Successful pregnancy and delivery via in vitro fertilization with cryopreserved and thawed embryo transfer in an acute myeloid leukemia patient ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11-28

AUTHORS

Yuki Nakajima, Hideyuki Kuwabara, Kumiko Kishimoto, Ayumi Numata, Kenji Motohashi, Takayoshi Tachibana, Masatsugu Tanaka, Naoki Yamashita, Yoshiaki Ishigatsubo, Shin Fujisawa

ABSTRACT

As the number of young long-term survivors of hematopoietic stem cell transplantation (HSCT) for acute leukemia continues to increase, post-transplant infertility is becoming a significant concern. HSCT, particularly with cyclophosphamide and total body irradiation conditioning, is known to cause secondary premature ovarian failure, resulting in infertility. To preserve post-transplant fertility, several methods have been proposed, including in vitro fertilization (IVF) with embryo cryopreservation. Due to the aggressiveness of acute leukemia, however, patients have little chance to undergo egg harvesting and IVF before they must begin receiving chemotherapy. To the best of our knowledge, there have been no detailed reports of successful pregnancy after HSCT using IVF with embryo cryopreservation and transfer in a patient with acute myeloid leukemia. Here, we report the case of a 42-year-old woman with acute myeloid leukemia who became pregnant 2 years and 2 months after allogeneic bone marrow transplantation via IVF-embryo transfer with an egg collected after induction therapy and delivered a full-term healthy infant. More... »

PAGES

417-420

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-014-1709-5

DOI

http://dx.doi.org/10.1007/s12185-014-1709-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036600692

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25430084


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