Use of mycophenolate mofetil and a calcineurin inhibitor in allogeneic hematopoietic stem-cell transplantation from HLA-matched siblings or unrelated volunteer donors: ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12-09

AUTHORS

Takahiko Nakane, Hirohisa Nakamae, Takuhiro Yamaguchi, Saiko Kurosawa, Atsuo Okamura, Michihiro Hidaka, Shigeo Fuji, Akio Kohno, Takeshi Saito, Yasutaka Aoyama, Kazuo Hatanaka, Yoshio Katayama, Kimikazu Yakushijin, Toshimitsu Matsui, Motohiro Yamamori, Akiyoshi Takami, Masayuki Hino, Takahiro Fukuda

ABSTRACT

To test the feasibility of mycophenolate mofetil (MMF) for graft-versus-host disease (GVHD) prophylaxis in Japanese patients, we conducted two multicenter prospective phase II trials of allogeneic hematopoietic stem-cell transplantation (HSCT) from HLA-matched related donors (MRD group) with MMF and cyclosporine or HLA 7–8/8 allele-matched unrelated bone-marrow donors (URD group) with MMF and tacrolimus. The cumulative incidences of grade II–IV acute GVHD on day 100, which was the primary endpoint in these trials, were 45.0% (90% CI 25.8–62.5) and 25.8% (90% CI 13.9–39.5) in the MRD (n = 20) and URD (n = 31) groups, respectively. The rates of 3-year overall survival and non-relapse mortality were 80.0 and 15.0% in the MRD group and 74.2 and 6.5% in the URD group, respectively. GVHD prophylaxis with MMF may lead to a lower incidence of severe mucositis and faster neutrophil engraftment compared to that with methotrexate. A pharmacokinetics study of mycophenolic acid (MPA) showed that a relatively higher plasma concentration of MPA was associated with a lower incidence of acute GVHD. In conclusion, the results of these studies suggest that GVHD prophylaxis with MMF may be useful as an alternative in Japanese patients who may benefit from faster engraftment or less severe mucositis after allogeneic HSCT. More... »

PAGES

485-496

References to SciGraph publications

  • 2004-04-05. Cyclosporine and mycophenolate mofetil prophylaxis with fludarabine and melphalan conditioning for unrelated donor transplantation: a prospective study of 22 patients with hematologic malignancies in BONE MARROW TRANSPLANTATION
  • 2006-05-01. Stable Engraftment after a Conditioning Regimen with Fludarabine and Melphalan for Bone Marrow Transplantation from an Unrelated Donor in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2010-02-08. MTX or mycophenolate mofetil with CsA as GVHD prophylaxis after reduced-intensity conditioning PBSCT from HLA-identical siblings in BONE MARROW TRANSPLANTATION
  • 2012-05-17. Mycophenolate mofetil: fully utilizing its benefits for GvHD prophylaxis in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2013-10-04. Reduced-intensity conditioning regimen with low-dose ATG-F for unrelated bone marrow transplant is associated with lower non-relapse mortality than a regimen with low-dose TBI: a single-center retrospective analysis of 103 cases in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2004-03-18. Effect of graft-versus-host disease on the outcome of bone marrow transplantation from an HLA-identical sibling donor using GVHD prophylaxis with cyclosporin A and methotrexate in LEUKEMIA
  • 2004-08-09. A prospective randomized trial comparing cyclosporine and short course methotrexate with cyclosporine and mycophenolate mofetil for GVHD prophylaxis in myeloablative allogeneic bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 2011-04-05. Use of mycophenolate mofetil in patients received allogeneic hematopoietic stem cell transplantation in Japan in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2005-04-11. Cyclosporine A and Mycophenolate Mofetil vs Cyclosporine A and Methotrexate for graft-versus-host disease prophylaxis after stem cell transplantation from HLA-identical siblings in BONE MARROW TRANSPLANTATION
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2011-03-12. Reduced-intensity conditioning by fludarabine/busulfan without additional irradiation or T-cell depletion leads to low non-relapse mortality in unrelated bone marrow transplantation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2008-05-14. Pharmacokinetics-based optimal dose-exploration of mycophenolate mofetil in allogeneic hematopoietic stem cell transplantation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2011-07-14. Pharmacokinetics-based optimal dose prediction of donor source-dependent response to mycophenolate mofetil in unrelated hematopoietic cell transplantation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • Journal

    TITLE

    International Journal of Hematology

    ISSUE

    4

    VOLUME

    105

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-016-2154-4

    DOI

    http://dx.doi.org/10.1007/s12185-016-2154-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016361753

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27943166


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcineurin Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Graft Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Graft vs Host Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HLA Antigens", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histocompatibility", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Japan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mucositis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mycophenolic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Siblings", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation, Homologous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Unrelated Donors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Volunteers", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261445.0", 
              "name": [
                "Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakane", 
            "givenName": "Takahiko", 
            "id": "sg:person.01324645723.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324645723.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261445.0", 
              "name": [
                "Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamae", 
            "givenName": "Hirohisa", 
            "id": "sg:person.01014223462.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biostatistics, Tohoku University Graduate School of Medicine, Miyagi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Biostatistics, Tohoku University Graduate School of Medicine, Miyagi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamaguchi", 
            "givenName": "Takuhiro", 
            "id": "sg:person.011640722042.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011640722042.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kurosawa", 
            "givenName": "Saiko", 
            "id": "sg:person.01302400655.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302400655.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411102.7", 
              "name": [
                "Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okamura", 
            "givenName": "Atsuo", 
            "id": "sg:person.01117233146.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117233146.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415538.e", 
              "name": [
                "Department of Hematology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hidaka", 
            "givenName": "Michihiro", 
            "id": "sg:person.01071077443.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071077443.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fuji", 
            "givenName": "Shigeo", 
            "id": "sg:person.0766701355.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766701355.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, JA Aichi Konan Kosei Hospital, Konan, Japan", 
              "id": "http://www.grid.ac/institutes/grid.459633.e", 
              "name": [
                "Department of Hematology and Oncology, JA Aichi Konan Kosei Hospital, Konan, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kohno", 
            "givenName": "Akio", 
            "id": "sg:person.01171543443.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171543443.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saito", 
            "givenName": "Takeshi", 
            "id": "sg:person.015754574322.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015754574322.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Seichokai Fuchu Hospital, Izumi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.472010.0", 
              "name": [
                "Department of Hematology, Seichokai Fuchu Hospital, Izumi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aoyama", 
            "givenName": "Yasutaka", 
            "id": "sg:person.0746110262.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746110262.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology/Oncology, Wakayama Medical University Hospital, Wakayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412857.d", 
              "name": [
                "Department of Hematology/Oncology, Wakayama Medical University Hospital, Wakayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hatanaka", 
            "givenName": "Kazuo", 
            "id": "sg:person.01241556073.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241556073.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.31432.37", 
              "name": [
                "Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Katayama", 
            "givenName": "Yoshio", 
            "id": "sg:person.01155140523.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155140523.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411102.7", 
              "name": [
                "Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yakushijin", 
            "givenName": "Kimikazu", 
            "id": "sg:person.0625717355.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625717355.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.31432.37", 
              "name": [
                "Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsui", 
            "givenName": "Toshimitsu", 
            "id": "sg:person.013316550132.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013316550132.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women\u2019s University, Hyogo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260338.c", 
              "name": [
                "Department of Clinical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women\u2019s University, Hyogo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamamori", 
            "givenName": "Motohiro", 
            "id": "sg:person.01055256533.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055256533.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411234.1", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takami", 
            "givenName": "Akiyoshi", 
            "id": "sg:person.0577702220.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261445.0", 
              "name": [
                "Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hino", 
            "givenName": "Masayuki", 
            "id": "sg:person.0777446051.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777446051.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukuda", 
            "givenName": "Takahiro", 
            "id": "sg:person.016452523632.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.bmt.1704956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035693959", 
              "https://doi.org/10.1038/sj.bmt.1704956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.05168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008968516", 
              "https://doi.org/10.1532/ijh97.05168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-012-1086-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049970375", 
              "https://doi.org/10.1007/s12185-012-1086-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1704647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015331321", 
              "https://doi.org/10.1038/sj.bmt.1704647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-011-0817-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027164270", 
              "https://doi.org/10.1007/s12185-011-0817-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-013-1449-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002022637", 
              "https://doi.org/10.1007/s12185-013-1449-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034199655", 
              "https://doi.org/10.1038/sj.leu.2403343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-011-0805-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003989070", 
              "https://doi.org/10.1007/s12185-011-0805-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-008-0093-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002235097", 
              "https://doi.org/10.1007/s12185-008-0093-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2009.362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025829761", 
              "https://doi.org/10.1038/bmt.2009.362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-011-0888-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049134449", 
              "https://doi.org/10.1007/s12185-011-0888-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1704493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017083267", 
              "https://doi.org/10.1038/sj.bmt.1704493"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-12-09", 
        "datePublishedReg": "2016-12-09", 
        "description": "To test the feasibility of mycophenolate mofetil (MMF) for graft-versus-host disease (GVHD) prophylaxis in Japanese patients, we conducted two multicenter prospective phase II trials of allogeneic hematopoietic stem-cell transplantation (HSCT) from HLA-matched related donors (MRD group) with MMF and cyclosporine or HLA 7\u20138/8 allele-matched unrelated bone-marrow donors (URD group) with MMF and tacrolimus. The cumulative incidences of grade II\u2013IV acute GVHD on day 100, which was the primary endpoint in these trials, were 45.0% (90% CI 25.8\u201362.5) and 25.8% (90% CI 13.9\u201339.5) in the MRD (n\u00a0=\u00a020) and URD (n\u00a0=\u00a031) groups, respectively. The rates of 3-year overall survival and non-relapse mortality were 80.0 and 15.0% in the MRD group and 74.2 and 6.5% in the URD group, respectively. GVHD prophylaxis with MMF may lead to a lower incidence of severe mucositis and faster neutrophil engraftment compared to that with methotrexate. A pharmacokinetics study of mycophenolic acid (MPA) showed that a relatively higher plasma concentration of MPA was associated with a lower incidence of acute GVHD. In conclusion, the results of these studies suggest that GVHD prophylaxis with MMF may be useful as an alternative in Japanese patients who may benefit from faster engraftment or less severe mucositis after allogeneic HSCT.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12185-016-2154-4", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.9340323", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1076985", 
            "issn": [
              "0925-5710", 
              "1865-3774"
            ], 
            "name": "International Journal of Hematology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "105"
          }
        ], 
        "keywords": [
          "hematopoietic stem cell transplantation", 
          "allogeneic hematopoietic stem cell transplantation", 
          "mycophenolate mofetil", 
          "phase II trial", 
          "stem cell transplantation", 
          "acute GVHD", 
          "severe mucositis", 
          "II trial", 
          "mycophenolic acid", 
          "Japanese patients", 
          "URD group", 
          "lower incidence", 
          "multicenter prospective phase II trial", 
          "prospective phase II trial", 
          "multicenter phase II trial", 
          "unrelated bone marrow donors", 
          "host disease (GVHD) prophylaxis", 
          "non-relapse mortality", 
          "unrelated volunteer donors", 
          "higher plasma concentrations", 
          "bone marrow donors", 
          "primary endpoint", 
          "neutrophil engraftment", 
          "faster engraftment", 
          "cumulative incidence", 
          "overall survival", 
          "MRD group", 
          "disease prophylaxis", 
          "related donors", 
          "calcineurin inhibitors", 
          "grade II", 
          "plasma concentrations", 
          "day 100", 
          "volunteer donors", 
          "prophylaxis", 
          "pharmacokinetic study", 
          "incidence", 
          "GVHD", 
          "mofetil", 
          "trials", 
          "mucositis", 
          "patients", 
          "transplantation", 
          "HLA", 
          "engraftment", 
          "group", 
          "donors", 
          "cyclosporine", 
          "tacrolimus", 
          "methotrexate", 
          "graft", 
          "mortality", 
          "endpoint", 
          "MRD", 
          "survival", 
          "inhibitors", 
          "study", 
          "siblings", 
          "conclusion", 
          "rate", 
          "acid", 
          "concentration", 
          "use", 
          "feasibility", 
          "alternative", 
          "results"
        ], 
        "name": "Use of mycophenolate mofetil and a calcineurin inhibitor in allogeneic hematopoietic stem-cell transplantation from HLA-matched siblings or unrelated volunteer donors: Japanese multicenter phase II trials", 
        "pagination": "485-496", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1016361753"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12185-016-2154-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27943166"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12185-016-2154-4", 
          "https://app.dimensions.ai/details/publication/pub.1016361753"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_704.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12185-016-2154-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-016-2154-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-016-2154-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-016-2154-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-016-2154-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    409 TRIPLES      21 PREDICATES      123 URIs      102 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12185-016-2154-4 schema:about N05cc199e9c504c35abce355887d32db3
    2 N0ba3105090d44c208b8f2e383bd2b834
    3 N276c38c537764e7799fde5e3c64de7e7
    4 N4572c49c29904daebbb6e2449e2df845
    5 N54e6cee5fe9246fca85f9711a0e0a38f
    6 N60ed0d8514464f4183262916d5d67701
    7 N61efd1ba27a047b5973f42009e4f12b3
    8 N67d4697abb6a463c815c63986353b557
    9 Na19f5995f4f24940adde101de21d6042
    10 Na331afd501d44b1ca64ca77df692e4ff
    11 Na51806b3c6164ea7b25e89f0e97a163b
    12 Nafd31c23f60a4d37beeecaebd0a7e48c
    13 Nb8ea5ba6575a491fba5436eac366b6b9
    14 Nbe69fc9450b64c22bc1d6591ffb4886b
    15 Ndc3c0ce21fd648d7b5a9b5513bb7293f
    16 Ne618819f19d443b485e52ff94dbe9df9
    17 Nec1c449b711c4e8ba4f377db121b17bf
    18 Nf795a7fd7204489a8ff2acc6865f5346
    19 Nfa9b27c6e0a3420b9fe99f4fad0a4e10
    20 anzsrc-for:11
    21 anzsrc-for:1102
    22 schema:author N4f0833eadb4b405b8731cf8dc0956daa
    23 schema:citation sg:pub.10.1007/s12185-008-0093-4
    24 sg:pub.10.1007/s12185-011-0805-z
    25 sg:pub.10.1007/s12185-011-0817-8
    26 sg:pub.10.1007/s12185-011-0888-6
    27 sg:pub.10.1007/s12185-012-1086-x
    28 sg:pub.10.1007/s12185-013-1449-y
    29 sg:pub.10.1038/bmt.2009.362
    30 sg:pub.10.1038/bmt.2012.244
    31 sg:pub.10.1038/sj.bmt.1704493
    32 sg:pub.10.1038/sj.bmt.1704647
    33 sg:pub.10.1038/sj.bmt.1704956
    34 sg:pub.10.1038/sj.leu.2403343
    35 sg:pub.10.1532/ijh97.05168
    36 schema:datePublished 2016-12-09
    37 schema:datePublishedReg 2016-12-09
    38 schema:description To test the feasibility of mycophenolate mofetil (MMF) for graft-versus-host disease (GVHD) prophylaxis in Japanese patients, we conducted two multicenter prospective phase II trials of allogeneic hematopoietic stem-cell transplantation (HSCT) from HLA-matched related donors (MRD group) with MMF and cyclosporine or HLA 7–8/8 allele-matched unrelated bone-marrow donors (URD group) with MMF and tacrolimus. The cumulative incidences of grade II–IV acute GVHD on day 100, which was the primary endpoint in these trials, were 45.0% (90% CI 25.8–62.5) and 25.8% (90% CI 13.9–39.5) in the MRD (n = 20) and URD (n = 31) groups, respectively. The rates of 3-year overall survival and non-relapse mortality were 80.0 and 15.0% in the MRD group and 74.2 and 6.5% in the URD group, respectively. GVHD prophylaxis with MMF may lead to a lower incidence of severe mucositis and faster neutrophil engraftment compared to that with methotrexate. A pharmacokinetics study of mycophenolic acid (MPA) showed that a relatively higher plasma concentration of MPA was associated with a lower incidence of acute GVHD. In conclusion, the results of these studies suggest that GVHD prophylaxis with MMF may be useful as an alternative in Japanese patients who may benefit from faster engraftment or less severe mucositis after allogeneic HSCT.
    39 schema:genre article
    40 schema:isAccessibleForFree false
    41 schema:isPartOf N2438188c9478402eafe98951486fc151
    42 N916799de627f45d9b2a8c225ac77af20
    43 sg:journal.1076985
    44 schema:keywords GVHD
    45 HLA
    46 II trial
    47 Japanese patients
    48 MRD
    49 MRD group
    50 URD group
    51 acid
    52 acute GVHD
    53 allogeneic hematopoietic stem cell transplantation
    54 alternative
    55 bone marrow donors
    56 calcineurin inhibitors
    57 concentration
    58 conclusion
    59 cumulative incidence
    60 cyclosporine
    61 day 100
    62 disease prophylaxis
    63 donors
    64 endpoint
    65 engraftment
    66 faster engraftment
    67 feasibility
    68 grade II
    69 graft
    70 group
    71 hematopoietic stem cell transplantation
    72 higher plasma concentrations
    73 host disease (GVHD) prophylaxis
    74 incidence
    75 inhibitors
    76 lower incidence
    77 methotrexate
    78 mofetil
    79 mortality
    80 mucositis
    81 multicenter phase II trial
    82 multicenter prospective phase II trial
    83 mycophenolate mofetil
    84 mycophenolic acid
    85 neutrophil engraftment
    86 non-relapse mortality
    87 overall survival
    88 patients
    89 pharmacokinetic study
    90 phase II trial
    91 plasma concentrations
    92 primary endpoint
    93 prophylaxis
    94 prospective phase II trial
    95 rate
    96 related donors
    97 results
    98 severe mucositis
    99 siblings
    100 stem cell transplantation
    101 study
    102 survival
    103 tacrolimus
    104 transplantation
    105 trials
    106 unrelated bone marrow donors
    107 unrelated volunteer donors
    108 use
    109 volunteer donors
    110 schema:name Use of mycophenolate mofetil and a calcineurin inhibitor in allogeneic hematopoietic stem-cell transplantation from HLA-matched siblings or unrelated volunteer donors: Japanese multicenter phase II trials
    111 schema:pagination 485-496
    112 schema:productId N063c18a6a38d4112b05948a9ab026c23
    113 N138bef8866a447759e0f8eff1c461893
    114 Neaea13ccea434dcba86430c8019914e4
    115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016361753
    116 https://doi.org/10.1007/s12185-016-2154-4
    117 schema:sdDatePublished 2022-12-01T06:35
    118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    119 schema:sdPublisher N7cbaf4c46ef24710b4b1bedd70fa488b
    120 schema:url https://doi.org/10.1007/s12185-016-2154-4
    121 sgo:license sg:explorer/license/
    122 sgo:sdDataset articles
    123 rdf:type schema:ScholarlyArticle
    124 N03808db26f2546afbddba16426656cbf rdf:first sg:person.0766701355.86
    125 rdf:rest Ne1e3b88dc82c4897bb924b604290e4bb
    126 N05cc199e9c504c35abce355887d32db3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Calcineurin Inhibitors
    128 rdf:type schema:DefinedTerm
    129 N063c18a6a38d4112b05948a9ab026c23 schema:name dimensions_id
    130 schema:value pub.1016361753
    131 rdf:type schema:PropertyValue
    132 N0ba3105090d44c208b8f2e383bd2b834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Mucositis
    134 rdf:type schema:DefinedTerm
    135 N138bef8866a447759e0f8eff1c461893 schema:name doi
    136 schema:value 10.1007/s12185-016-2154-4
    137 rdf:type schema:PropertyValue
    138 N1a8ecac5ca4244bd960f439b99d82e19 rdf:first sg:person.0577702220.98
    139 rdf:rest Ne86683e3c82e4231aa16a57a0d6a5be0
    140 N1f63746fd15a4644a818f95a0c793a17 rdf:first sg:person.015754574322.05
    141 rdf:rest N96e706a0e54343c9bb5878193c27b644
    142 N2438188c9478402eafe98951486fc151 schema:volumeNumber 105
    143 rdf:type schema:PublicationVolume
    144 N276c38c537764e7799fde5e3c64de7e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Male
    146 rdf:type schema:DefinedTerm
    147 N3b67d2fa150646ce8ffd91955d9a522e rdf:first sg:person.013316550132.06
    148 rdf:rest N90a4aece35a14f7e9fb77fd198863ab1
    149 N4572c49c29904daebbb6e2449e2df845 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Histocompatibility
    151 rdf:type schema:DefinedTerm
    152 N467a7a835f7d433e81553c986b12044f rdf:first sg:person.0625717355.49
    153 rdf:rest N3b67d2fa150646ce8ffd91955d9a522e
    154 N4f0833eadb4b405b8731cf8dc0956daa rdf:first sg:person.01324645723.81
    155 rdf:rest N9a7dbb210e5b412e9d9fcffab72c2d55
    156 N52af70c98e92496892939c71463759f4 rdf:first sg:person.01155140523.15
    157 rdf:rest N467a7a835f7d433e81553c986b12044f
    158 N52fde98ba1c440cfa17cac1dc660f869 rdf:first sg:person.01071077443.23
    159 rdf:rest N03808db26f2546afbddba16426656cbf
    160 N54e6cee5fe9246fca85f9711a0e0a38f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Graft Survival
    162 rdf:type schema:DefinedTerm
    163 N564d8bb03c5a4ed7ad2de7d27bbffcde rdf:first sg:person.01302400655.42
    164 rdf:rest Nf6a77485db104db891d01ba9ed8b9e8e
    165 N60ed0d8514464f4183262916d5d67701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Middle Aged
    167 rdf:type schema:DefinedTerm
    168 N61efd1ba27a047b5973f42009e4f12b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Graft vs Host Disease
    170 rdf:type schema:DefinedTerm
    171 N67d4697abb6a463c815c63986353b557 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Siblings
    173 rdf:type schema:DefinedTerm
    174 N7cbaf4c46ef24710b4b1bedd70fa488b schema:name Springer Nature - SN SciGraph project
    175 rdf:type schema:Organization
    176 N8a830b789df2482f8c19495cb2acf27d rdf:first sg:person.016452523632.46
    177 rdf:rest rdf:nil
    178 N90a4aece35a14f7e9fb77fd198863ab1 rdf:first sg:person.01055256533.47
    179 rdf:rest N1a8ecac5ca4244bd960f439b99d82e19
    180 N916799de627f45d9b2a8c225ac77af20 schema:issueNumber 4
    181 rdf:type schema:PublicationIssue
    182 N96e706a0e54343c9bb5878193c27b644 rdf:first sg:person.0746110262.83
    183 rdf:rest Nfd926db929d74f41980f4ee95c3d738c
    184 N9a7dbb210e5b412e9d9fcffab72c2d55 rdf:first sg:person.01014223462.98
    185 rdf:rest Nede8a2015fe24b8f81e4b66bbddcb147
    186 Na19f5995f4f24940adde101de21d6042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Aged
    188 rdf:type schema:DefinedTerm
    189 Na331afd501d44b1ca64ca77df692e4ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Female
    191 rdf:type schema:DefinedTerm
    192 Na51806b3c6164ea7b25e89f0e97a163b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Transplantation, Homologous
    194 rdf:type schema:DefinedTerm
    195 Nafd31c23f60a4d37beeecaebd0a7e48c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Humans
    197 rdf:type schema:DefinedTerm
    198 Nb8ea5ba6575a491fba5436eac366b6b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Hematopoietic Stem Cell Transplantation
    200 rdf:type schema:DefinedTerm
    201 Nbe69fc9450b64c22bc1d6591ffb4886b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Adult
    203 rdf:type schema:DefinedTerm
    204 Ndc3c0ce21fd648d7b5a9b5513bb7293f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name HLA Antigens
    206 rdf:type schema:DefinedTerm
    207 Ne1e3b88dc82c4897bb924b604290e4bb rdf:first sg:person.01171543443.41
    208 rdf:rest N1f63746fd15a4644a818f95a0c793a17
    209 Ne618819f19d443b485e52ff94dbe9df9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Japan
    211 rdf:type schema:DefinedTerm
    212 Ne86683e3c82e4231aa16a57a0d6a5be0 rdf:first sg:person.0777446051.79
    213 rdf:rest N8a830b789df2482f8c19495cb2acf27d
    214 Neaea13ccea434dcba86430c8019914e4 schema:name pubmed_id
    215 schema:value 27943166
    216 rdf:type schema:PropertyValue
    217 Nec1c449b711c4e8ba4f377db121b17bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Mycophenolic Acid
    219 rdf:type schema:DefinedTerm
    220 Nede8a2015fe24b8f81e4b66bbddcb147 rdf:first sg:person.011640722042.31
    221 rdf:rest N564d8bb03c5a4ed7ad2de7d27bbffcde
    222 Nf6a77485db104db891d01ba9ed8b9e8e rdf:first sg:person.01117233146.65
    223 rdf:rest N52fde98ba1c440cfa17cac1dc660f869
    224 Nf795a7fd7204489a8ff2acc6865f5346 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Volunteers
    226 rdf:type schema:DefinedTerm
    227 Nfa9b27c6e0a3420b9fe99f4fad0a4e10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Unrelated Donors
    229 rdf:type schema:DefinedTerm
    230 Nfd926db929d74f41980f4ee95c3d738c rdf:first sg:person.01241556073.31
    231 rdf:rest N52af70c98e92496892939c71463759f4
    232 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    233 schema:name Medical and Health Sciences
    234 rdf:type schema:DefinedTerm
    235 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    236 schema:name Cardiorespiratory Medicine and Haematology
    237 rdf:type schema:DefinedTerm
    238 sg:grant.9340323 http://pending.schema.org/fundedItem sg:pub.10.1007/s12185-016-2154-4
    239 rdf:type schema:MonetaryGrant
    240 sg:journal.1076985 schema:issn 0925-5710
    241 1865-3774
    242 schema:name International Journal of Hematology
    243 schema:publisher Springer Nature
    244 rdf:type schema:Periodical
    245 sg:person.01014223462.98 schema:affiliation grid-institutes:grid.261445.0
    246 schema:familyName Nakamae
    247 schema:givenName Hirohisa
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98
    249 rdf:type schema:Person
    250 sg:person.01055256533.47 schema:affiliation grid-institutes:grid.260338.c
    251 schema:familyName Yamamori
    252 schema:givenName Motohiro
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055256533.47
    254 rdf:type schema:Person
    255 sg:person.01071077443.23 schema:affiliation grid-institutes:grid.415538.e
    256 schema:familyName Hidaka
    257 schema:givenName Michihiro
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071077443.23
    259 rdf:type schema:Person
    260 sg:person.01117233146.65 schema:affiliation grid-institutes:grid.411102.7
    261 schema:familyName Okamura
    262 schema:givenName Atsuo
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117233146.65
    264 rdf:type schema:Person
    265 sg:person.01155140523.15 schema:affiliation grid-institutes:grid.31432.37
    266 schema:familyName Katayama
    267 schema:givenName Yoshio
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155140523.15
    269 rdf:type schema:Person
    270 sg:person.011640722042.31 schema:affiliation grid-institutes:grid.69566.3a
    271 schema:familyName Yamaguchi
    272 schema:givenName Takuhiro
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011640722042.31
    274 rdf:type schema:Person
    275 sg:person.01171543443.41 schema:affiliation grid-institutes:grid.459633.e
    276 schema:familyName Kohno
    277 schema:givenName Akio
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171543443.41
    279 rdf:type schema:Person
    280 sg:person.01241556073.31 schema:affiliation grid-institutes:grid.412857.d
    281 schema:familyName Hatanaka
    282 schema:givenName Kazuo
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241556073.31
    284 rdf:type schema:Person
    285 sg:person.01302400655.42 schema:affiliation grid-institutes:grid.272242.3
    286 schema:familyName Kurosawa
    287 schema:givenName Saiko
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302400655.42
    289 rdf:type schema:Person
    290 sg:person.01324645723.81 schema:affiliation grid-institutes:grid.261445.0
    291 schema:familyName Nakane
    292 schema:givenName Takahiko
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324645723.81
    294 rdf:type schema:Person
    295 sg:person.013316550132.06 schema:affiliation grid-institutes:grid.31432.37
    296 schema:familyName Matsui
    297 schema:givenName Toshimitsu
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013316550132.06
    299 rdf:type schema:Person
    300 sg:person.015754574322.05 schema:affiliation grid-institutes:grid.411898.d
    301 schema:familyName Saito
    302 schema:givenName Takeshi
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015754574322.05
    304 rdf:type schema:Person
    305 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
    306 schema:familyName Fukuda
    307 schema:givenName Takahiro
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
    309 rdf:type schema:Person
    310 sg:person.0577702220.98 schema:affiliation grid-institutes:grid.411234.1
    311 schema:familyName Takami
    312 schema:givenName Akiyoshi
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98
    314 rdf:type schema:Person
    315 sg:person.0625717355.49 schema:affiliation grid-institutes:grid.411102.7
    316 schema:familyName Yakushijin
    317 schema:givenName Kimikazu
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625717355.49
    319 rdf:type schema:Person
    320 sg:person.0746110262.83 schema:affiliation grid-institutes:grid.472010.0
    321 schema:familyName Aoyama
    322 schema:givenName Yasutaka
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746110262.83
    324 rdf:type schema:Person
    325 sg:person.0766701355.86 schema:affiliation grid-institutes:grid.272242.3
    326 schema:familyName Fuji
    327 schema:givenName Shigeo
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766701355.86
    329 rdf:type schema:Person
    330 sg:person.0777446051.79 schema:affiliation grid-institutes:grid.261445.0
    331 schema:familyName Hino
    332 schema:givenName Masayuki
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777446051.79
    334 rdf:type schema:Person
    335 sg:pub.10.1007/s12185-008-0093-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002235097
    336 https://doi.org/10.1007/s12185-008-0093-4
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1007/s12185-011-0805-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1003989070
    339 https://doi.org/10.1007/s12185-011-0805-z
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1007/s12185-011-0817-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027164270
    342 https://doi.org/10.1007/s12185-011-0817-8
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1007/s12185-011-0888-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049134449
    345 https://doi.org/10.1007/s12185-011-0888-6
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1007/s12185-012-1086-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049970375
    348 https://doi.org/10.1007/s12185-012-1086-x
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1007/s12185-013-1449-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1002022637
    351 https://doi.org/10.1007/s12185-013-1449-y
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/bmt.2009.362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025829761
    354 https://doi.org/10.1038/bmt.2009.362
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    357 https://doi.org/10.1038/bmt.2012.244
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/sj.bmt.1704493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017083267
    360 https://doi.org/10.1038/sj.bmt.1704493
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/sj.bmt.1704647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015331321
    363 https://doi.org/10.1038/sj.bmt.1704647
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/sj.bmt.1704956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035693959
    366 https://doi.org/10.1038/sj.bmt.1704956
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/sj.leu.2403343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034199655
    369 https://doi.org/10.1038/sj.leu.2403343
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1532/ijh97.05168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008968516
    372 https://doi.org/10.1532/ijh97.05168
    373 rdf:type schema:CreativeWork
    374 grid-institutes:grid.260338.c schema:alternateName Department of Clinical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Hyogo, Japan
    375 schema:name Department of Clinical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Hyogo, Japan
    376 rdf:type schema:Organization
    377 grid-institutes:grid.261445.0 schema:alternateName Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    378 schema:name Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    379 rdf:type schema:Organization
    380 grid-institutes:grid.272242.3 schema:alternateName Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
    381 schema:name Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
    382 rdf:type schema:Organization
    383 grid-institutes:grid.31432.37 schema:alternateName Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    384 schema:name Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    385 rdf:type schema:Organization
    386 grid-institutes:grid.411102.7 schema:alternateName Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan
    387 schema:name Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan
    388 rdf:type schema:Organization
    389 grid-institutes:grid.411234.1 schema:alternateName Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan
    390 schema:name Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan
    391 rdf:type schema:Organization
    392 grid-institutes:grid.411898.d schema:alternateName Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    393 schema:name Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    394 rdf:type schema:Organization
    395 grid-institutes:grid.412857.d schema:alternateName Department of Hematology/Oncology, Wakayama Medical University Hospital, Wakayama, Japan
    396 schema:name Department of Hematology/Oncology, Wakayama Medical University Hospital, Wakayama, Japan
    397 rdf:type schema:Organization
    398 grid-institutes:grid.415538.e schema:alternateName Department of Hematology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan
    399 schema:name Department of Hematology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan
    400 rdf:type schema:Organization
    401 grid-institutes:grid.459633.e schema:alternateName Department of Hematology and Oncology, JA Aichi Konan Kosei Hospital, Konan, Japan
    402 schema:name Department of Hematology and Oncology, JA Aichi Konan Kosei Hospital, Konan, Japan
    403 rdf:type schema:Organization
    404 grid-institutes:grid.472010.0 schema:alternateName Department of Hematology, Seichokai Fuchu Hospital, Izumi, Japan
    405 schema:name Department of Hematology, Seichokai Fuchu Hospital, Izumi, Japan
    406 rdf:type schema:Organization
    407 grid-institutes:grid.69566.3a schema:alternateName Division of Biostatistics, Tohoku University Graduate School of Medicine, Miyagi, Japan
    408 schema:name Division of Biostatistics, Tohoku University Graduate School of Medicine, Miyagi, Japan
    409 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...