Human invariant natural killer T cells: implications for immunotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

Tsuyoshi Takahashi, Mineo Kurokawa

ABSTRACT

Human invariant natural killer T cells are a unique lymphocyte population that have an invariant T-cell receptor and recognize glycolipids instead of peptides in the restriction of CD1d molecules. These natural killer T cells play important roles in anti-tumor immunity, transplantation immunity, allergy, autoimmunity and microbial immunity. Since human natural killer T cells show high-level biological activity such as cytokine production, an anti-tumor effect and regulatory T-cell control, they may be a useful tool in immune-cell therapy. In this review, we summarize the immune responses mediated by human natural killer T cells, especially in tumor and transplantation immunity, and discuss their potential in clinical applications. More... »

PAGES

137-142

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-009-0379-1

    DOI

    http://dx.doi.org/10.1007/s12185-009-0379-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036838303

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19639273


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