Molecular and cytogenetic response of chronic myelogenous leukemia treated with imatinib mesylate: one institutional experience in Japan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-09

AUTHORS

Yasuhito Nannya, Hiromitsu Yokota, Yumiko Sato, Go Yamamoto, Takashi Asai, Motoshi Ichikawa, Takuro Watanabe, Keiki Kumano, Akira Hangaishi, Tsuyoshi Takahashi, Shigeru Chiba, Yutaka Yatomi, Mineo Kurokawa

ABSTRACT

We retrospectively analyzed the clinical outcome of chronic myelogenous leukemia (CML) patients who received imatinib mesylate (IM) as initial therapy at Tokyo University Hospital. In all patients, molecular response as well as hematological and cytogenetic response was measured routinely. Our cohort showed respectable outcome with complete cytogenetic response (CR) of 82% in 1 year, and 97% in 5 years. The estimated progression free survival of 29 patients who were in chronic phase at diagnosis was 97% and the estimated OS was 92.4% at 5 years. Although IM interruption due to side effects was observed in about half of the cases, the discontinuation was only temporary in all cases. However, patients who showed persistent intolerance with adequate dose of IM (300 mg/day or more) showed poor molecular response. More... »

PAGES

159-164

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-008-0111-6

DOI

http://dx.doi.org/10.1007/s12185-008-0111-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030784811

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18560751


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