Les tumeurs stromales digestives « GIST » : étude rétrospective de dix cas au Sénégal View Full Text


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Article Info

DATE

2011-09

AUTHORS

F. Fall, B. Ndiaye, A. R. Ndiaye, N. M. Diagne Guèye, S. B. Gning, A. Niang, T. O. Soko, A. R. Ndiaye, I. Diallo, M. Ogougbémy, M. B. Diouf, P. S. Mbaye

ABSTRACT

Décrire les aspects épidémiologiques, cliniques, paracliniques, thérapeutiques et évolutifs des tumeurs stromales digestives à l’hôpital Principal de Dakar. Étude rétrospective descriptive réalisée de février 2002 à février 2010, soit pendant huit ans, ayant inclus tous les malades hospitalisés dans les services de médecine interne pour tumeur stromale digestive. Dix tumeurs stromales digestives ont été colligées. L’âge moyen des patients était de 52,5 ans (39–67 ans), le sex-ratio de 2,3. Les manifestations cliniques étaient: une masse abdominale (n = 7), une altération de l’état général (n = 6), des douleurs abdominales (n = 5), une hématémèse (n = 1). L’examen histologique montrait une prolifération de cellules fusiformes exprimant en immunohistochimie les marqueurs CD117 (c-kit) et CD34. L’étude de l’extension montrait une tumeur localisée dans quatre cas et des métastases dans six cas. Une chirurgie à visée curative était réalisée dans trois cas. Un traitement médical à base de mésylate d’imatinib (Glivec®) était instauré chez quatre patients qui présentaient une tumeur non résécable (n = 1), une tumeur d’emblée métastatique (n = 1) et une tumeur récidivante (n = 2). L’évolution était bonne chez tous les patients traités. Trois patients dont la maladie était très évoluée sont décédés avant l’instauration d’un traitement et deux ont été perdus de vue. Une récidive locale et métastatique est apparue chez deux patients à 6 et 17 mois de la chirurgie. La survie moyenne était de 62 mois (29–96 mois). Les tumeurs stromales digestives sont rares au Sénégal et présentent le même profil épidémiologique que celles qui sont diagnostiquées dans les pays occidentaux et asiatiques. Elles expriment les marqueurs CD117 et CD34 et sont souvent diagnostiquées au stade métastatique. L’efficacité du Glivec® est démontrée dans ces cas. Nos patients en bénéficient malgré son coût prohibitif grâce au programme GIPAP (GIPAP: Glivec® International Patients Assistance Program). More... »

PAGES

210

Journal

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12157-011-0290-2

DOI

http://dx.doi.org/10.1007/s12157-011-0290-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038618739


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