Long-term outcome of immunosuppressive therapy for Japanese patients with lower-risk myelodysplastic syndromes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Tomoko Hata, Hideki Tsushima, Maki Baba, Yoshitaka Imaizumi, Jun Taguchi, Daisuke Imanishi, Kazuhiro Nagai, Masao Tomonaga, Yasushi Miyazaki

ABSTRACT

To investigate the long-term usefulness of immunosuppressive therapy (IST) for Japanese patients with lower-risk myelodysplastic syndromes, we retrospectively analyzed 29 MDS patients who were treated with cyclosporine A alone or with anti-thymocyte globulin at a single institute in Japan. A total of 58.6 % of patients showed hematological response to IST. Overall survival of all patients was 74.5 % at 5 years and 48.3 % at 10 years. The major adverse event was the elevation of creatinine level (grade 1 and 2). Eleven patients were still on IST at the time of analysis with, at least, some clinical benefits. Pneumonia was the most frequent cause of death (eight of 12 deaths), followed by bleeding (three of 12); most of the patients who died were non-responders. The presence of paroxysmal nocturnal hemoglobinuria-type cells was significantly associated with both response to IST and long-term survival by univariate analysis. The 10-year overall survival of responders (72.2 %) was significantly superior to that of non-responders (15.6 %, P < 0.0001). These results suggest that IST using cyclosporine A provides long-term benefit for Japanese patients with lower-risk MDS. More... »

PAGES

687-693

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-013-1468-8

DOI

http://dx.doi.org/10.1007/s12185-013-1468-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029754650

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24254637


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