Comparison of prothrombin time tests used in the monitoring of edoxaban and their evaluation as indicators of the reversal effect View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-03-16

AUTHORS

Toshiaki Iba, Mari Emmi, Makoto Hiki, Masataka Nagayama, Koichiro Aihara, Yoko Tabe, Maiko Yuri, Akimichi Ohsaka

ABSTRACT

Clinical demand for the prompt assessment of the activity of direct-acting factor Xa inhibitors in the emergency care setting is increasing. In the present study, we examined whether prothrombin time (PT) tests can serve as a clinically useful indicator of anti-factor Xa activity. In the first series, the in vitro effect of edoxaban on PT was evaluated by spiking human plasma with edoxaban and measuring PT using three different commercial PT tests. In the second series, the reversal effect of prothrombin complex concentrates (PCC) and activated PCC (aPCC) in edoxaban-spiked plasma was evaluated. In the third series, PT of plasma samples from patients administered either 15 or 30 mg/day of edoxaban was assessed, and the results were compared with edoxaban concentrations determined by a calibrated anti-factor Xa activity assay. The spike test revealed that all PT reagents positively correlated with edoxaban. The sensitivity to edoxaban varied among the three reagents and Triniclot® Excel S showed the best performance. Prolonged PT by edoxaban was reversed by PCC and aPCC in a dose-dependent manner; however, complete reversal was not achieved. Positive correlation between anti-factor Xa activity and PT was shown in the clinical samples at the edoxaban range from 0 to >300 ng/mL. More... »

PAGES

665-672

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-016-1975-5

DOI

http://dx.doi.org/10.1007/s12185-016-1975-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013360176

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26984594


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