Bendamustine plus rituximab for previously untreated patients with indolent B-cell non-Hodgkin lymphoma or mantle cell lymphoma: a multicenter Phase II ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11-29

AUTHORS

Michinori Ogura, Kenichi Ishizawa, Dai Maruyama, Naokuni Uike, Kiyoshi Ando, Koji Izutsu, Yasuhito Terui, Yoshitaka Imaizumi, Kunihiro Tsukasaki, Kenshi Suzuki, Tohru Izumi, Kensuke Usuki, Tomohiro Kinoshita, Masafumi Taniwaki, Nobuhiko Uoshima, Junji Suzumiya, Mitsutoshi Kurosawa, Hirokazu Nagai, Toshiki Uchida, Noriko Fukuhara, Ilseung Choi, Ken Ohmachi, Go Yamamoto, Kensei Tobinai, For the Japanese Bendamustine Lymphoma Study Group

ABSTRACT

A Phase II, multicenter clinical trial of bendamustine plus rituximab (BR) regimen was conducted in previously untreated patients with high-tumor-burden indolent B-cell non-Hodgkin lymphoma (B-NHL) and previously untreated elderly patients with mantle cell lymphoma (MCL) in Japan. Bendamustine 90 mg/m2/day on days 1 and 2, as well as rituximab 375 mg/m2 on day 1 were administered intravenously up to six cycles. The primary endpoint was the complete response (CR) rate as assessed by the International Workshop Response Criteria (1999). Sixty-nine patients (59 with indolent B-NHL and 10 with MCL) were treated. The median number of delivered cycles was six (range 1–6). The CR rates were 67.8% [95% confidence interval (CI) 54.4–79.4%] and 70.0% (95% CI 34.8–93.3%) for indolent B-NHL and MCL, respectively. Estimated progression-free survival at 30 months was 72.1% (95% CI 58.5–82.0%) in indolent B-NHL and was 67.5% (95% CI 29.1–88.2%) in MCL. Major grade 3/4 toxicities were hematologic and included lymphopenia (97%), CD4 lymphopenia (91%), neutropenia (86%), and leukopenia (83%). No treatment-related death was found. The BR regimen showed high efficacy as evidenced by the expected CR rate and durable response, as well as an acceptable safety profile for the study populations. More... »

PAGES

470-477

Journal

TITLE

International Journal of Hematology

ISSUE

4

VOLUME

105

Author Affiliations

  • Department of Hematology, Tokai Central Hospital, 4-6-2 Higashijimacho, Sohara, 504-8601, Kakamigahara, Gifu, Japan
  • Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
  • Department of Hematology, National Cancer Center Hospital, Tokyo, Japan
  • Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
  • Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan
  • Department of Hematology, Toranomon Hospital, Tokyo, Japan
  • Department of Hematology Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
  • Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
  • Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan
  • Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
  • Division of Hematology, Tochigi Cancer Center, Utsunomiya, Japan
  • Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
  • Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan
  • Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan
  • Department of Oncology/Hematology, School of Medicine, Shimane University, Izumo, Japan
  • Department of Hematology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan
  • Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
  • Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-016-2146-4

    DOI

    http://dx.doi.org/10.1007/s12185-016-2146-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053131460

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27900638


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bendamustine Hydrochloride", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Japan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukopenia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoma, B-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoma, Mantle-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neutropenia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rituximab", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Tokai Central Hospital, 4-6-2 Higashijimacho, Sohara, 504-8601, Kakamigahara, Gifu, Japan", 
              "id": "http://www.grid.ac/institutes/grid.460103.0", 
              "name": [
                "Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan", 
                "Department of Hematology, Tokai Central Hospital, 4-6-2 Higashijimacho, Sohara, 504-8601, Kakamigahara, Gifu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogura", 
            "givenName": "Michinori", 
            "id": "sg:person.01173414200.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173414200.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishizawa", 
            "givenName": "Kenichi", 
            "id": "sg:person.016152636437.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016152636437.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Cancer Center Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Hematology, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maruyama", 
            "givenName": "Dai", 
            "id": "sg:person.01340251672.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340251672.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.470350.5", 
              "name": [
                "Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uike", 
            "givenName": "Naokuni", 
            "id": "sg:person.01002213667.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002213667.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412767.1", 
              "name": [
                "Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ando", 
            "givenName": "Kiyoshi", 
            "id": "sg:person.015274442102.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015274442102.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Toranomon Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410813.f", 
              "name": [
                "Department of Hematology, Toranomon Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Izutsu", 
            "givenName": "Koji", 
            "id": "sg:person.01277263470.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277263470.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410807.a", 
              "name": [
                "Department of Hematology Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Terui", 
            "givenName": "Yasuhito", 
            "id": "sg:person.0764246107.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764246107.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411873.8", 
              "name": [
                "Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Imaizumi", 
            "givenName": "Yoshitaka", 
            "id": "sg:person.0700256565.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700256565.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsukasaki", 
            "givenName": "Kunihiro", 
            "id": "sg:person.01356462526.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356462526.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414929.3", 
              "name": [
                "Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Kenshi", 
            "id": "sg:person.014724732234.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014724732234.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Tochigi Cancer Center, Utsunomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.420115.3", 
              "name": [
                "Division of Hematology, Tochigi Cancer Center, Utsunomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Izumi", 
            "givenName": "Tohru", 
            "id": "sg:person.016006612452.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016006612452.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414992.3", 
              "name": [
                "Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Usuki", 
            "givenName": "Kensuke", 
            "id": "sg:person.0724116206.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kinoshita", 
            "givenName": "Tomohiro", 
            "id": "sg:person.0772031455.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772031455.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272458.e", 
              "name": [
                "Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Taniwaki", 
            "givenName": "Masafumi", 
            "id": "sg:person.01320436003.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320436003.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416591.e", 
              "name": [
                "Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uoshima", 
            "givenName": "Nobuhiko", 
            "id": "sg:person.0677311502.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677311502.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology/Hematology, School of Medicine, Shimane University, Izumo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411621.1", 
              "name": [
                "Department of Oncology/Hematology, School of Medicine, Shimane University, Izumo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzumiya", 
            "givenName": "Junji", 
            "id": "sg:person.01271210744.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271210744.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415270.5", 
              "name": [
                "Department of Hematology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kurosawa", 
            "givenName": "Mitsutoshi", 
            "id": "sg:person.01335503316.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335503316.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410840.9", 
              "name": [
                "Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagai", 
            "givenName": "Hirokazu", 
            "id": "sg:person.015750741112.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015750741112.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413410.3", 
              "name": [
                "Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uchida", 
            "givenName": "Toshiki", 
            "id": "sg:person.01332044324.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332044324.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukuhara", 
            "givenName": "Noriko", 
            "id": "sg:person.01347504676.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347504676.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.470350.5", 
              "name": [
                "Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Ilseung", 
            "id": "sg:person.0745256126.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745256126.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412767.1", 
              "name": [
                "Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohmachi", 
            "givenName": "Ken", 
            "id": "sg:person.01321520521.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321520521.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Toranomon Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410813.f", 
              "name": [
                "Department of Hematology, Toranomon Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamamoto", 
            "givenName": "Go", 
            "id": "sg:person.0707322147.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707322147.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Cancer Center Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Hematology, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tobinai", 
            "givenName": "Kensei", 
            "id": "sg:person.01210303461.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210303461.01"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "For the Japanese Bendamustine Lymphoma Study Group", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00277-015-2404-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017420106", 
              "https://doi.org/10.1007/s00277-015-2404-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2014.171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002037429", 
              "https://doi.org/10.1038/leu.2014.171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-016-2668-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016934551", 
              "https://doi.org/10.1007/s00277-016-2668-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2014.91", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025813325", 
              "https://doi.org/10.1038/leu.2014.91"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-11-29", 
        "datePublishedReg": "2016-11-29", 
        "description": "A Phase II, multicenter clinical trial of bendamustine plus rituximab (BR) regimen was conducted in previously untreated patients with high-tumor-burden indolent B-cell non-Hodgkin lymphoma (B-NHL) and previously untreated elderly patients with mantle cell lymphoma (MCL) in Japan. Bendamustine 90\u00a0mg/m2/day on days 1 and 2, as well as rituximab 375\u00a0mg/m2 on day 1 were administered intravenously up to six cycles. The primary endpoint was the complete response (CR) rate as assessed by the International Workshop Response Criteria (1999). Sixty-nine patients (59 with indolent B-NHL and 10 with MCL) were treated. The median number of delivered cycles was six (range 1\u20136). The CR rates were 67.8% [95% confidence interval (CI) 54.4\u201379.4%] and 70.0% (95% CI 34.8\u201393.3%) for indolent B-NHL and MCL, respectively. Estimated progression-free survival at 30\u00a0months was 72.1% (95% CI 58.5\u201382.0%) in indolent B-NHL and was 67.5% (95% CI 29.1\u201388.2%) in MCL. Major grade 3/4 toxicities were hematologic and included lymphopenia (97%), CD4 lymphopenia (91%), neutropenia (86%), and leukopenia (83%). No treatment-related death was found. The BR regimen showed high efficacy as evidenced by the expected CR rate and durable response, as well as an acceptable safety profile for the study populations.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12185-016-2146-4", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5870477", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1076985", 
            "issn": [
              "0925-5710", 
              "1865-3774"
            ], 
            "name": "International Journal of Hematology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "105"
          }
        ], 
        "keywords": [
          "mantle cell lymphoma", 
          "cell non-Hodgkin lymphoma", 
          "non-Hodgkin lymphoma", 
          "indolent B", 
          "untreated patients", 
          "CR rate", 
          "clinical trials", 
          "day 1", 
          "cell lymphoma", 
          "multicenter phase II clinical trial", 
          "International Workshop Response Criteria", 
          "Major grade 3/4 toxicities", 
          "treatment-related deaths", 
          "progression-free survival", 
          "phase II clinical trial", 
          "grade 3/4 toxicities", 
          "complete response rate", 
          "untreated elderly patients", 
          "acceptable safety profile", 
          "multicenter clinical trial", 
          "rituximab regimen", 
          "BR regimen", 
          "primary endpoint", 
          "CD4 lymphopenia", 
          "durable responses", 
          "elderly patients", 
          "safety profile", 
          "study population", 
          "median number", 
          "m2/day", 
          "response rate", 
          "patients", 
          "lymphoma", 
          "response criteria", 
          "high efficacy", 
          "phase II", 
          "regimen", 
          "lymphopenia", 
          "NHL", 
          "trials", 
          "neutropenia", 
          "leukopenia", 
          "bendamustine", 
          "months", 
          "endpoints", 
          "efficacy", 
          "death", 
          "survival", 
          "rate", 
          "days", 
          "toxicity", 
          "population", 
          "response", 
          "criteria", 
          "m2", 
          "Japan", 
          "cycle", 
          "profile", 
          "number", 
          "burden indolent B", 
          "Workshop Response Criteria", 
          "II clinical trial"
        ], 
        "name": "Bendamustine plus rituximab for previously untreated patients with indolent B-cell non-Hodgkin lymphoma or mantle cell lymphoma: a multicenter Phase II clinical trial in Japan", 
        "pagination": "470-477", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053131460"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12185-016-2146-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27900638"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12185-016-2146-4", 
          "https://app.dimensions.ai/details/publication/pub.1053131460"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_719.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12185-016-2146-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-016-2146-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-016-2146-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-016-2146-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-016-2146-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    426 TRIPLES      22 PREDICATES      108 URIs      96 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12185-016-2146-4 schema:about N081972daf9664c4a9091f50a1636cc9c
    2 N08950c0926804891a10039e6cd115bcd
    3 N2a69629ff7be499da4a8850f41299855
    4 N3148cbb4ae6a449aa1ab5e9ea3bc0a89
    5 N44efc5b93e3b45ebade0ee428cf95552
    6 N51884c6a2cca4680a0df40397be6d3a6
    7 N54fa46d5643448a5a5f4fa99559912c8
    8 N636bbbc007d94b4d86bdafc7ad00749a
    9 N99e01a20151f4425b8c45a09ad0c4830
    10 Nac43c996f68f40c39df52aa20090f778
    11 Nc9adfaac36684e72a94c557c6c5f5c6c
    12 Nd3501972f27c4063bd45ba3da49b4bdb
    13 Ne46a3ab5a6a94708a39a31c43e66db83
    14 Ne881de7e9c9a4a7eb28d274921cf8b56
    15 Nece92b3a78824f91bda6a2a66e5f28eb
    16 Nf596b2c5f29547808a8f5c3b531b00cd
    17 anzsrc-for:11
    18 anzsrc-for:1112
    19 schema:author Ncb2ae630b37a442b82d1a57f6a1fbbc7
    20 schema:citation sg:pub.10.1007/s00277-015-2404-1
    21 sg:pub.10.1007/s00277-016-2668-0
    22 sg:pub.10.1038/leu.2014.171
    23 sg:pub.10.1038/leu.2014.91
    24 schema:datePublished 2016-11-29
    25 schema:datePublishedReg 2016-11-29
    26 schema:description A Phase II, multicenter clinical trial of bendamustine plus rituximab (BR) regimen was conducted in previously untreated patients with high-tumor-burden indolent B-cell non-Hodgkin lymphoma (B-NHL) and previously untreated elderly patients with mantle cell lymphoma (MCL) in Japan. Bendamustine 90 mg/m2/day on days 1 and 2, as well as rituximab 375 mg/m2 on day 1 were administered intravenously up to six cycles. The primary endpoint was the complete response (CR) rate as assessed by the International Workshop Response Criteria (1999). Sixty-nine patients (59 with indolent B-NHL and 10 with MCL) were treated. The median number of delivered cycles was six (range 1–6). The CR rates were 67.8% [95% confidence interval (CI) 54.4–79.4%] and 70.0% (95% CI 34.8–93.3%) for indolent B-NHL and MCL, respectively. Estimated progression-free survival at 30 months was 72.1% (95% CI 58.5–82.0%) in indolent B-NHL and was 67.5% (95% CI 29.1–88.2%) in MCL. Major grade 3/4 toxicities were hematologic and included lymphopenia (97%), CD4 lymphopenia (91%), neutropenia (86%), and leukopenia (83%). No treatment-related death was found. The BR regimen showed high efficacy as evidenced by the expected CR rate and durable response, as well as an acceptable safety profile for the study populations.
    27 schema:genre article
    28 schema:inLanguage en
    29 schema:isAccessibleForFree false
    30 schema:isPartOf N4347bcdae6084e04af1bfba0b32f5d27
    31 N6c8e7eb649734be99e4eae254509ceb9
    32 sg:journal.1076985
    33 schema:keywords BR regimen
    34 CD4 lymphopenia
    35 CR rate
    36 II clinical trial
    37 International Workshop Response Criteria
    38 Japan
    39 Major grade 3/4 toxicities
    40 NHL
    41 Workshop Response Criteria
    42 acceptable safety profile
    43 bendamustine
    44 burden indolent B
    45 cell lymphoma
    46 cell non-Hodgkin lymphoma
    47 clinical trials
    48 complete response rate
    49 criteria
    50 cycle
    51 day 1
    52 days
    53 death
    54 durable responses
    55 efficacy
    56 elderly patients
    57 endpoints
    58 grade 3/4 toxicities
    59 high efficacy
    60 indolent B
    61 leukopenia
    62 lymphoma
    63 lymphopenia
    64 m2
    65 m2/day
    66 mantle cell lymphoma
    67 median number
    68 months
    69 multicenter clinical trial
    70 multicenter phase II clinical trial
    71 neutropenia
    72 non-Hodgkin lymphoma
    73 number
    74 patients
    75 phase II
    76 phase II clinical trial
    77 population
    78 primary endpoint
    79 profile
    80 progression-free survival
    81 rate
    82 regimen
    83 response
    84 response criteria
    85 response rate
    86 rituximab regimen
    87 safety profile
    88 study population
    89 survival
    90 toxicity
    91 treatment-related deaths
    92 trials
    93 untreated elderly patients
    94 untreated patients
    95 schema:name Bendamustine plus rituximab for previously untreated patients with indolent B-cell non-Hodgkin lymphoma or mantle cell lymphoma: a multicenter Phase II clinical trial in Japan
    96 schema:pagination 470-477
    97 schema:productId N0b68b02875d948da92cb7a3f23243965
    98 N309512fa84b4413ba6aa0f56c5dea021
    99 N7adfd57b74c54064862203b70e822056
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053131460
    101 https://doi.org/10.1007/s12185-016-2146-4
    102 schema:sdDatePublished 2021-11-01T18:29
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher N705341bcd4f546809dd9257fd2a1f768
    105 schema:url https://doi.org/10.1007/s12185-016-2146-4
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N081972daf9664c4a9091f50a1636cc9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Remission Induction
    111 rdf:type schema:DefinedTerm
    112 N08950c0926804891a10039e6cd115bcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Disease-Free Survival
    114 rdf:type schema:DefinedTerm
    115 N0b68b02875d948da92cb7a3f23243965 schema:name dimensions_id
    116 schema:value pub.1053131460
    117 rdf:type schema:PropertyValue
    118 N16693f10533c4e53b8e04a8713650777 rdf:first sg:person.0745256126.40
    119 rdf:rest N5625bb20c3314230a962aae960ec6a7d
    120 N2a69629ff7be499da4a8850f41299855 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Humans
    122 rdf:type schema:DefinedTerm
    123 N2b0088466c494beebe53c4e79fa00dbf rdf:first N906f03becedd4cb38e2affcc8ed4514a
    124 rdf:rest rdf:nil
    125 N309512fa84b4413ba6aa0f56c5dea021 schema:name pubmed_id
    126 schema:value 27900638
    127 rdf:type schema:PropertyValue
    128 N3148cbb4ae6a449aa1ab5e9ea3bc0a89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Rituximab
    130 rdf:type schema:DefinedTerm
    131 N31c07b785725430b9f37e997ac3c32ab rdf:first sg:person.01340251672.58
    132 rdf:rest N6530ee4e479d4a3cbb60977bfb1742c3
    133 N41e08d18dcfb47eab7589bca1e42c7c7 rdf:first sg:person.01277263470.36
    134 rdf:rest N854de389101f4662ac20914146f867ec
    135 N4347bcdae6084e04af1bfba0b32f5d27 schema:issueNumber 4
    136 rdf:type schema:PublicationIssue
    137 N44efc5b93e3b45ebade0ee428cf95552 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Aged
    139 rdf:type schema:DefinedTerm
    140 N489431587edf4a328f495121825bd37d rdf:first sg:person.016152636437.14
    141 rdf:rest N31c07b785725430b9f37e997ac3c32ab
    142 N51884c6a2cca4680a0df40397be6d3a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Neutropenia
    144 rdf:type schema:DefinedTerm
    145 N54fa46d5643448a5a5f4fa99559912c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Middle Aged
    147 rdf:type schema:DefinedTerm
    148 N5625bb20c3314230a962aae960ec6a7d rdf:first sg:person.01321520521.34
    149 rdf:rest Na08fec230ac24f268d026aa81f9e6bb7
    150 N636bbbc007d94b4d86bdafc7ad00749a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Leukopenia
    152 rdf:type schema:DefinedTerm
    153 N6530ee4e479d4a3cbb60977bfb1742c3 rdf:first sg:person.01002213667.77
    154 rdf:rest Ne7ab81e746524121a4d1d3830e1db903
    155 N671b5a728c654a6ba4b0b0345fbc16f7 rdf:first sg:person.01356462526.00
    156 rdf:rest Nb38b0c216eff478ebcf91bcb73671d41
    157 N68eb070c1b1a45178f8655165a895e0c rdf:first sg:person.01210303461.01
    158 rdf:rest N2b0088466c494beebe53c4e79fa00dbf
    159 N6c8e7eb649734be99e4eae254509ceb9 schema:volumeNumber 105
    160 rdf:type schema:PublicationVolume
    161 N705341bcd4f546809dd9257fd2a1f768 schema:name Springer Nature - SN SciGraph project
    162 rdf:type schema:Organization
    163 N7a01683898c34ad68a013ae861f90c0f rdf:first sg:person.0772031455.20
    164 rdf:rest Na41e9a42bcde4dd8be8cd87b5d1a128b
    165 N7adfd57b74c54064862203b70e822056 schema:name doi
    166 schema:value 10.1007/s12185-016-2146-4
    167 rdf:type schema:PropertyValue
    168 N8502bcfdb9a44e9498fcd4672043013f rdf:first sg:person.01335503316.60
    169 rdf:rest Na8e47ad8c5b9413d80a1083a4bde234b
    170 N854de389101f4662ac20914146f867ec rdf:first sg:person.0764246107.45
    171 rdf:rest Ndd812ff96f5d4a08bb0c60ebb5e50df9
    172 N906f03becedd4cb38e2affcc8ed4514a schema:familyName For the Japanese Bendamustine Lymphoma Study Group
    173 rdf:type schema:Person
    174 N99e01a20151f4425b8c45a09ad0c4830 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Antineoplastic Combined Chemotherapy Protocols
    176 rdf:type schema:DefinedTerm
    177 Na08fec230ac24f268d026aa81f9e6bb7 rdf:first sg:person.0707322147.05
    178 rdf:rest N68eb070c1b1a45178f8655165a895e0c
    179 Na41e9a42bcde4dd8be8cd87b5d1a128b rdf:first sg:person.01320436003.92
    180 rdf:rest Nda93f630feb74546a061a69b4cea5cda
    181 Na8e47ad8c5b9413d80a1083a4bde234b rdf:first sg:person.015750741112.65
    182 rdf:rest Nc87e3fe49856497db40c0df3e7552738
    183 Nac43c996f68f40c39df52aa20090f778 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Adult
    185 rdf:type schema:DefinedTerm
    186 Nb38b0c216eff478ebcf91bcb73671d41 rdf:first sg:person.014724732234.38
    187 rdf:rest Nf92c3248a6634878951a6c827c3b9c49
    188 Nba3bfd2dc1634300b00641c0c41ab6cb rdf:first sg:person.01347504676.50
    189 rdf:rest N16693f10533c4e53b8e04a8713650777
    190 Nc87e3fe49856497db40c0df3e7552738 rdf:first sg:person.01332044324.88
    191 rdf:rest Nba3bfd2dc1634300b00641c0c41ab6cb
    192 Nc9adfaac36684e72a94c557c6c5f5c6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Male
    194 rdf:type schema:DefinedTerm
    195 Ncb2ae630b37a442b82d1a57f6a1fbbc7 rdf:first sg:person.01173414200.21
    196 rdf:rest N489431587edf4a328f495121825bd37d
    197 Nd3501972f27c4063bd45ba3da49b4bdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Bendamustine Hydrochloride
    199 rdf:type schema:DefinedTerm
    200 Nda93f630feb74546a061a69b4cea5cda rdf:first sg:person.0677311502.47
    201 rdf:rest Ne8cf71b1886a4ed3bf7d4c95b111ccc3
    202 Ndd812ff96f5d4a08bb0c60ebb5e50df9 rdf:first sg:person.0700256565.36
    203 rdf:rest N671b5a728c654a6ba4b0b0345fbc16f7
    204 Ne46a3ab5a6a94708a39a31c43e66db83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Lymphoma, B-Cell
    206 rdf:type schema:DefinedTerm
    207 Ne7ab81e746524121a4d1d3830e1db903 rdf:first sg:person.015274442102.98
    208 rdf:rest N41e08d18dcfb47eab7589bca1e42c7c7
    209 Ne881de7e9c9a4a7eb28d274921cf8b56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Japan
    211 rdf:type schema:DefinedTerm
    212 Ne8cf71b1886a4ed3bf7d4c95b111ccc3 rdf:first sg:person.01271210744.11
    213 rdf:rest N8502bcfdb9a44e9498fcd4672043013f
    214 Nece92b3a78824f91bda6a2a66e5f28eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Female
    216 rdf:type schema:DefinedTerm
    217 Nf596b2c5f29547808a8f5c3b531b00cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Lymphoma, Mantle-Cell
    219 rdf:type schema:DefinedTerm
    220 Nf92c3248a6634878951a6c827c3b9c49 rdf:first sg:person.016006612452.12
    221 rdf:rest Nf95638adcfe544fea64cd7cf056a6846
    222 Nf95638adcfe544fea64cd7cf056a6846 rdf:first sg:person.0724116206.23
    223 rdf:rest N7a01683898c34ad68a013ae861f90c0f
    224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    225 schema:name Medical and Health Sciences
    226 rdf:type schema:DefinedTerm
    227 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    228 schema:name Oncology and Carcinogenesis
    229 rdf:type schema:DefinedTerm
    230 sg:grant.5870477 http://pending.schema.org/fundedItem sg:pub.10.1007/s12185-016-2146-4
    231 rdf:type schema:MonetaryGrant
    232 sg:journal.1076985 schema:issn 0925-5710
    233 1865-3774
    234 schema:name International Journal of Hematology
    235 schema:publisher Springer Nature
    236 rdf:type schema:Periodical
    237 sg:person.01002213667.77 schema:affiliation grid-institutes:grid.470350.5
    238 schema:familyName Uike
    239 schema:givenName Naokuni
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002213667.77
    241 rdf:type schema:Person
    242 sg:person.01173414200.21 schema:affiliation grid-institutes:grid.460103.0
    243 schema:familyName Ogura
    244 schema:givenName Michinori
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173414200.21
    246 rdf:type schema:Person
    247 sg:person.01210303461.01 schema:affiliation grid-institutes:grid.272242.3
    248 schema:familyName Tobinai
    249 schema:givenName Kensei
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210303461.01
    251 rdf:type schema:Person
    252 sg:person.01271210744.11 schema:affiliation grid-institutes:grid.411621.1
    253 schema:familyName Suzumiya
    254 schema:givenName Junji
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271210744.11
    256 rdf:type schema:Person
    257 sg:person.01277263470.36 schema:affiliation grid-institutes:grid.410813.f
    258 schema:familyName Izutsu
    259 schema:givenName Koji
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277263470.36
    261 rdf:type schema:Person
    262 sg:person.01320436003.92 schema:affiliation grid-institutes:grid.272458.e
    263 schema:familyName Taniwaki
    264 schema:givenName Masafumi
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320436003.92
    266 rdf:type schema:Person
    267 sg:person.01321520521.34 schema:affiliation grid-institutes:grid.412767.1
    268 schema:familyName Ohmachi
    269 schema:givenName Ken
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321520521.34
    271 rdf:type schema:Person
    272 sg:person.01332044324.88 schema:affiliation grid-institutes:grid.413410.3
    273 schema:familyName Uchida
    274 schema:givenName Toshiki
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332044324.88
    276 rdf:type schema:Person
    277 sg:person.01335503316.60 schema:affiliation grid-institutes:grid.415270.5
    278 schema:familyName Kurosawa
    279 schema:givenName Mitsutoshi
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335503316.60
    281 rdf:type schema:Person
    282 sg:person.01340251672.58 schema:affiliation grid-institutes:grid.272242.3
    283 schema:familyName Maruyama
    284 schema:givenName Dai
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340251672.58
    286 rdf:type schema:Person
    287 sg:person.01347504676.50 schema:affiliation grid-institutes:grid.69566.3a
    288 schema:familyName Fukuhara
    289 schema:givenName Noriko
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347504676.50
    291 rdf:type schema:Person
    292 sg:person.01356462526.00 schema:affiliation grid-institutes:grid.497282.2
    293 schema:familyName Tsukasaki
    294 schema:givenName Kunihiro
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356462526.00
    296 rdf:type schema:Person
    297 sg:person.014724732234.38 schema:affiliation grid-institutes:grid.414929.3
    298 schema:familyName Suzuki
    299 schema:givenName Kenshi
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014724732234.38
    301 rdf:type schema:Person
    302 sg:person.015274442102.98 schema:affiliation grid-institutes:grid.412767.1
    303 schema:familyName Ando
    304 schema:givenName Kiyoshi
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015274442102.98
    306 rdf:type schema:Person
    307 sg:person.015750741112.65 schema:affiliation grid-institutes:grid.410840.9
    308 schema:familyName Nagai
    309 schema:givenName Hirokazu
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015750741112.65
    311 rdf:type schema:Person
    312 sg:person.016006612452.12 schema:affiliation grid-institutes:grid.420115.3
    313 schema:familyName Izumi
    314 schema:givenName Tohru
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016006612452.12
    316 rdf:type schema:Person
    317 sg:person.016152636437.14 schema:affiliation grid-institutes:grid.69566.3a
    318 schema:familyName Ishizawa
    319 schema:givenName Kenichi
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016152636437.14
    321 rdf:type schema:Person
    322 sg:person.0677311502.47 schema:affiliation grid-institutes:grid.416591.e
    323 schema:familyName Uoshima
    324 schema:givenName Nobuhiko
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677311502.47
    326 rdf:type schema:Person
    327 sg:person.0700256565.36 schema:affiliation grid-institutes:grid.411873.8
    328 schema:familyName Imaizumi
    329 schema:givenName Yoshitaka
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700256565.36
    331 rdf:type schema:Person
    332 sg:person.0707322147.05 schema:affiliation grid-institutes:grid.410813.f
    333 schema:familyName Yamamoto
    334 schema:givenName Go
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707322147.05
    336 rdf:type schema:Person
    337 sg:person.0724116206.23 schema:affiliation grid-institutes:grid.414992.3
    338 schema:familyName Usuki
    339 schema:givenName Kensuke
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23
    341 rdf:type schema:Person
    342 sg:person.0745256126.40 schema:affiliation grid-institutes:grid.470350.5
    343 schema:familyName Choi
    344 schema:givenName Ilseung
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745256126.40
    346 rdf:type schema:Person
    347 sg:person.0764246107.45 schema:affiliation grid-institutes:grid.410807.a
    348 schema:familyName Terui
    349 schema:givenName Yasuhito
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764246107.45
    351 rdf:type schema:Person
    352 sg:person.0772031455.20 schema:affiliation grid-institutes:grid.410800.d
    353 schema:familyName Kinoshita
    354 schema:givenName Tomohiro
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772031455.20
    356 rdf:type schema:Person
    357 sg:pub.10.1007/s00277-015-2404-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017420106
    358 https://doi.org/10.1007/s00277-015-2404-1
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1007/s00277-016-2668-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016934551
    361 https://doi.org/10.1007/s00277-016-2668-0
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/leu.2014.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002037429
    364 https://doi.org/10.1038/leu.2014.171
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/leu.2014.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025813325
    367 https://doi.org/10.1038/leu.2014.91
    368 rdf:type schema:CreativeWork
    369 grid-institutes:grid.272242.3 schema:alternateName Department of Hematology, National Cancer Center Hospital, Tokyo, Japan
    370 schema:name Department of Hematology, National Cancer Center Hospital, Tokyo, Japan
    371 rdf:type schema:Organization
    372 grid-institutes:grid.272458.e schema:alternateName Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    373 schema:name Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    374 rdf:type schema:Organization
    375 grid-institutes:grid.410800.d schema:alternateName Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan
    376 schema:name Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan
    377 rdf:type schema:Organization
    378 grid-institutes:grid.410807.a schema:alternateName Department of Hematology Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
    379 schema:name Department of Hematology Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
    380 rdf:type schema:Organization
    381 grid-institutes:grid.410813.f schema:alternateName Department of Hematology, Toranomon Hospital, Tokyo, Japan
    382 schema:name Department of Hematology, Toranomon Hospital, Tokyo, Japan
    383 rdf:type schema:Organization
    384 grid-institutes:grid.410840.9 schema:alternateName Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    385 schema:name Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    386 rdf:type schema:Organization
    387 grid-institutes:grid.411621.1 schema:alternateName Department of Oncology/Hematology, School of Medicine, Shimane University, Izumo, Japan
    388 schema:name Department of Oncology/Hematology, School of Medicine, Shimane University, Izumo, Japan
    389 rdf:type schema:Organization
    390 grid-institutes:grid.411873.8 schema:alternateName Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
    391 schema:name Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
    392 rdf:type schema:Organization
    393 grid-institutes:grid.412767.1 schema:alternateName Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan
    394 schema:name Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan
    395 rdf:type schema:Organization
    396 grid-institutes:grid.413410.3 schema:alternateName Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    397 schema:name Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    398 rdf:type schema:Organization
    399 grid-institutes:grid.414929.3 schema:alternateName Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
    400 schema:name Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
    401 rdf:type schema:Organization
    402 grid-institutes:grid.414992.3 schema:alternateName Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
    403 schema:name Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
    404 rdf:type schema:Organization
    405 grid-institutes:grid.415270.5 schema:alternateName Department of Hematology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan
    406 schema:name Department of Hematology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan
    407 rdf:type schema:Organization
    408 grid-institutes:grid.416591.e schema:alternateName Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan
    409 schema:name Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan
    410 rdf:type schema:Organization
    411 grid-institutes:grid.420115.3 schema:alternateName Division of Hematology, Tochigi Cancer Center, Utsunomiya, Japan
    412 schema:name Division of Hematology, Tochigi Cancer Center, Utsunomiya, Japan
    413 rdf:type schema:Organization
    414 grid-institutes:grid.460103.0 schema:alternateName Department of Hematology, Tokai Central Hospital, 4-6-2 Higashijimacho, Sohara, 504-8601, Kakamigahara, Gifu, Japan
    415 schema:name Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    416 Department of Hematology, Tokai Central Hospital, 4-6-2 Higashijimacho, Sohara, 504-8601, Kakamigahara, Gifu, Japan
    417 rdf:type schema:Organization
    418 grid-institutes:grid.470350.5 schema:alternateName Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
    419 schema:name Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
    420 rdf:type schema:Organization
    421 grid-institutes:grid.497282.2 schema:alternateName Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan
    422 schema:name Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan
    423 rdf:type schema:Organization
    424 grid-institutes:grid.69566.3a schema:alternateName Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    425 schema:name Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    426 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...