Polymorphisms of ERCC1 genotype associated with response to imatinib therapy in chronic phase chronic myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09

AUTHORS

Jee Hyun Kong, Yeung-Chul Mun, Seonwoo Kim, Hang Seok Choi, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, Joon Ho Moon, Sang Kyun Sohn, Sung-Hyun Kim, Chul Won Jung, Dong Hwan (Dennis) Kim

ABSTRACT

DNA repair machinery may contribute to the mechanism of the action in imatinib. We examined the association between the single nucleotide polymorphism (SNP) markers involved in the DNA repair enzyme pathway (ERCC1/2/4/5, XRCC1/2/4/5) and the clinical outcomes following an imatinib therapy in chronic phase chronic myeloid leukemia (CML) patients. A total of 169 Korean patients were included. Of the 19 SNPs from these patients, those with the TT genotype of ERCC1 (rs11615) showed a higher probability of achieving major cytogenetic response [P = 0.002, HR 5.14 (95 % CI 1.83-14.43)], complete cytogenetic response [P = 0.012, HR 3.47 (95 % CI 1.31-9.17)], and major molecular response [P = 0.001, HR 5.71 (95 % CI 2.13-15.30)] than those with CC or CT genotypes. This suggests that SNP markers on ERCC1 may predict the response to imatinib therapy, which proposes the potential involvement of the DNA repair machinery in the mechanism of imatinib action in chronic phase CML. More... »

PAGES

327-333

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-012-1142-6

DOI

http://dx.doi.org/10.1007/s12185-012-1142-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006239013

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22821389


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