Allogeneic hematopoietic cell transplantation for acute myeloid leukemia during first complete remission: a clinical perspective View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09-12

AUTHORS

Masamitsu Yanada

ABSTRACT

Allogeneic hematopoietic cell transplantation (HCT) is the most potent therapy for preventing relapse of acute myeloid leukemia (AML). Although its efficacy is compromised by a high risk of treatment-related morbidity and mortality, an accumulating body of evidence has led to the general recommendation favoring allogeneic HCT from a matched sibling donor during first complete remission (CR1) for younger patients with cytogenetically intermediate- or high-risk AML. Over the past few decades, this field has seen a great many advancements. The indications for allogeneic HCT have been refined by taking into account the molecular profiles of leukemic cells and the degree of comorbidities. The introduction of high-resolution human leukocyte antigen-typing technology and advances in immunosuppressive therapy and supportive care measures have improved outcomes in alternative donor transplantation, while the parallel growth of unrelated donor registries and greater use of umbilical cord blood and haploidentical donors have considerably improved the chance of finding an alternative donor. The development of reduced-intensity and non-myeloablative conditioning has made it possible to receive allogeneic HCT for patients who might once have been considered ineligible due to advanced age or comorbidities. Thanks to these advances, the role of allogeneic HCT during CR1 has become progressively more important in the treatment of AML. More... »

PAGES

243-254

References to SciGraph publications

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  • 2011-08-29. Intravenous compared with oral busulfan as preparation for allogeneic hematopoietic progenitor cell transplantation for AML and MDS in BONE MARROW TRANSPLANTATION
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  • 2012-09-03. Effect of related donor availability on outcome of AML in the context of related and unrelated hematopoietic cell transplantation in BONE MARROW TRANSPLANTATION
  • 2005-09-29. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT) in LEUKEMIA
  • 2004-01-12. Bone marrow transplantation from partially HLA-mismatched family donors for acute leukemia: single-center experience of 201 patients in BONE MARROW TRANSPLANTATION
  • 2005-04-21. The role of reduced intensity conditioning allogeneic stem cell transplantation in patients with acute myeloid leukemia: a donor vs no donor comparison in LEUKEMIA
  • 2012-12-03. Comparison of conditioning regimens of various intensities for allogeneic hematopoietic SCT using HLA-identical sibling donors in AML and MDS with <10% BM blasts: a report from EBMT in BONE MARROW TRANSPLANTATION
  • 2009-01-08. Early related or unrelated haematopoietic cell transplantation results in higher overall survival and leukaemia-free survival compared with conventional chemotherapy in high-risk acute myeloid leukaemia patients in first complete remission in LEUKEMIA
  • 2012-01-13. Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association in LEUKEMIA
  • 2010-01-09. Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia: results of the JALSG AML97 study in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2013-11-18. A prospective registration study to determine feasibility of hematopoietic SCT in adults with acute leukemia: planning, expectations and reality in BONE MARROW TRANSPLANTATION
  • 2010-05-20. Comparison of matched unrelated and matched related donor myeloablative hematopoietic cell transplantation for adults with acute myeloid leukemia in first remission in LEUKEMIA
  • 2011-03-28. Similar outcomes using myeloablative vs reduced-intensity allogeneic transplant preparative regimens for AML or MDS in BONE MARROW TRANSPLANTATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-014-1657-0

    DOI

    http://dx.doi.org/10.1007/s12185-014-1657-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031936200

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25212675


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