Prognostic value of pretransplant serum C-reactive protein in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-01-20

AUTHORS

Wataru Yamamoto, Eriko Fujii, Kenji Matsumoto, Eri Yamamoto, Jun Aoki, Masatsugu Tanaka, Yoshiaki Ishigatsubo, Heiwa Kanamori

ABSTRACT

The impact of pre-transplant serum C-reactive protein (CRP) level on the outcome of reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC allo-SCT) is unclear. This study retrospectively investigated 78 patients who underwent RIC allo-SCT between 2005 and 2013. The conditioning regimen consisted of fludarabine and melphalan with/without total body irradiation. The 3-year overall survival of high CRP (43.6 % of all patients) patients was significantly worse than that of normal CRP patients in whom CRP was ≤0.3 mg/dl (26.7 vs. 74.1 %, P < 0.001). Both the CRP level before transplantation and disease risk status were independent prognostic factors for overall survival by multivariate analysis. CRP was not a significant predictor of NRM by multivariate analysis (hazard ratio 3.2, 95 % confidence interval 0.8–13.1, P = 0.100). These results suggest that measuring the CRP level before transplantation can be useful to predicting the outcome of RIC allo-SCT. More... »

PAGES

444-452

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-016-1941-2

DOI

http://dx.doi.org/10.1007/s12185-016-1941-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044949634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26791379


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