Imbalanced expression of polycistronic miRNA in acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-22

AUTHORS

Ryutaro Kotaki, Hiroshi Higuchi, Daisuke Ogiya, Yasuhiro Katahira, Natsumi Kurosaki, Naoko Yukihira, Jun Ogata, Haruna Yamamoto, Syakira Mohamad Alba, Azran Azhim, Tatsuo Kitajima, Shigeaki Inoue, Kazuhiro Morishita, Koh Ono, Ryo Koyama-Nasu, Ai Kotani

ABSTRACT

miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reported that miR-1 is oncogenic in the case of acute myeloid leukemia (AML). Here, we show that expression of miR-1 and miR-133, which have distinct functions, is differentially regulated between AML cell lines. Interestingly, the expression of miR-1 and EVI1, which binds to the promoter of the miR-1/miR-133 cluster, is correlative. The expression levels of TDP-43, an RNA-binding protein that has been reported to increase the expression, but inhibits the activity, of miR-1, were not correlated with expression levels of miR-1 in AML cells. Taken together, our observations raise the possibility that the balance of polycistronic miRNAs is regulated post-transcriptionally in a hierarchical manner possibly involving EVI1, suggesting that the deregulation of this balance may play some role in AML cells with high EVI1 expression. More... »

PAGES

811-819

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-017-2314-1

DOI

http://dx.doi.org/10.1007/s12185-017-2314-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091285887

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28831750


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25 schema:description AbstractmiR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reported that miR-1 is oncogenic in the case of acute myeloid leukemia (AML). Here, we show that expression of miR-1 and miR-133, which have distinct functions, is differentially regulated between AML cell lines. Interestingly, the expression of miR-1 and EVI1, which binds to the promoter of the miR-1/miR-133 cluster, is correlative. The expression levels of TDP-43, an RNA-binding protein that has been reported to increase the expression, but inhibits the activity, of miR-1, were not correlated with expression levels of miR-1 in AML cells. Taken together, our observations raise the possibility that the balance of polycistronic miRNAs is regulated post-transcriptionally in a hierarchical manner possibly involving EVI1, suggesting that the deregulation of this balance may play some role in AML cells with high EVI1 expression.
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32 AML cells
33 EVI1 expression
34 Ecotropic virus integration site-1
35 RNA-binding protein
36 TDP-43
37 activity
38 acute myeloid leukemia
39 anti-tumorigenic potential
40 balance
41 cases
42 cell lines
43 cells
44 chromosomal loci
45 clusters
46 deregulation
47 distinct functions
48 expression
49 expression levels
50 function
51 hierarchical manner
52 high EVI1 expression
53 imbalanced expression
54 leukemia
55 levels
56 lines
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58 manner
59 miR
60 miR-1
61 miR-1/miR
62 miR-133
63 miRNA
64 miRNAs
65 myeloid leukemia
66 observations
67 polycistronic miRNAs
68 possibility
69 post
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71 promoter
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