A new diagnostic kit, ODK-1201, for the quantitation of low major BCR-ABL mRNA level in chronic myeloid leukemia: correlation of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-07-04

AUTHORS

Hirohisa Nakamae, Chikashi Yoshida, Yasuhiko Miyata, Michihiro Hidaka, Naokuni Uike, Daisuke Koga, Takayuki Sogabe, Itaru Matsumura, Yuzuru Kanakura, Tomoki Naoe

ABSTRACT

The current first-line therapy of chronic myeloid leukemia (CML) is based on tyrosine kinase inhibitors. Diagnostic kits that are capable of identifying at least a 4.5 log reduction in the international scale % BCR-ABL/ABL (IS % BCR-ABL/ABL) are needed for use in the clinical evaluation of deeper molecular response to treatment and to determine the timing of dose selection or treatment interruption during the course of treatment. In this study, we evaluated the performance of a new diagnostic kit, ODK-1201, designed to be capable of performing reverse transcription and quantitative PCR in a single tube for the quantitation of major BCR-ABL mRNA. The kit demonstrated excellent assay performance (limit of detection 0.0007 %) and a broader detection range of BCR-ABL mRNA in peripheral blood compared to a commercially available kit for CML (Amp-CML). ODK-1201 was also shown to be as sensitive as Ipsogen and Molecular MD kits in the same assay. Results obtained in this study indicate evidences that ODK-1201 was capable of identifying at least a 4.5 log reduction in the IS % BCR-ABL/ABL. More... »

PAGES

304-311

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-015-1826-9

DOI

http://dx.doi.org/10.1007/s12185-015-1826-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023749476

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26141653


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