Characterization of chronic idiopathic thrombocytopenic purpura in Japanese children: a retrospective multi-center study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03

AUTHORS

Masaru Kubota, Souichi Adachi, Ikuya Usami, Masayuki Okada, Toshiyuki Kitoh, Mitsutaka Shiota, Yoshihiro Taniguchi, Akihiko Tanizawa, Mitsuhiko Nanbu, Keigo Hamahata, Hisanori Fujino, Kousaku Matsubara, Yoshihiro Wakazono, Tatsutoshi Nakahata

ABSTRACT

The objectives of this study are to clarify (1) the difference in demographic and clinical variables at initial presentation between acute and chronic idiopathic thrombocytopenic purpura (ITP), and (2) the prognostic factors of patients with chronic ITP. We conducted a retrospective analysis of 247 children with newly diagnosed ITP between April 1991 and March 2006 who visited one of the 12 hospitals belonging to the Kyoto University Pediatric Hematologic Study Group. 180 and 67 cases were classified as the acute type and as the chronic type, respectively. Older age, higher initial platelet count, positive medical history or concomitant medical diagnosis, the absence of preceding infection or vaccination, and the absence of an increase in immunoglobulin were risk factors for the chronicity. The prognostic factors in chronic ITP were evaluated in 53 patients after excluding patients receiving splenectomy or having insufficient follow-up data. The overall time required for 50% resolution in patients with chronic ITP was approximately 5.6 years. Age at presentation of less than 3 years and higher platelet counts at the time of chronic ITP diagnosis were good prognostic factors. On the other hand, gender, initial platelet counts, and preceding infection or vaccination were not associated with the prognosis. More... »

PAGES

252-257

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-009-0484-1

DOI

http://dx.doi.org/10.1007/s12185-009-0484-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053626344

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20049564


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