
"inLanguage": "en",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.6841611",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6149083",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5903161",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.9338740",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.9338866",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.9338674",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6822172",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.9338759",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5875677",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6536563",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1076985",
"issn": [
"0925-5710",
"1865-3774"
],
"name": "International Journal of Hematology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "108"
}
],
"keywords": [
"pre-leukemic hematopoietic stem cells",
"acute myeloid leukemia",
"hematopoietic stem cells",
"myeloproliferative neoplasms",
"myeloid malignancies",
"unclassifiable myeloproliferative neoplasm",
"acute monoblastic leukemia",
"whole-exome sequencing",
"induction chemotherapy",
"clinical course",
"AML relapse",
"AML patients",
"myeloid leukemia",
"leukemia patients",
"monoblastic leukemia",
"additional mutations",
"leukemic cells",
"TET2 mutations",
"JAK2 mutation",
"major clones",
"patients",
"malignancy",
"clonal evolution",
"neoplasms",
"somatic mutations",
"leukemia",
"stem cells",
"SRSF2",
"first report",
"mutations",
"clonal dynamics",
"small subclones",
"remission",
"cells",
"chemotherapy",
"relapse",
"GATA2",
"pathogenesis",
"ASXL1",
"manifestations",
"clones",
"TET2",
"report",
"MPN",
"findings",
"new insights",
"course",
"subclones",
"Cbl",
"cases",
"sequencing",
"presence",
"development",
"amol",
"cluster analysis",
"analysis",
"insights",
"evolution",
"dynamics"
],
"name": "Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm",
"pagination": "213-217",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1100859804"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s12185-018-2419-1"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29417354"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s12185-018-2419-1",
"https://app.dimensions.ai/details/publication/pub.1100859804"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:33",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_754.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s12185-018-2419-1"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2419-1'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2419-1'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2419-1'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-2419-1'
This table displays all metadata directly associated to this object as RDF triples.
316 TRIPLES
22 PREDICATES
106 URIs
89 LITERALS
19 BLANK NODES