Effect of levofloxacin prophylaxis for prevention of severe infections in multiple myeloma patients receiving bortezomib-containing regimens View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11

AUTHORS

Sung-Hoon Jung, Seung-Ji Kang, Hee-Chang Jang, Jae-Sook Ahn, Deok-Hwan Yang, Seung-Shin Lee, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, Je-Jung Lee

ABSTRACT

Fluoroquinolone is recommended as a prophylactic antibiotic for high-risk patients with profound neutropenia. We previously reported that multiple myeloma (MM) patients who received bortezomib-based regimens were at higher risk of severe infections (30.9%) associated with lymphocytopenia. In the study, we evaluated whether severe infectious complications can be prevented by prophylactic administration of oral levofloxacin in MM patients treated with bortezomib-based regimens. A total of 80 patients received oral levofloxacin 500 mg daily during the median four cycles of treatment. The prophylactic group (n = 80) with levofloxacin showed significantly decreased severe infections compared to a historical control group (n = 139) without levofloxacin prophylaxis during treatment of bortezomib-based regimens (17.5 vs. 30.9%, P = 0.037). In the prophylactic group, two patients (2.5%) died of pneumonia and septic shock. Four patients (5%) stopped levofloxacin due to side effects that consisted of gastrointestinal discomfort (2.5%), itching sense (1.25%), and QTc prolongation (1.25%). In conclusion, prophylaxis with levofloxacin may be effective in the prevention of severe infection in MM patients receiving bortezomib-based regimens. A prospective randomized study is needed to test the prophylactic effect of levofloxacin in MM patients treated with bortezomib-based regimens. More... »

PAGES

473-477

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-014-1672-1

DOI

http://dx.doi.org/10.1007/s12185-014-1672-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051503742

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25212681


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-014-1672-1'

RDF/XML is a standard XML format for linked data.

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