Successful treatment of POEMS syndrome with bortezomib and dexamethasone, combined with radiotherapy, and followed by autologous stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-10-29

AUTHORS

Yoshimi Ishii, Etsuko Yamazaki, Yasufumi Ishiyama, Eri Yamamoto, Yukako Hattori, Maki Hagihara, Naoto Tomita, Yoshiaki Ishigatsubo

ABSTRACT

POEMS syndrome is a monoclonal plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. High-dose therapy (HDT) and autologous stem cell transplantation (ASCT) are an effective therapy, but optimal treatment options are still under debate. Bortezomib is an important agent for the treatment of patients with multiple myeloma and has recently been reported as efficacious in the treatment of patients with POEMS syndrome. We present a case of POEMS syndrome in a 33-year-old woman, who was successfully treated with BorDex (bortezomib and dexamethasone) combined with radiotherapy, and followed by ASCT. She was diagnosed with POEMS syndrome with a localized plasmacytoma of bone 5 months after her initial symptoms of heart failure. Her Eastern Cooperative Oncology Group (ECOG) performance status was 4. She was first administered BorDex therapy, which was subsequently combined with radiotherapy. Her general condition including heart failure dramatically improved after four cycles of BorDex therapy and radiation, resulting in partial response. After chemoradiotherapy, HDT and ASCT were performed. After treatment, she was able to walk unassisted and her plasma endothelial growth factor (VEGF) level decreased. She did not experience neurotoxicity induced by bortezomib. Bortezomib was well tolerated and we suggest that BorDex therapy followed by HDT and ASCT may be an effective therapy for POEMS syndrome. More... »

PAGES

723-728

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-013-1456-z

DOI

http://dx.doi.org/10.1007/s12185-013-1456-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007660788

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24166587


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