Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01-20

AUTHORS

Wolf C. Prall, Akos Czibere, Franck Grall, Dimitrios Spentzos, Ulrich Steidl, Aristoteles Achilles Nikolaus Giagounidis, Andrea Kuendgen, Hasan Otu, Astrid Rong, Towia A. Libermann, Ulrich Germing, Norbert Gattermann, Rainer Haas, Manuel Aivado

ABSTRACT

One feature of the molecular pathology of myelodysplastic syndromes (MDS) is aberrant gene expression. Such aberrations may be related to patient survival, and may indicate to novel diagnostic and therapeutic targets. Therefore, we aimed at identifying aberrant gene expression that is associated with MDS and patient survival. Bone marrow-derived CD34+ hematopoietic progenitor cells from six healthy persons and 16 patients with MDS were analyzed on cDNA macroarrays comprising 1,185 genes. Thereafter, our patients were followed-up for 54 months. We found differential expression of genes that were hitherto unrecognized in the context of MDS. Differential expression of 10 genes was confirmed by quantitative real-time RT-PCR. Hierarchical cluster analysis facilitated the separation of CD34+ cells of normal donors from patients with MDS. More importantly, it also distinguished MDS-patients with short and long survival. Scrutinizing our cDNA macroarray data for genes that are associated with short survival, we found, among others, increased expression of six different genes that encode the proteasome subunits. On the other hand, the most differentially down-regulated gene was IEX-1, which encodes an anti-apoptotic protein. We confirmed its decreased expression on RNA and protein level in an independent validation set of patient samples. The presented data broadens our notion about the molecular pathology of MDS and may lend itself to better identify patients with short survival. Furthermore, our findings may help to define new molecular targets for drug development and therapeutic approaches for patients with poor prognosis. More... »

PAGES

173-187

References to SciGraph publications

  • 1997-12-01. Overexpression of tumor necrosis factor (TNF)-α and interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes in LEUKEMIA
  • 2004-01-22. Differentially expressed genes in adult familial myelodysplastic syndromes in LEUKEMIA
  • 2005-09-29. Refinement of the international prognostic scoring system (IPSS) by including LDH as an additional prognostic variable to improve risk assessment in patients with primary myelodysplastic syndromes (MDS) in LEUKEMIA
  • 2001-12-03. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia in NATURE GENETICS
  • 2003-07-29. Opportunities for Trisenox® (arsenic trioxide) in the treatment of myelodysplastic syndromes in LEUKEMIA
  • 2006-04-13. The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow in LEUKEMIA
  • 2004-08-12. The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells in LEUKEMIA
  • 1995-07. Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells in NATURE MEDICINE
  • 2006-02-09. High frequency of several PIG-A mutations in patients with aplastic anemia and myelodysplastic syndrome in LEUKEMIA
  • 2003-02-01. The emergence of a C/EBPα mutation in the clonal evolution of MDS towards secondary AML in LEUKEMIA
  • 2005-12-08. Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients in LEUKEMIA
  • 2002-10-02. Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-κB/rel complexes in ONCOGENE
  • 2006-02-09. Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations in LEUKEMIA
  • 1985-06-01. Molecular characterization and expression of the gene encoding human erythroid-potentiating activity in NATURE
  • 1990-08. Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data in BRITISH JOURNAL OF CANCER
  • 2001-06. Computational analysis of microarray data in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-008-0242-9

    DOI

    http://dx.doi.org/10.1007/s12185-008-0242-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011795347

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19152102


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, CD34", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis Regulatory Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myelodysplastic Syndromes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteasome Endopeptidase Complex", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University, Nussbaumstra\u00dfe 20, 80336, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
                "Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University, Nussbaumstra\u00dfe 20, 80336, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prall", 
            "givenName": "Wolf C.", 
            "id": "sg:person.01360642667.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360642667.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239395.7", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
                "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Czibere", 
            "givenName": "Akos", 
            "id": "sg:person.01032642115.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032642115.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239395.7", 
              "name": [
                "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grall", 
            "givenName": "Franck", 
            "id": "sg:person.0734407304.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734407304.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239395.7", 
              "name": [
                "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Spentzos", 
            "givenName": "Dimitrios", 
            "id": "sg:person.0643726164.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643726164.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cell Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.251993.5", 
              "name": [
                "Department of Cell Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Steidl", 
            "givenName": "Ulrich", 
            "id": "sg:person.01362311426.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362311426.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology, and Clinical Immunology, St Johannes Hospital, Duisburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.459950.4", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, St Johannes Hospital, Duisburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giagounidis", 
            "givenName": "Aristoteles Achilles Nikolaus", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuendgen", 
            "givenName": "Andrea", 
            "id": "sg:person.01022105364.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022105364.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239395.7", 
              "name": [
                "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Otu", 
            "givenName": "Hasan", 
            "id": "sg:person.01372644504.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372644504.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rong", 
            "givenName": "Astrid", 
            "id": "sg:person.01143545700.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143545700.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239395.7", 
              "name": [
                "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Libermann", 
            "givenName": "Towia A.", 
            "id": "sg:person.0672135204.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672135204.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Germing", 
            "givenName": "Ulrich", 
            "id": "sg:person.01362464041.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362464041.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gattermann", 
            "givenName": "Norbert", 
            "id": "sg:person.01273447501.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haas", 
            "givenName": "Rainer", 
            "id": "sg:person.01127414674.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127414674.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239395.7", 
              "name": [
                "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
                "Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aivado", 
            "givenName": "Manuel", 
            "id": "sg:person.0760154564.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760154564.99"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028468408", 
              "https://doi.org/10.1038/ng765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035141416", 
              "https://doi.org/10.1038/sj.onc.1205854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035975191", 
              "https://doi.org/10.1038/sj.leu.2404136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35076576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027465054", 
              "https://doi.org/10.1038/35076576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050447616", 
              "https://doi.org/10.1038/sj.leu.2402805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028497407", 
              "https://doi.org/10.1038/sj.leu.2404057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0795-638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001857500", 
              "https://doi.org/10.1038/nm0795-638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013983783", 
              "https://doi.org/10.1038/sj.leu.2404135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/315768a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007598178", 
              "https://doi.org/10.1038/315768a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000607804", 
              "https://doi.org/10.1038/sj.leu.2403963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053302515", 
              "https://doi.org/10.1038/sj.leu.2403265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032098793", 
              "https://doi.org/10.1038/sj.leu.2400844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1990.262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009660120", 
              "https://doi.org/10.1038/bjc.1990.262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012461766", 
              "https://doi.org/10.1038/sj.leu.2403481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032274846", 
              "https://doi.org/10.1038/sj.leu.2403021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036687579", 
              "https://doi.org/10.1038/sj.leu.2404215"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-01-20", 
        "datePublishedReg": "2009-01-20", 
        "description": "One feature of the molecular pathology of myelodysplastic syndromes (MDS) is aberrant gene expression. Such aberrations may be related to patient survival, and may indicate to novel diagnostic and therapeutic targets. Therefore, we aimed at identifying aberrant gene expression that is associated with MDS and patient survival. Bone marrow-derived CD34+ hematopoietic progenitor cells from six healthy persons and 16 patients with MDS were analyzed on cDNA macroarrays comprising 1,185 genes. Thereafter, our patients were followed-up for 54 months. We found differential expression of genes that were hitherto unrecognized in the context of MDS. Differential expression of 10 genes was confirmed by quantitative real-time RT-PCR. Hierarchical cluster analysis facilitated the separation of CD34+ cells of normal donors from patients with MDS. More importantly, it also distinguished MDS-patients with short and long survival. Scrutinizing our cDNA macroarray data for genes that are associated with short survival, we found, among others, increased expression of six different genes that encode the proteasome subunits. On the other hand, the most differentially down-regulated gene was IEX-1, which encodes an anti-apoptotic protein. We confirmed its decreased expression on RNA and protein level in an independent validation set of patient samples. The presented data broadens our notion about the molecular pathology of MDS and may lend itself to better identify patients with short survival. Furthermore, our findings may help to define new molecular targets for drug development and therapeutic approaches for patients with poor prognosis.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12185-008-0242-9", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1076985", 
            "issn": [
              "0925-5710", 
              "1865-3774"
            ], 
            "name": "International Journal of Hematology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "89"
          }
        ], 
        "keywords": [
          "myelodysplastic syndrome", 
          "bone marrow-derived CD34", 
          "patient survival", 
          "shorter survival", 
          "molecular pathology", 
          "survival of patients", 
          "context of MDS", 
          "real-time RT-PCR", 
          "aberrant gene expression", 
          "new molecular targets", 
          "quantitative real-time RT-PCR", 
          "hematopoietic progenitor cells", 
          "poor prognosis", 
          "longer survival", 
          "gene expression", 
          "normal donors", 
          "healthy persons", 
          "therapeutic approaches", 
          "therapeutic target", 
          "differential expression", 
          "anti-apoptotic proteins", 
          "patients", 
          "decreased expression", 
          "patient samples", 
          "RT-PCR", 
          "progenitor cells", 
          "molecular targets", 
          "CD34", 
          "protein levels", 
          "survival", 
          "independent validation set", 
          "drug development", 
          "syndrome", 
          "pathology", 
          "IEX-1", 
          "such aberrations", 
          "expression", 
          "cells", 
          "differential gene expression", 
          "proteasome subunits", 
          "validation set", 
          "prognosis", 
          "cDNA macroarray", 
          "genes", 
          "months", 
          "target", 
          "different genes", 
          "aberrations", 
          "donors", 
          "macroarray data", 
          "findings", 
          "persons", 
          "hierarchical cluster analysis", 
          "RNA", 
          "data", 
          "levels", 
          "protein", 
          "macroarray", 
          "subunits", 
          "samples", 
          "development", 
          "cluster analysis", 
          "hand", 
          "analysis", 
          "features", 
          "approach", 
          "context", 
          "notion", 
          "separation", 
          "set"
        ], 
        "name": "Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome", 
        "pagination": "173-187", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1011795347"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12185-008-0242-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19152102"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12185-008-0242-9", 
          "https://app.dimensions.ai/details/publication/pub.1011795347"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T16:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_483.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12185-008-0242-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12185-008-0242-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12185-008-0242-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12185-008-0242-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12185-008-0242-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    379 TRIPLES      21 PREDICATES      131 URIs      107 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12185-008-0242-9 schema:about N190d49ff91e2458bb3fe32e2bb35f8a3
    2 N1d032efd92404587958062182c77b319
    3 N1e626f9bab6946ae96ca7dfce6f73301
    4 N28d803f3cdba4d1e964cc058e6abff37
    5 N2c3d9f3f94b7485aa4064578fd47b106
    6 N2df01da5c87d4695943be36ddb118371
    7 N50749b417566487f8a8ceb3410a4a2a5
    8 N5a52d9300b6d420da57a43ec115526f1
    9 N6c1b110be78f4b61af86d621af1b6d5f
    10 N7125b4c674ac4c8c80947a75cf970ad3
    11 N71cd091d201b404aaebf9e07ce3892dc
    12 N727676011f9a4bf48a9607a217fb4dcf
    13 N7eb4aeeb53894c55aa98b73e65cf5b4b
    14 N7f3516cc6122462bbffc24c0312bc41c
    15 Na36deb115f70485f86cfae9eb35b6267
    16 Nb73ae54345c442bf84a068aa7678f5ef
    17 Ne0647dce6b6f49b1b4e0103ed99a0967
    18 Nf3e26a39d77648cab56a9fef7c1d0b97
    19 Nfe23e7f82a2e40e680a8da0ac8f59971
    20 Nff862a5644ab41e689d46331864ae20a
    21 anzsrc-for:11
    22 anzsrc-for:1102
    23 schema:author N9fca5fcdc71e4117b037f025658e68a4
    24 schema:citation sg:pub.10.1038/315768a0
    25 sg:pub.10.1038/35076576
    26 sg:pub.10.1038/bjc.1990.262
    27 sg:pub.10.1038/ng765
    28 sg:pub.10.1038/nm0795-638
    29 sg:pub.10.1038/sj.leu.2400844
    30 sg:pub.10.1038/sj.leu.2402805
    31 sg:pub.10.1038/sj.leu.2403021
    32 sg:pub.10.1038/sj.leu.2403265
    33 sg:pub.10.1038/sj.leu.2403481
    34 sg:pub.10.1038/sj.leu.2403963
    35 sg:pub.10.1038/sj.leu.2404057
    36 sg:pub.10.1038/sj.leu.2404135
    37 sg:pub.10.1038/sj.leu.2404136
    38 sg:pub.10.1038/sj.leu.2404215
    39 sg:pub.10.1038/sj.onc.1205854
    40 schema:datePublished 2009-01-20
    41 schema:datePublishedReg 2009-01-20
    42 schema:description One feature of the molecular pathology of myelodysplastic syndromes (MDS) is aberrant gene expression. Such aberrations may be related to patient survival, and may indicate to novel diagnostic and therapeutic targets. Therefore, we aimed at identifying aberrant gene expression that is associated with MDS and patient survival. Bone marrow-derived CD34+ hematopoietic progenitor cells from six healthy persons and 16 patients with MDS were analyzed on cDNA macroarrays comprising 1,185 genes. Thereafter, our patients were followed-up for 54 months. We found differential expression of genes that were hitherto unrecognized in the context of MDS. Differential expression of 10 genes was confirmed by quantitative real-time RT-PCR. Hierarchical cluster analysis facilitated the separation of CD34+ cells of normal donors from patients with MDS. More importantly, it also distinguished MDS-patients with short and long survival. Scrutinizing our cDNA macroarray data for genes that are associated with short survival, we found, among others, increased expression of six different genes that encode the proteasome subunits. On the other hand, the most differentially down-regulated gene was IEX-1, which encodes an anti-apoptotic protein. We confirmed its decreased expression on RNA and protein level in an independent validation set of patient samples. The presented data broadens our notion about the molecular pathology of MDS and may lend itself to better identify patients with short survival. Furthermore, our findings may help to define new molecular targets for drug development and therapeutic approaches for patients with poor prognosis.
    43 schema:genre article
    44 schema:isAccessibleForFree false
    45 schema:isPartOf N3e4320bf25294d33994a0d55d5c7269f
    46 N6b42630d33074aaa9c588283d89ac4a9
    47 sg:journal.1076985
    48 schema:keywords CD34
    49 IEX-1
    50 RNA
    51 RT-PCR
    52 aberrant gene expression
    53 aberrations
    54 analysis
    55 anti-apoptotic proteins
    56 approach
    57 bone marrow-derived CD34
    58 cDNA macroarray
    59 cells
    60 cluster analysis
    61 context
    62 context of MDS
    63 data
    64 decreased expression
    65 development
    66 different genes
    67 differential expression
    68 differential gene expression
    69 donors
    70 drug development
    71 expression
    72 features
    73 findings
    74 gene expression
    75 genes
    76 hand
    77 healthy persons
    78 hematopoietic progenitor cells
    79 hierarchical cluster analysis
    80 independent validation set
    81 levels
    82 longer survival
    83 macroarray
    84 macroarray data
    85 molecular pathology
    86 molecular targets
    87 months
    88 myelodysplastic syndrome
    89 new molecular targets
    90 normal donors
    91 notion
    92 pathology
    93 patient samples
    94 patient survival
    95 patients
    96 persons
    97 poor prognosis
    98 progenitor cells
    99 prognosis
    100 proteasome subunits
    101 protein
    102 protein levels
    103 quantitative real-time RT-PCR
    104 real-time RT-PCR
    105 samples
    106 separation
    107 set
    108 shorter survival
    109 subunits
    110 such aberrations
    111 survival
    112 survival of patients
    113 syndrome
    114 target
    115 therapeutic approaches
    116 therapeutic target
    117 validation set
    118 schema:name Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome
    119 schema:pagination 173-187
    120 schema:productId Na624b56ae9904613b7db95e2bc2feb63
    121 Naa6d6051e64a466db57b1c74fcdfb91a
    122 Ne176e36cf6a346e9b4ea363b7823d9ff
    123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011795347
    124 https://doi.org/10.1007/s12185-008-0242-9
    125 schema:sdDatePublished 2022-08-04T16:58
    126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    127 schema:sdPublisher Nb0c8c8640719426caa5f7e8efb60fe48
    128 schema:url https://doi.org/10.1007/s12185-008-0242-9
    129 sgo:license sg:explorer/license/
    130 sgo:sdDataset articles
    131 rdf:type schema:ScholarlyArticle
    132 N0a57c587b6b64b7586e1264618232949 rdf:first sg:person.0760154564.99
    133 rdf:rest rdf:nil
    134 N112cfa3a4f3240c9b64df1132065b14f rdf:first sg:person.01362311426.38
    135 rdf:rest N4bcdd8db8eb249709dbefa957f91ece4
    136 N131d048d76104c8d996870b121715b6b rdf:first sg:person.01032642115.04
    137 rdf:rest N22f4e2906c604375b59327609f59840b
    138 N190d49ff91e2458bb3fe32e2bb35f8a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Hematopoietic Stem Cells
    140 rdf:type schema:DefinedTerm
    141 N1d032efd92404587958062182c77b319 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Bone Marrow Cells
    143 rdf:type schema:DefinedTerm
    144 N1e626f9bab6946ae96ca7dfce6f73301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Female
    146 rdf:type schema:DefinedTerm
    147 N1fde4bdcf4b54501b596b19cc1b575ba rdf:first sg:person.0672135204.23
    148 rdf:rest N671af4e5cb5e4b7caa75772ca4cd1ab7
    149 N22f4e2906c604375b59327609f59840b rdf:first sg:person.0734407304.72
    150 rdf:rest N354bc350ba4a486f9f2d0ce5ad27a819
    151 N28d803f3cdba4d1e964cc058e6abff37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Survival Rate
    153 rdf:type schema:DefinedTerm
    154 N2c3d9f3f94b7485aa4064578fd47b106 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Adolescent
    156 rdf:type schema:DefinedTerm
    157 N2df01da5c87d4695943be36ddb118371 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Myelodysplastic Syndromes
    159 rdf:type schema:DefinedTerm
    160 N354bc350ba4a486f9f2d0ce5ad27a819 rdf:first sg:person.0643726164.47
    161 rdf:rest N112cfa3a4f3240c9b64df1132065b14f
    162 N3e4320bf25294d33994a0d55d5c7269f schema:issueNumber 2
    163 rdf:type schema:PublicationIssue
    164 N46ec75878de04a8fbf1341a317556507 schema:affiliation grid-institutes:grid.459950.4
    165 schema:familyName Giagounidis
    166 schema:givenName Aristoteles Achilles Nikolaus
    167 rdf:type schema:Person
    168 N497382bbe1ef4b3d921c28d6ed88df81 rdf:first sg:person.01372644504.42
    169 rdf:rest Nc04fb47d23004cc4921e60d6113d9e35
    170 N4bcdd8db8eb249709dbefa957f91ece4 rdf:first N46ec75878de04a8fbf1341a317556507
    171 rdf:rest Nca2e548455694a3dac34a8182775aff4
    172 N50749b417566487f8a8ceb3410a4a2a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Apoptosis Regulatory Proteins
    174 rdf:type schema:DefinedTerm
    175 N5a52d9300b6d420da57a43ec115526f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Adult
    177 rdf:type schema:DefinedTerm
    178 N6214fcf9850641d0ad26a94c98a3bca3 rdf:first sg:person.01273447501.34
    179 rdf:rest Ncb86af63562d4cceb44d81eeaf8f5788
    180 N671af4e5cb5e4b7caa75772ca4cd1ab7 rdf:first sg:person.01362464041.20
    181 rdf:rest N6214fcf9850641d0ad26a94c98a3bca3
    182 N6b42630d33074aaa9c588283d89ac4a9 schema:volumeNumber 89
    183 rdf:type schema:PublicationVolume
    184 N6c1b110be78f4b61af86d621af1b6d5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Membrane Proteins
    186 rdf:type schema:DefinedTerm
    187 N7125b4c674ac4c8c80947a75cf970ad3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Aged, 80 and over
    189 rdf:type schema:DefinedTerm
    190 N71cd091d201b404aaebf9e07ce3892dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Prognosis
    192 rdf:type schema:DefinedTerm
    193 N727676011f9a4bf48a9607a217fb4dcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Young Adult
    195 rdf:type schema:DefinedTerm
    196 N7eb4aeeb53894c55aa98b73e65cf5b4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Gene Expression Profiling
    198 rdf:type schema:DefinedTerm
    199 N7f3516cc6122462bbffc24c0312bc41c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Antigens, CD34
    201 rdf:type schema:DefinedTerm
    202 N9fca5fcdc71e4117b037f025658e68a4 rdf:first sg:person.01360642667.41
    203 rdf:rest N131d048d76104c8d996870b121715b6b
    204 Na36deb115f70485f86cfae9eb35b6267 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Middle Aged
    206 rdf:type schema:DefinedTerm
    207 Na624b56ae9904613b7db95e2bc2feb63 schema:name pubmed_id
    208 schema:value 19152102
    209 rdf:type schema:PropertyValue
    210 Naa6d6051e64a466db57b1c74fcdfb91a schema:name dimensions_id
    211 schema:value pub.1011795347
    212 rdf:type schema:PropertyValue
    213 Nb0c8c8640719426caa5f7e8efb60fe48 schema:name Springer Nature - SN SciGraph project
    214 rdf:type schema:Organization
    215 Nb73ae54345c442bf84a068aa7678f5ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Aged
    217 rdf:type schema:DefinedTerm
    218 Nc04fb47d23004cc4921e60d6113d9e35 rdf:first sg:person.01143545700.40
    219 rdf:rest N1fde4bdcf4b54501b596b19cc1b575ba
    220 Nca2e548455694a3dac34a8182775aff4 rdf:first sg:person.01022105364.01
    221 rdf:rest N497382bbe1ef4b3d921c28d6ed88df81
    222 Ncb86af63562d4cceb44d81eeaf8f5788 rdf:first sg:person.01127414674.14
    223 rdf:rest N0a57c587b6b64b7586e1264618232949
    224 Ne0647dce6b6f49b1b4e0103ed99a0967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Proteasome Endopeptidase Complex
    226 rdf:type schema:DefinedTerm
    227 Ne176e36cf6a346e9b4ea363b7823d9ff schema:name doi
    228 schema:value 10.1007/s12185-008-0242-9
    229 rdf:type schema:PropertyValue
    230 Nf3e26a39d77648cab56a9fef7c1d0b97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Gene Expression Regulation, Neoplastic
    232 rdf:type schema:DefinedTerm
    233 Nfe23e7f82a2e40e680a8da0ac8f59971 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Male
    235 rdf:type schema:DefinedTerm
    236 Nff862a5644ab41e689d46331864ae20a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Humans
    238 rdf:type schema:DefinedTerm
    239 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    240 schema:name Medical and Health Sciences
    241 rdf:type schema:DefinedTerm
    242 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    243 schema:name Cardiorespiratory Medicine and Haematology
    244 rdf:type schema:DefinedTerm
    245 sg:journal.1076985 schema:issn 0925-5710
    246 1865-3774
    247 schema:name International Journal of Hematology
    248 schema:publisher Springer Nature
    249 rdf:type schema:Periodical
    250 sg:person.01022105364.01 schema:affiliation grid-institutes:grid.411327.2
    251 schema:familyName Kuendgen
    252 schema:givenName Andrea
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022105364.01
    254 rdf:type schema:Person
    255 sg:person.01032642115.04 schema:affiliation grid-institutes:grid.239395.7
    256 schema:familyName Czibere
    257 schema:givenName Akos
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032642115.04
    259 rdf:type schema:Person
    260 sg:person.01127414674.14 schema:affiliation grid-institutes:grid.411327.2
    261 schema:familyName Haas
    262 schema:givenName Rainer
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127414674.14
    264 rdf:type schema:Person
    265 sg:person.01143545700.40 schema:affiliation grid-institutes:grid.411327.2
    266 schema:familyName Rong
    267 schema:givenName Astrid
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143545700.40
    269 rdf:type schema:Person
    270 sg:person.01273447501.34 schema:affiliation grid-institutes:grid.411327.2
    271 schema:familyName Gattermann
    272 schema:givenName Norbert
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34
    274 rdf:type schema:Person
    275 sg:person.01360642667.41 schema:affiliation grid-institutes:grid.5252.0
    276 schema:familyName Prall
    277 schema:givenName Wolf C.
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360642667.41
    279 rdf:type schema:Person
    280 sg:person.01362311426.38 schema:affiliation grid-institutes:grid.251993.5
    281 schema:familyName Steidl
    282 schema:givenName Ulrich
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362311426.38
    284 rdf:type schema:Person
    285 sg:person.01362464041.20 schema:affiliation grid-institutes:grid.411327.2
    286 schema:familyName Germing
    287 schema:givenName Ulrich
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362464041.20
    289 rdf:type schema:Person
    290 sg:person.01372644504.42 schema:affiliation grid-institutes:grid.239395.7
    291 schema:familyName Otu
    292 schema:givenName Hasan
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372644504.42
    294 rdf:type schema:Person
    295 sg:person.0643726164.47 schema:affiliation grid-institutes:grid.239395.7
    296 schema:familyName Spentzos
    297 schema:givenName Dimitrios
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643726164.47
    299 rdf:type schema:Person
    300 sg:person.0672135204.23 schema:affiliation grid-institutes:grid.239395.7
    301 schema:familyName Libermann
    302 schema:givenName Towia A.
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672135204.23
    304 rdf:type schema:Person
    305 sg:person.0734407304.72 schema:affiliation grid-institutes:grid.239395.7
    306 schema:familyName Grall
    307 schema:givenName Franck
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734407304.72
    309 rdf:type schema:Person
    310 sg:person.0760154564.99 schema:affiliation grid-institutes:grid.239395.7
    311 schema:familyName Aivado
    312 schema:givenName Manuel
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760154564.99
    314 rdf:type schema:Person
    315 sg:pub.10.1038/315768a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007598178
    316 https://doi.org/10.1038/315768a0
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/35076576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027465054
    319 https://doi.org/10.1038/35076576
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/bjc.1990.262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009660120
    322 https://doi.org/10.1038/bjc.1990.262
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/ng765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028468408
    325 https://doi.org/10.1038/ng765
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nm0795-638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001857500
    328 https://doi.org/10.1038/nm0795-638
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/sj.leu.2400844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032098793
    331 https://doi.org/10.1038/sj.leu.2400844
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/sj.leu.2402805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050447616
    334 https://doi.org/10.1038/sj.leu.2402805
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/sj.leu.2403021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032274846
    337 https://doi.org/10.1038/sj.leu.2403021
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/sj.leu.2403265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053302515
    340 https://doi.org/10.1038/sj.leu.2403265
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/sj.leu.2403481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012461766
    343 https://doi.org/10.1038/sj.leu.2403481
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/sj.leu.2403963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000607804
    346 https://doi.org/10.1038/sj.leu.2403963
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/sj.leu.2404057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028497407
    349 https://doi.org/10.1038/sj.leu.2404057
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/sj.leu.2404135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013983783
    352 https://doi.org/10.1038/sj.leu.2404135
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/sj.leu.2404136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035975191
    355 https://doi.org/10.1038/sj.leu.2404136
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/sj.leu.2404215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036687579
    358 https://doi.org/10.1038/sj.leu.2404215
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/sj.onc.1205854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035141416
    361 https://doi.org/10.1038/sj.onc.1205854
    362 rdf:type schema:CreativeWork
    363 grid-institutes:grid.239395.7 schema:alternateName Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA
    364 schema:name Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA
    365 Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany
    366 rdf:type schema:Organization
    367 grid-institutes:grid.251993.5 schema:alternateName Department of Cell Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA
    368 schema:name Department of Cell Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA
    369 rdf:type schema:Organization
    370 grid-institutes:grid.411327.2 schema:alternateName Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany
    371 schema:name Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany
    372 rdf:type schema:Organization
    373 grid-institutes:grid.459950.4 schema:alternateName Department of Hematology, Oncology, and Clinical Immunology, St Johannes Hospital, Duisburg, Germany
    374 schema:name Department of Hematology, Oncology, and Clinical Immunology, St Johannes Hospital, Duisburg, Germany
    375 rdf:type schema:Organization
    376 grid-institutes:grid.5252.0 schema:alternateName Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University, Nussbaumstraße 20, 80336, Munich, Germany
    377 schema:name Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany
    378 Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University, Nussbaumstraße 20, 80336, Munich, Germany
    379 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...