Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-01

AUTHORS

Yasuyoshi Morita, Akihisa Kanamaru, Yasushi Miyazaki, Daisuke Imanishi, Fumiharu Yagasaki, Mitsune Tanimoto, Kazutaka Kuriyama, Toru Kobayashi, Shion Imoto, Kazunori Ohnishi, Tomoki Naoe, Ryuzo Ohno

ABSTRACT

A total of 120 patients with high-risk myelodysplastic syndrome (MDS) and AML progressed from MDS (MDS-AML) were registered in a randomized controlled study of the Japan Adult Leukemia Study Group (JALSG). Untreated adult patients with high-risk MDS and MDS-AML were randomly assigned to receive either idarubicin and cytosine arabinoside (IDR/Ara-C) (Group A) or low-dose cytosine arabinoside and aclarubicin (CA) (Group B). The remission rates were 64.7% for Group A (33 of 51 evaluable cases) and 43.9% for Group B (29 out of 66 evaluable cases). The 2-year overall survival rates and disease-free survival rates were 28.1 and 26.0% for Group A, and 32.1 and 24.8% for Group B, respectively. The duration of CR was 320.6 days for Group A and 378.7 days for Group B. There were 15 patients who lived longer than 1,000 days after diagnosis: 6 and 9 patients in Groups A and B, respectively. However, among patients enrolled in this trial, intensive chemotherapy did not produce better survival than low-dose chemotherapy. In conclusion, it is necessary to introduce the first line therapy excluding the chemotherapy that can prolong survival in patients with high-risk MDS and MDS-AML. More... »

PAGES

97-103

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-009-0473-4

DOI

http://dx.doi.org/10.1007/s12185-009-0473-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013341559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20047095


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