MLL gene fusions in human leukaemias: in vivo modelling to recapitulate these primary tumourigenic events View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

S. Rodriguez-Perales, F. Cano, M. N. Lobato, T. H. Rabbitts

ABSTRACT

Recurrent reciprocal chromosomal translocations are frequently found in leukaemias and sarcomas as initiating events in these cancers. Mouse models of chromosomal translocations are not only important for the elucidation of the mechanism of these factors underlying the disease but are also important pre-clinical models for assessing new drug combinations, developing new rational therapeutic strategies based on new drugs and testing novel macromolecular drugs. We describe three technologies for creating chromosomal translocation mimics in mice, applied specifically to understand how the MLL-fusions contribute to leukaemia. An important finding of this work is that the lineage of the tumours can be controlled by the MLL-protein fusion. The translocation mimic methods can be applied to any human reciprocal chromosomal translocation. More... »

PAGES

3-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-007-0001-3

DOI

http://dx.doi.org/10.1007/s12185-007-0001-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035914333

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18224407


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