Tumeurs stromales gastrointestinales (GIST) et thérapies ciblées: évolution des indications chirurgicales à propos d’une série de 13 cas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-06

AUTHORS

I. Sall, H. El Kaoui, A. Ait Ali, A. Bounaim, S. -M. Bouchentouf, R. Tanz, Y. Sbiti, A. El Hjouji, M. El Fahssi, M. Ichou, A. Aouragh, A. Benkirane, A. Zentar, K. Sair

ABSTRACT

Imatinib (Imb) et tumeur stromale gastrointestinale (GIST) forment le modèle exemplaire du succès des thérapeutiques moléculaires ciblées. Parallèlement, il a été nécessaire de redéfinir la place de la chirurgie qui continue, toutefois, à faire partie intégrante de la prise en charge thérapeutique des GIST. De 2003 à 2008, nous avons eu à traiter 13 cas de tumeurs stromales digestives. L’évaluation de l’agressivité tumorale se basait sur les critères de Fletcher. Le bilan d’extension et l’évaluation de la réponse tumorale sous Imb étaient fondés, essentiellement, sur la tomodensitométrie. L’Imb était prescrit pour les GIST non résécables en dehors des indications chirurgicales urgentes et les récidives tumorales. La résection chirurgicale était indiquée à chaque fois que la possibilité d’une résection R0 était avérée sur les données morphologiques. Dans notre série, trois patients ont été admis dans un tableau d’urgence. Pour les dix patients restants, l’hémorragie digestive a été le maître symptôme. Douze patients ont subi une intervention chirurgicale. Neuf patients présentaient des GIST à haut risque évolutif. Un patient a présenté une récidive après une résection complète. établir un diagnostic positif préopératoire semble la première étape pour garantir une prise en charge optimale. Le traitement chirurgical doit rester une priorité à chaque fois qu’une résection complète est possible d’emblée ou après réduction tumorale sous Imb. Dans tous les autres cas, et en dehors de l’urgence, la prescription de l’Imb sera la priorité. More... »

PAGES

75-80

References to SciGraph publications

Journal

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12157-009-0087-8

DOI

http://dx.doi.org/10.1007/s12157-009-0087-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008849148


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16 schema:description Imatinib (Imb) et tumeur stromale gastrointestinale (GIST) forment le modèle exemplaire du succès des thérapeutiques moléculaires ciblées. Parallèlement, il a été nécessaire de redéfinir la place de la chirurgie qui continue, toutefois, à faire partie intégrante de la prise en charge thérapeutique des GIST. De 2003 à 2008, nous avons eu à traiter 13 cas de tumeurs stromales digestives. L’évaluation de l’agressivité tumorale se basait sur les critères de Fletcher. Le bilan d’extension et l’évaluation de la réponse tumorale sous Imb étaient fondés, essentiellement, sur la tomodensitométrie. L’Imb était prescrit pour les GIST non résécables en dehors des indications chirurgicales urgentes et les récidives tumorales. La résection chirurgicale était indiquée à chaque fois que la possibilité d’une résection R0 était avérée sur les données morphologiques. Dans notre série, trois patients ont été admis dans un tableau d’urgence. Pour les dix patients restants, l’hémorragie digestive a été le maître symptôme. Douze patients ont subi une intervention chirurgicale. Neuf patients présentaient des GIST à haut risque évolutif. Un patient a présenté une récidive après une résection complète. établir un diagnostic positif préopératoire semble la première étape pour garantir une prise en charge optimale. Le traitement chirurgical doit rester une priorité à chaque fois qu’une résection complète est possible d’emblée ou après réduction tumorale sous Imb. Dans tous les autres cas, et en dehors de l’urgence, la prescription de l’Imb sera la priorité.
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