ESHAP therapy effective in a patient with Langerhans cell sarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06

AUTHORS

Akihide Yoshimi, Keiki Kumano, Toru Motokura, Yutaka Takazawa, Satoshi Oota, Shigeru Chiba, Tsuyoshi Takahashi, Masashi Fukayama, Mineo Kurokawa

ABSTRACT

We describe the rare case of a 53-year-old woman with systemic involvement of Langerhans cell sarcoma (LCS) who had undergone living-related liver transplantation. We chose the CHOP regimen as first-line chemotherapy, and clinical improvement of LCS was obtained. Intensive care was necessary due to the systemic involvement of LCS and severe infectious diseases. After the third cycle of CHOP therapy, however, disease progression was observed, and we administrated a modified ESHAP regimen (etoposide, carboplatin, cytarabine, methylprednisolone) as second-line therapy. A marked response was obtained after four cycles of this combination chemotherapy. Modified ESHAP may be a very effective combination chemotherapy regimen for LCS. More... »

PAGES

532-537

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-008-0075-6

DOI

http://dx.doi.org/10.1007/s12185-008-0075-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038783031

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18415657


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39 schema:description We describe the rare case of a 53-year-old woman with systemic involvement of Langerhans cell sarcoma (LCS) who had undergone living-related liver transplantation. We chose the CHOP regimen as first-line chemotherapy, and clinical improvement of LCS was obtained. Intensive care was necessary due to the systemic involvement of LCS and severe infectious diseases. After the third cycle of CHOP therapy, however, disease progression was observed, and we administrated a modified ESHAP regimen (etoposide, carboplatin, cytarabine, methylprednisolone) as second-line therapy. A marked response was obtained after four cycles of this combination chemotherapy. Modified ESHAP may be a very effective combination chemotherapy regimen for LCS.
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