Hepatocarcinoma: from pathogenic mechanisms to target therapy View Full Text


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Article Info

DATE

2008-11-17

AUTHORS

Luigi Manzione, Antonio Maria Grimaldi, Rosangela Romano, Domenica Ferrara, Angelo Dinota

ABSTRACT

Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers worldwide. It is currently estimated that there are 14,000–18,000 new cases of hepatocellular carcinoma in the United States each year. It is often difficult to identify individuals at risk for HCC. The main associated diseases are chronic hepatitis B and chronic hepatitis C viral infections. While a significant number of potential mutations have been generated including p53 and Insulin-like Growth Factor, our understanding of the molecular mechanisms driving the genesis and progression of HCC remain limited. HCC screening is recommended in high-risk patients. High-risk patients include virtually all patients with cirrhosis and some HBV-infected patients irrespective of cirrhosis (>40 years in men and >50 years in women). A diagnostic approach to HCC has been developed incorporating serology, cytohistology, and radiological characteristics. A precise staging of the disease may help decide on prognosis as well as choice of therapy with the greatest survival potential. Liver transplantation, in theory, is the optimal therapeutic option for HCC; it simultaneously removes the tumor and underlying cirrhosis thus minimizing the risk of HCC recurrence. When it is impossible for this to be performed, percutaneous ablation, chemoembolization, chemotherapy and the newer molecular therapies can be used. Sorafenib is the only drug registered today for the treatment of advanced HCC. More... »

PAGES

214-222

References to SciGraph publications

  • 1998-12-01. Serum alpha-fetoprotein levels and liver histology in patients with chronic hepatitis C in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2006-06-26. RNA interference-mediated prevention and therapy for hepatocellular carcinoma in ONCOGENE
  • 2006-06-26. Dysregulation of growth factor signaling in human hepatocellular carcinoma in ONCOGENE
  • 2002-03-01. Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience) in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2006-06-26. New aspects of diagnosis and therapy of hepatocellular carcinoma in ONCOGENE
  • 1991-03. Surgical treatment of hepatocellular carcinoma: Experience with liver resection and transplantation in 198 patients in WORLD JOURNAL OF SURGERY
  • 2003-03-01. Screening for Hepatocellular Carcinoma in Patients With Hepatitis C Cirrhosis: A Cost-Utility Analysis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2004-03-20. Randomized controlled trial of screening for hepatocellular carcinoma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2006-12-08. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2007-05-23. The Clinical Outcome of Small (<20 mm) Arterially Enhancing Nodules on MRI in the Cirrhotic Liver in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2004-07-10. Phase II study of doxorubicin and cisplatin in patients with metastatic hepatocellular carcinoma in CANCER CHEMOTHERAPY AND PHARMACOLOGY
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