A comparison of tacrolimus and cyclosporine combined with methotrexate for graft-versus-host disease prophylaxis, stratified by stem cell source: a retrospective ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-01-22

AUTHORS

Rika Sakai, Masataka Taguri, Kumi Oshima, Takehiko Mori, Hiroatsu Ago, Souichi Adachi, Satoshi Morita, Shuichi Taniguchi, Takahiro Fukuda, Kazuteru Ohashi, Tetsuya Eto, Koichi Miyamura, Koji Iwato, Naoki Kobayashi, Heiwa Kanamori, Yasuo Morishima, Tokiko Nagamura-Inoue, Hisashi Sakamaki, Yoshiko Atsuta, Makoto Murata

ABSTRACT

This nationwide, retrospective study compared the efficacy of cyclosporine and tacrolimus with methotrexate (CsA/MTX and TAC/MTX) for acute graft-versus-host disease (aGVHD) prevention and transplant-related outcomes. Data were obtained from the Transplant Registry Unified Management Program of the Japan Society for Hematopoietic Cell Transplantation for ≥16-year-old leukemia patients who received CsA/MTX or TAC/MTX after bone marrow transplantation and peripheral blood stem cell transplantation from serological HLA-matched related donors (MRD), HLA 8/8 allele-matched, or one allele-mismatched unrelated bone marrow (UBM), or 0–2 antigen-mismatched unrelated cord blood (UCB) transplantation between January 2005 and December 2009. Separate analyses were performed for each cohort. Adjusted multivariate analyses indicated that in the MRD (n = 1524) and the UBM (n = 1466) cohorts, TAC/MTX significantly reduced grade II–IV aGVHD risk (HR 0.58, P = 0.006 and HR 0.77, P = 0.015, respectively) without affecting the other transplant-related outcomes. In the UCB cohort (n = 925), TAC/MTX significantly reduced the risk of non-relapse mortality (HR 0.63, P = 0.027) and chronic GVHD (HR 0.60, P = 0.02) without significant effects on grade II–IV aGVHD (HR 0.83, P = 0.21). Our results may provide the most up-to-date data regarding GVHD prevention in Japan. More... »

PAGES

322-333

References to SciGraph publications

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  • Journal

    TITLE

    International Journal of Hematology

    ISSUE

    3

    VOLUME

    103

    Author Affiliations

  • Department of Medical Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-0815, Yokohama, Japan
  • Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
  • Division of Hematology and Oncology, St. Luke International Hospital, Tokyo, Japan
  • Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
  • Division of Hematology and Oncology, Shimane Prefectural Central Hospital, Matsue, Japan
  • Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Department of Hematology, Toranomon Hospital, Tokyo, Japan
  • Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Division of Hematology, Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
  • Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Department of Hematology, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan
  • Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
  • Department of Cell Processing and Transfusion, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Department of Hematopoietic Stem Cell Transplantation Data Management and Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-016-1939-9

    DOI

    http://dx.doi.org/10.1007/s12185-016-1939-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017712929

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26800676


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