Immunosuppressive therapy with rabbit antithymocyte globulin therapy for acquired aplastic anemia: a multi-institutional retrospective study in Japanese adult patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Nana Sasaki, Kazuho Shimura, Mihoko Yoshida, Nobuhiko Uoshima, Miki Kiyota, Mayumi Hatsuse, Hitoji Uchiyama, Yoshiaki Chinen, Tsutomu Kobayashi, Mitsushige Nakao, Ryoichi Takahashi, Sonoko Nakano-Akamatsu, Hiroto Kaneko, Yutaka Kobayashi, Chihiro Shimazaki, Masafumi Taniwaki, Junya Kuroda, The Kyoto Clinical Hematology Study Group (KOTOSG) investigators

ABSTRACT

We retrospectively analyzed efficacy and safety of therapy with rabbit antithymocyte globulin (rATG) in combination with cyclosporine A (CsA) in 30 Japanese adult patients with acquired aplastic anemia (AA) in the Kyoto Clinical Hematology Study Group. The median observation period was 31 months and the median age of the patients was 54 years. The objective response rates (ORRs) to rATG plus CsA increased over time until 18 months after the start of treatment; the rate of achievement of better than partial response at 18 months was 66.7%. The 2-year overall survival (OS) rate was 79% in all patients. In eight patients aged ≥ 75 years old, the ORR was 62.5% and the 2-year OS rate of 50% was not significantly inferior to that in patients aged ≤ 74 years old. The overall mortality rate was 16.7% in our cohort, while the mortality rate in patients aged ≥ 75 years old was 37.5%, which was higher than that in patients aged ≤ 74 years old (9.1%), although the difference was not statistically significant. Collectively, rATG combined with CsA is an effective and feasible treatment for AA, while patients should be appropriately selected. More... »

PAGES

278-285

References to SciGraph publications

  • 2016-10. Efficacy of rabbit antithymocyte globulin as first-line treatment of severe aplastic anemia: an Asian multicenter retrospective study in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2015-05. Efficacy of porcine antihuman lymphocyte immunoglobulin compared to rabbit antithymocyte immunoglobulin as a first-line treatment against acquired severe aplastic anemia in ANNALS OF HEMATOLOGY
  • 2004-03. A prospective, randomised, phase II study of horse antithymocyte globulin vs rabbit antithymocyte globulin as immune-modulating therapy in patients with low-risk myelodysplastic syndromes in LEUKEMIA
  • 2016-10. Efficacy of combination therapy with anti-thymocyte globulin and cyclosporine A as a first-line treatment in adult patients with aplastic anemia: a comparison of rabbit and horse formulations in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2013-09. Effectiveness and safety of rabbit anti-thymocyte globulin in Japanese patients with aplastic anemia in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2015-06. Rabbit antithymocyte globulin versus horse antithymocyte globulin for treatment of acquired aplastic anemia: a retrospective analysis in ANNALS OF HEMATOLOGY
  • 2013-05. The optimal immunosuppressive therapy for aplastic anemia in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2017-11. Predictors of early mortality after rabbit antithymocyte globulin as first-line treatment in severe aplastic anemia in ANNALS OF HEMATOLOGY
  • 2017-05. Meta-analysis of treatment with rabbit and horse antithymocyte globulin for aplastic anemia in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2013-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2018-11. Rabbit antithymocyte globulin dose does not affect response or survival as first-line therapy for acquired aplastic anemia: a multicenter retrospective study in ANNALS OF HEMATOLOGY
  • 2017-12. Horse versus rabbit antithymocyte globulin in immunosuppressive therapy of treatment-naïve aplastic anemia: a systematic review and meta-analysis in ANNALS OF HEMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-018-02583-w

    DOI

    http://dx.doi.org/10.1007/s12185-018-02583-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111312324

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30627868


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anemia, Aplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antilymphocyte Serum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Asian Continental Ancestry Group", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunosuppression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Japan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rabbits", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan", 
                "Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sasaki", 
            "givenName": "Nana", 
            "id": "sg:person.01043363335.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043363335.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimura", 
            "givenName": "Kazuho", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshida", 
            "givenName": "Mihoko", 
            "id": "sg:person.0721144022.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721144022.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Matsushita Memorial Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416591.e", 
              "name": [
                "Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan", 
                "Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uoshima", 
            "givenName": "Nobuhiko", 
            "id": "sg:person.0677311502.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677311502.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Matsushita Memorial Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416591.e", 
              "name": [
                "Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kiyota", 
            "givenName": "Miki", 
            "id": "sg:person.01016640522.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016640522.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hematology, JCHO Kyoto Kuramaguchi Medical Center, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hatsuse", 
            "givenName": "Mayumi", 
            "id": "sg:person.01317555751.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317555751.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyoto first Red Cross hospital", 
              "id": "https://www.grid.ac/institutes/grid.415604.2", 
              "name": [
                "Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uchiyama", 
            "givenName": "Hitoji", 
            "id": "sg:person.01274040335.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274040335.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyoto Prefectural University of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.272458.e", 
              "name": [
                "Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, 602-8566, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chinen", 
            "givenName": "Yoshiaki", 
            "id": "sg:person.0614464406.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614464406.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyoto Prefectural University of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.272458.e", 
              "name": [
                "Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, 602-8566, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Tsutomu", 
            "id": "sg:person.01011721267.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011721267.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Otsu Municipal Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417346.3", 
              "name": [
                "Department of Hematology, Otsu Municipal Hospital, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakao", 
            "givenName": "Mitsushige", 
            "id": "sg:person.0662577606.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662577606.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hematology, Omihachiman Community Medical Center, Omihachiman, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Ryoichi", 
            "id": "sg:person.013364336422.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013364336422.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hematology, Omihachiman Community Medical Center, Omihachiman, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakano-Akamatsu", 
            "givenName": "Sonoko", 
            "id": "sg:person.01112403435.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112403435.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaneko", 
            "givenName": "Hiroto", 
            "id": "sg:person.0757160060.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757160060.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Yutaka", 
            "id": "sg:person.011562275742.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011562275742.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hematology, JCHO Kyoto Kuramaguchi Medical Center, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimazaki", 
            "givenName": "Chihiro", 
            "id": "sg:person.01135214151.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135214151.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyoto Prefectural University of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.272458.e", 
              "name": [
                "Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan", 
                "Center for Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Taniwaki", 
            "givenName": "Masafumi", 
            "id": "sg:person.01320436003.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320436003.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyoto Prefectural University of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.272458.e", 
              "name": [
                "Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, 602-8566, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuroda", 
            "givenName": "Junya", 
            "id": "sg:person.01204610767.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204610767.63"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "The Kyoto Clinical Hematology Study Group (KOTOSG) investigators", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1159/000365546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000236194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000365546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000236194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-014-2279-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003390686", 
              "https://doi.org/10.1007/s00277-014-2279-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-04-1134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005507610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2008.07450.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006280067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-015-2305-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010043963", 
              "https://doi.org/10.1007/s00277-015-2305-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trim.2015.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010422826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-017-2179-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011465089", 
              "https://doi.org/10.1007/s12185-017-2179-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-017-2179-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011465089", 
              "https://doi.org/10.1007/s12185-017-2179-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3324/haematol.2014.106542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014223293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2009.07842.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015059630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2009.07842.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015059630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015449707", 
              "https://doi.org/10.1038/sj.leu.2403239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015449707", 
              "https://doi.org/10.1038/sj.leu.2403239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000040999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016933393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-08-304071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021236070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-016-2046-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024359935", 
              "https://doi.org/10.1007/s12185-016-2046-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-016-2046-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024359935", 
              "https://doi.org/10.1007/s12185-016-2046-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-013-1331-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036347727", 
              "https://doi.org/10.1007/s12185-013-1331-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2006.06098.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042389007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-06-2485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046242912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-013-1418-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047729760", 
              "https://doi.org/10.1007/s12185-013-1418-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1103975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050298623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-016-2053-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051139157", 
              "https://doi.org/10.1007/s12185-016-2053-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-016-2053-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051139157", 
              "https://doi.org/10.1007/s12185-016-2053-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-02-407684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051806389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074601292", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082599647", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2169/internalmedicine.56.7722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084390072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-017-3086-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091223777", 
              "https://doi.org/10.1007/s00277-017-3086-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-017-3086-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091223777", 
              "https://doi.org/10.1007/s00277-017-3086-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-017-3136-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091999878", 
              "https://doi.org/10.1007/s00277-017-3136-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajh.25081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101316262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/ejh.13057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101526635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-018-3416-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105324326", 
              "https://doi.org/10.1007/s00277-018-3416-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "We retrospectively analyzed efficacy and safety of therapy with rabbit antithymocyte globulin (rATG) in combination with cyclosporine A (CsA) in 30 Japanese adult patients with acquired aplastic anemia (AA) in the Kyoto Clinical Hematology Study Group. The median observation period was 31\u00a0months and the median age of the patients was 54\u00a0years. The objective response rates (ORRs) to rATG plus CsA increased over time until 18\u00a0months after the start of treatment; the rate of achievement of better than partial response at 18\u00a0months was 66.7%. The 2-year overall survival (OS) rate was 79% in all patients. In eight patients aged \u2265\u200975\u00a0years old, the ORR was 62.5% and the 2-year OS rate of 50% was not significantly inferior to that in patients aged \u2264\u200974\u00a0years old. The overall mortality rate was 16.7% in our cohort, while the mortality rate in patients aged \u2265\u200975\u00a0years old was 37.5%, which was higher than that in patients aged \u2264\u200974\u00a0years old (9.1%), although the difference was not statistically significant. Collectively, rATG combined with CsA is an effective and feasible treatment for AA, while patients should be appropriately selected.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12185-018-02583-w", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1076985", 
            "issn": [
              "0925-5710", 
              "1865-3774"
            ], 
            "name": "International Journal of Hematology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "109"
          }
        ], 
        "name": "Immunosuppressive therapy with rabbit antithymocyte globulin therapy for acquired aplastic anemia: a multi-institutional retrospective study in Japanese adult patients", 
        "pagination": "278-285", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b1df255d707f6a0b9967ebd47fe71d800d62458a611682de28ab5185919314f3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30627868"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9111627"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12185-018-02583-w"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111312324"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12185-018-02583-w", 
          "https://app.dimensions.ai/details/publication/pub.1111312324"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60335_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs12185-018-02583-w"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-02583-w'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-02583-w'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-02583-w'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-018-02583-w'


     

    This table displays all metadata directly associated to this object as RDF triples.

    380 TRIPLES      21 PREDICATES      75 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12185-018-02583-w schema:about N08a259c11aca403e881faa386f669596
    2 N1ab8a150844643539b208a5c44104ce0
    3 N315a86a6457c442da77ac910c8b87a6a
    4 N333f37471856493a953896f83736b366
    5 N3fb1d8066e484c1892ed30033ecc59a3
    6 N430c9c9972f3472aa4af8900db5a9f62
    7 N52ecd639a6b94fcdb8a1e4fb41b146fe
    8 N5b7e180e30d84b3c94bdf77b47a4bd52
    9 N5e93047bb6d747b7ab7a98c391831035
    10 N87f8e0d27be74be2a32eee3ba65404f4
    11 N9351aa3debc84af3b7840837373fe004
    12 N99de9c8c1bc849588aced36aabb62c12
    13 Na572d5aafccf4fada26ee13d07caad96
    14 Nccf3cddd1f6d41d89774cc575716d62a
    15 Nf0b001ddf41e4bdc9fc068a83726a21b
    16 Nf39b858a925b412e99959c8cd5e9df72
    17 Nfc6cc3d14dfc4af08bae89bdb51c5ba3
    18 anzsrc-for:11
    19 anzsrc-for:1103
    20 schema:author N65c64454af91405392bacdda50033bd2
    21 schema:citation sg:pub.10.1007/s00277-014-2279-6
    22 sg:pub.10.1007/s00277-015-2305-3
    23 sg:pub.10.1007/s00277-017-3086-7
    24 sg:pub.10.1007/s00277-017-3136-1
    25 sg:pub.10.1007/s00277-018-3416-4
    26 sg:pub.10.1007/s12185-013-1331-y
    27 sg:pub.10.1007/s12185-013-1418-5
    28 sg:pub.10.1007/s12185-016-2046-7
    29 sg:pub.10.1007/s12185-016-2053-8
    30 sg:pub.10.1007/s12185-017-2179-3
    31 sg:pub.10.1038/bmt.2012.244
    32 sg:pub.10.1038/sj.leu.2403239
    33 https://app.dimensions.ai/details/publication/pub.1074601292
    34 https://app.dimensions.ai/details/publication/pub.1082599647
    35 https://doi.org/10.1002/ajh.25081
    36 https://doi.org/10.1016/j.trim.2015.04.003
    37 https://doi.org/10.1056/nejmoa1103975
    38 https://doi.org/10.1111/ejh.13057
    39 https://doi.org/10.1111/j.1365-2141.2006.06098.x
    40 https://doi.org/10.1111/j.1365-2141.2008.07450.x
    41 https://doi.org/10.1111/j.1365-2141.2009.07842.x
    42 https://doi.org/10.1159/000040999
    43 https://doi.org/10.1159/000365546
    44 https://doi.org/10.1182/blood-2002-04-1134
    45 https://doi.org/10.1182/blood-2005-06-2485
    46 https://doi.org/10.1182/blood-2010-08-304071
    47 https://doi.org/10.1182/blood-2012-02-407684
    48 https://doi.org/10.2169/internalmedicine.56.7722
    49 https://doi.org/10.3324/haematol.2014.106542
    50 schema:datePublished 2019-03
    51 schema:datePublishedReg 2019-03-01
    52 schema:description We retrospectively analyzed efficacy and safety of therapy with rabbit antithymocyte globulin (rATG) in combination with cyclosporine A (CsA) in 30 Japanese adult patients with acquired aplastic anemia (AA) in the Kyoto Clinical Hematology Study Group. The median observation period was 31 months and the median age of the patients was 54 years. The objective response rates (ORRs) to rATG plus CsA increased over time until 18 months after the start of treatment; the rate of achievement of better than partial response at 18 months was 66.7%. The 2-year overall survival (OS) rate was 79% in all patients. In eight patients aged ≥ 75 years old, the ORR was 62.5% and the 2-year OS rate of 50% was not significantly inferior to that in patients aged ≤ 74 years old. The overall mortality rate was 16.7% in our cohort, while the mortality rate in patients aged ≥ 75 years old was 37.5%, which was higher than that in patients aged ≤ 74 years old (9.1%), although the difference was not statistically significant. Collectively, rATG combined with CsA is an effective and feasible treatment for AA, while patients should be appropriately selected.
    53 schema:genre research_article
    54 schema:inLanguage en
    55 schema:isAccessibleForFree false
    56 schema:isPartOf N64b6f6f2d8564687b9a276e81ee43c90
    57 Nbb96c13f9cc7464ebeb64988c9a5a0bd
    58 sg:journal.1076985
    59 schema:name Immunosuppressive therapy with rabbit antithymocyte globulin therapy for acquired aplastic anemia: a multi-institutional retrospective study in Japanese adult patients
    60 schema:pagination 278-285
    61 schema:productId N0ffaa76deb714bf99b24a93ab6e0850a
    62 N3c4dc69ac4aa40e7b23b3b9eac191725
    63 N40b2011066bd46a89b0c4bacdf8bb6f3
    64 N5661af1849754e488162849e71446386
    65 N95552cd62fee4b38b23979b69bab391c
    66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111312324
    67 https://doi.org/10.1007/s12185-018-02583-w
    68 schema:sdDatePublished 2019-04-11T10:59
    69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    70 schema:sdPublisher N51f295aa527149518e74a540c1b510a1
    71 schema:url https://link.springer.com/10.1007%2Fs12185-018-02583-w
    72 sgo:license sg:explorer/license/
    73 sgo:sdDataset articles
    74 rdf:type schema:ScholarlyArticle
    75 N006ed34ef6ed4979b613a3cfab1f59bd rdf:first sg:person.0757160060.84
    76 rdf:rest N69424722df774ae188eee172d94ff1d2
    77 N04b821ff48a44132be0e79c796a793c6 schema:name Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan
    78 Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan
    79 rdf:type schema:Organization
    80 N08a259c11aca403e881faa386f669596 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    81 schema:name Rabbits
    82 rdf:type schema:DefinedTerm
    83 N0ffaa76deb714bf99b24a93ab6e0850a schema:name pubmed_id
    84 schema:value 30627868
    85 rdf:type schema:PropertyValue
    86 N106735c6c9f348deab08ca4068644d31 schema:name Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan
    87 rdf:type schema:Organization
    88 N1ab8a150844643539b208a5c44104ce0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Disease-Free Survival
    90 rdf:type schema:DefinedTerm
    91 N236f5aed3d3d483f90a1e52077020847 rdf:first N448343bcc380416fac75fbaa948af093
    92 rdf:rest N997720b2bf844a6982b1a0319bc7f908
    93 N315a86a6457c442da77ac910c8b87a6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Female
    95 rdf:type schema:DefinedTerm
    96 N333f37471856493a953896f83736b366 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Asian Continental Ancestry Group
    98 rdf:type schema:DefinedTerm
    99 N349cc8e0cf4b4463bec678f69110be03 rdf:first sg:person.01204610767.63
    100 rdf:rest Nc09782918de84244abfa8895cbe319e2
    101 N3718b1719d35484698cc70aea6decfb8 schema:name Department of Hematology, Omihachiman Community Medical Center, Omihachiman, Japan
    102 rdf:type schema:Organization
    103 N3c4dc69ac4aa40e7b23b3b9eac191725 schema:name doi
    104 schema:value 10.1007/s12185-018-02583-w
    105 rdf:type schema:PropertyValue
    106 N3fb1d8066e484c1892ed30033ecc59a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Anemia, Aplastic
    108 rdf:type schema:DefinedTerm
    109 N40510bca500e4f109d373f34e26dae91 rdf:first sg:person.0677311502.47
    110 rdf:rest N70cba6a8084c4cf3bfbb6fa717c884ce
    111 N40b2011066bd46a89b0c4bacdf8bb6f3 schema:name nlm_unique_id
    112 schema:value 9111627
    113 rdf:type schema:PropertyValue
    114 N430c9c9972f3472aa4af8900db5a9f62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Aged, 80 and over
    116 rdf:type schema:DefinedTerm
    117 N448343bcc380416fac75fbaa948af093 schema:affiliation N106735c6c9f348deab08ca4068644d31
    118 schema:familyName Shimura
    119 schema:givenName Kazuho
    120 rdf:type schema:Person
    121 N5193fb3be3294dc3885d7f85ac4b1ae7 rdf:first sg:person.01112403435.74
    122 rdf:rest N006ed34ef6ed4979b613a3cfab1f59bd
    123 N51f295aa527149518e74a540c1b510a1 schema:name Springer Nature - SN SciGraph project
    124 rdf:type schema:Organization
    125 N52ecd639a6b94fcdb8a1e4fb41b146fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Japan
    127 rdf:type schema:DefinedTerm
    128 N5661af1849754e488162849e71446386 schema:name dimensions_id
    129 schema:value pub.1111312324
    130 rdf:type schema:PropertyValue
    131 N5b7e180e30d84b3c94bdf77b47a4bd52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Adult
    133 rdf:type schema:DefinedTerm
    134 N5dbc8b011e0c446c876b4d02807cb303 schema:name Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan
    135 rdf:type schema:Organization
    136 N5e93047bb6d747b7ab7a98c391831035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Antilymphocyte Serum
    138 rdf:type schema:DefinedTerm
    139 N64b6f6f2d8564687b9a276e81ee43c90 schema:issueNumber 3
    140 rdf:type schema:PublicationIssue
    141 N65c64454af91405392bacdda50033bd2 rdf:first sg:person.01043363335.37
    142 rdf:rest N236f5aed3d3d483f90a1e52077020847
    143 N69424722df774ae188eee172d94ff1d2 rdf:first sg:person.011562275742.50
    144 rdf:rest N6ab8df29ad3a4820b011adbe264e784a
    145 N6ab8df29ad3a4820b011adbe264e784a rdf:first sg:person.01135214151.73
    146 rdf:rest Ne74815653434461ea4cd75689b82aeb4
    147 N70cba6a8084c4cf3bfbb6fa717c884ce rdf:first sg:person.01016640522.88
    148 rdf:rest N88935e0182f8425aa7825355e4689d1e
    149 N7b61f848d8404f7d845a564f34b4acdb rdf:first sg:person.01011721267.74
    150 rdf:rest Nb9a71f2d8bcb4f79bc2c455d7775913d
    151 N87f8e0d27be74be2a32eee3ba65404f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Animals
    153 rdf:type schema:DefinedTerm
    154 N88935e0182f8425aa7825355e4689d1e rdf:first sg:person.01317555751.13
    155 rdf:rest N99fc40636c064502817d88d2ce9203dd
    156 N8971aba934f04f369d933209faf6ebd9 rdf:first sg:person.0614464406.50
    157 rdf:rest N7b61f848d8404f7d845a564f34b4acdb
    158 N8b0c33983c0c4ccbae9a4109ef1233f1 schema:name Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan
    159 rdf:type schema:Organization
    160 N9084960c915547059e0f086933efbde3 schema:name Department of Hematology, JCHO Kyoto Kuramaguchi Medical Center, Kyoto, Japan
    161 rdf:type schema:Organization
    162 N9217857790ff48c2b3215e7493f91c1d schema:name Department of Hematology, Omihachiman Community Medical Center, Omihachiman, Japan
    163 rdf:type schema:Organization
    164 N9351aa3debc84af3b7840837373fe004 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Middle Aged
    166 rdf:type schema:DefinedTerm
    167 N95552cd62fee4b38b23979b69bab391c schema:name readcube_id
    168 schema:value b1df255d707f6a0b9967ebd47fe71d800d62458a611682de28ab5185919314f3
    169 rdf:type schema:PropertyValue
    170 N997720b2bf844a6982b1a0319bc7f908 rdf:first sg:person.0721144022.57
    171 rdf:rest N40510bca500e4f109d373f34e26dae91
    172 N99de9c8c1bc849588aced36aabb62c12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Aged
    174 rdf:type schema:DefinedTerm
    175 N99fc40636c064502817d88d2ce9203dd rdf:first sg:person.01274040335.15
    176 rdf:rest N8971aba934f04f369d933209faf6ebd9
    177 Na572d5aafccf4fada26ee13d07caad96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Survival Rate
    179 rdf:type schema:DefinedTerm
    180 Naf89f6db1f874335899e04cd65f89ea9 rdf:first sg:person.013364336422.06
    181 rdf:rest N5193fb3be3294dc3885d7f85ac4b1ae7
    182 Nb9a71f2d8bcb4f79bc2c455d7775913d rdf:first sg:person.0662577606.23
    183 rdf:rest Naf89f6db1f874335899e04cd65f89ea9
    184 Nbb96c13f9cc7464ebeb64988c9a5a0bd schema:volumeNumber 109
    185 rdf:type schema:PublicationVolume
    186 Nc09782918de84244abfa8895cbe319e2 rdf:first Nd095f1de61a9429fbf3e9f71fac7e6ff
    187 rdf:rest rdf:nil
    188 Nc7d373bfc4414810b808f0720e6e45f2 schema:name Department of Hematology, JCHO Kyoto Kuramaguchi Medical Center, Kyoto, Japan
    189 rdf:type schema:Organization
    190 Nccf3cddd1f6d41d89774cc575716d62a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Retrospective Studies
    192 rdf:type schema:DefinedTerm
    193 Nd095f1de61a9429fbf3e9f71fac7e6ff schema:familyName The Kyoto Clinical Hematology Study Group (KOTOSG) investigators
    194 rdf:type schema:Person
    195 Ne74815653434461ea4cd75689b82aeb4 rdf:first sg:person.01320436003.92
    196 rdf:rest N349cc8e0cf4b4463bec678f69110be03
    197 Nf0b001ddf41e4bdc9fc068a83726a21b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Immunosuppression
    199 rdf:type schema:DefinedTerm
    200 Nf31101acab684d5ca4ee0837bf8a25d4 schema:name Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan
    201 rdf:type schema:Organization
    202 Nf39b858a925b412e99959c8cd5e9df72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Humans
    204 rdf:type schema:DefinedTerm
    205 Nfc6cc3d14dfc4af08bae89bdb51c5ba3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Male
    207 rdf:type schema:DefinedTerm
    208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    209 schema:name Medical and Health Sciences
    210 rdf:type schema:DefinedTerm
    211 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Clinical Sciences
    213 rdf:type schema:DefinedTerm
    214 sg:journal.1076985 schema:issn 0925-5710
    215 1865-3774
    216 schema:name International Journal of Hematology
    217 rdf:type schema:Periodical
    218 sg:person.01011721267.74 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
    219 schema:familyName Kobayashi
    220 schema:givenName Tsutomu
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011721267.74
    222 rdf:type schema:Person
    223 sg:person.01016640522.88 schema:affiliation https://www.grid.ac/institutes/grid.416591.e
    224 schema:familyName Kiyota
    225 schema:givenName Miki
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016640522.88
    227 rdf:type schema:Person
    228 sg:person.01043363335.37 schema:affiliation N04b821ff48a44132be0e79c796a793c6
    229 schema:familyName Sasaki
    230 schema:givenName Nana
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043363335.37
    232 rdf:type schema:Person
    233 sg:person.01112403435.74 schema:affiliation N3718b1719d35484698cc70aea6decfb8
    234 schema:familyName Nakano-Akamatsu
    235 schema:givenName Sonoko
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112403435.74
    237 rdf:type schema:Person
    238 sg:person.01135214151.73 schema:affiliation N9084960c915547059e0f086933efbde3
    239 schema:familyName Shimazaki
    240 schema:givenName Chihiro
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135214151.73
    242 rdf:type schema:Person
    243 sg:person.011562275742.50 schema:affiliation N5dbc8b011e0c446c876b4d02807cb303
    244 schema:familyName Kobayashi
    245 schema:givenName Yutaka
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011562275742.50
    247 rdf:type schema:Person
    248 sg:person.01204610767.63 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
    249 schema:familyName Kuroda
    250 schema:givenName Junya
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204610767.63
    252 rdf:type schema:Person
    253 sg:person.01274040335.15 schema:affiliation https://www.grid.ac/institutes/grid.415604.2
    254 schema:familyName Uchiyama
    255 schema:givenName Hitoji
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274040335.15
    257 rdf:type schema:Person
    258 sg:person.01317555751.13 schema:affiliation Nc7d373bfc4414810b808f0720e6e45f2
    259 schema:familyName Hatsuse
    260 schema:givenName Mayumi
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317555751.13
    262 rdf:type schema:Person
    263 sg:person.01320436003.92 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
    264 schema:familyName Taniwaki
    265 schema:givenName Masafumi
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320436003.92
    267 rdf:type schema:Person
    268 sg:person.013364336422.06 schema:affiliation N9217857790ff48c2b3215e7493f91c1d
    269 schema:familyName Takahashi
    270 schema:givenName Ryoichi
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013364336422.06
    272 rdf:type schema:Person
    273 sg:person.0614464406.50 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
    274 schema:familyName Chinen
    275 schema:givenName Yoshiaki
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614464406.50
    277 rdf:type schema:Person
    278 sg:person.0662577606.23 schema:affiliation https://www.grid.ac/institutes/grid.417346.3
    279 schema:familyName Nakao
    280 schema:givenName Mitsushige
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662577606.23
    282 rdf:type schema:Person
    283 sg:person.0677311502.47 schema:affiliation https://www.grid.ac/institutes/grid.416591.e
    284 schema:familyName Uoshima
    285 schema:givenName Nobuhiko
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677311502.47
    287 rdf:type schema:Person
    288 sg:person.0721144022.57 schema:affiliation N8b0c33983c0c4ccbae9a4109ef1233f1
    289 schema:familyName Yoshida
    290 schema:givenName Mihoko
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721144022.57
    292 rdf:type schema:Person
    293 sg:person.0757160060.84 schema:affiliation Nf31101acab684d5ca4ee0837bf8a25d4
    294 schema:familyName Kaneko
    295 schema:givenName Hiroto
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757160060.84
    297 rdf:type schema:Person
    298 sg:pub.10.1007/s00277-014-2279-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003390686
    299 https://doi.org/10.1007/s00277-014-2279-6
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s00277-015-2305-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010043963
    302 https://doi.org/10.1007/s00277-015-2305-3
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/s00277-017-3086-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091223777
    305 https://doi.org/10.1007/s00277-017-3086-7
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s00277-017-3136-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091999878
    308 https://doi.org/10.1007/s00277-017-3136-1
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s00277-018-3416-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105324326
    311 https://doi.org/10.1007/s00277-018-3416-4
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/s12185-013-1331-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1036347727
    314 https://doi.org/10.1007/s12185-013-1331-y
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1007/s12185-013-1418-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047729760
    317 https://doi.org/10.1007/s12185-013-1418-5
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1007/s12185-016-2046-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024359935
    320 https://doi.org/10.1007/s12185-016-2046-7
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1007/s12185-016-2053-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051139157
    323 https://doi.org/10.1007/s12185-016-2053-8
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1007/s12185-017-2179-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011465089
    326 https://doi.org/10.1007/s12185-017-2179-3
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    329 https://doi.org/10.1038/bmt.2012.244
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/sj.leu.2403239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015449707
    332 https://doi.org/10.1038/sj.leu.2403239
    333 rdf:type schema:CreativeWork
    334 https://app.dimensions.ai/details/publication/pub.1074601292 schema:CreativeWork
    335 https://app.dimensions.ai/details/publication/pub.1082599647 schema:CreativeWork
    336 https://doi.org/10.1002/ajh.25081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101316262
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/j.trim.2015.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010422826
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1056/nejmoa1103975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050298623
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1111/ejh.13057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101526635
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1111/j.1365-2141.2006.06098.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042389007
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1111/j.1365-2141.2008.07450.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006280067
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1111/j.1365-2141.2009.07842.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015059630
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1159/000040999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016933393
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1159/000365546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000236194
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1182/blood-2002-04-1134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005507610
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1182/blood-2005-06-2485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046242912
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1182/blood-2010-08-304071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021236070
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1182/blood-2012-02-407684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051806389
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.2169/internalmedicine.56.7722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084390072
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.3324/haematol.2014.106542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014223293
    365 rdf:type schema:CreativeWork
    366 https://www.grid.ac/institutes/grid.272458.e schema:alternateName Kyoto Prefectural University of Medicine
    367 schema:name Center for Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    368 Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan
    369 Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, 602-8566, Kyoto, Japan
    370 rdf:type schema:Organization
    371 https://www.grid.ac/institutes/grid.415604.2 schema:alternateName Kyoto first Red Cross hospital
    372 schema:name Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
    373 rdf:type schema:Organization
    374 https://www.grid.ac/institutes/grid.416591.e schema:alternateName Matsushita Memorial Hospital
    375 schema:name Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan
    376 Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan
    377 rdf:type schema:Organization
    378 https://www.grid.ac/institutes/grid.417346.3 schema:alternateName Otsu Municipal Hospital
    379 schema:name Department of Hematology, Otsu Municipal Hospital, Otsu, Japan
    380 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...