Limited value of the international staging system for predicting long-term outcome of transplant-ineligible, newly diagnosed, symptomatic multiple myeloma in the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04

AUTHORS

Junya Kuroda, Yuji Shimura, Kensuke Ohta, Hirokazu Tanaka, Hirohiko Shibayama, Satoru Kosugi, Shinichi Fuchida, Masayuki Kobayashi, Hitomi Kaneko, Nobuhiko Uoshima, Kazuyoshi Ishii, Shosaku Nomura, Masafumi Taniwaki, Akifumi Takaori-Kondo, Chihiro Shimazaki, Mitsuru Tsudo, Masayuki Hino, Itaru Matsumura, Yuzuru Kanakura, Kansai Myeloma Forum Investigators

ABSTRACT

We retrospectively investigated clinical outcomes and prognostic factors of 131 patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM) who received melphalan and prednisolone (MP) as first-line therapy from 2006 to 2013. Eighty-one patients received salvage therapies incorporating bortezomib, lenalidomide, and/or thalidomide. The overall response rate to MP was 54.2 %, including 9.2 % of better than very good partial response. With a median follow-up period of 30.2 months, median overall survival (OS) and median time to next treatment (TNT) were 54.4 and 19.0 months, respectively. Univariate analysis revealed that performance status and serum calcium level significantly associated with both OS and TNT, and multivariate analysis revealed that the higher serum calcium level had a significantly unfavorable impact on OS and TNT. Importantly, staging informed by the international staging system (ISS) was not predictive for OS or TNT in the analyzed cohort. Our study revealed that, in the context of first-line MP therapy for NDMM, the salvage therapy incorporating novel agents produced a survival period of >30 months after the initiation of second-line therapy, suggesting that the predictive value of ISS for OS and TNT may be limited in the era of novel agents. More... »

PAGES

441-449

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-014-1539-5

DOI

http://dx.doi.org/10.1007/s12185-014-1539-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009326181

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24584872


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