18F-FDG PET/CT of off-target lymphoid organs in CD19-targeting chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-11

AUTHORS

Thorsten Derlin, Christian Schultze-Florey, Rudolf A. Werner, Nora Möhn, Thomas Skripuletz, Sascha David, Gernot Beutel, Matthias Eder, Tobias L. Ross, Frank M. Bengel, Arnold Ganser, Christian Koenecke

ABSTRACT

ObjectiveThe interplay between systemic inflammation, activity of lymphoid organs and lymphoma activity in CD19-targeting chimeric antigen receptor (CAR)-T-cell immunotherapy, and its significance for response and toxicity, is not well defined.MethodsUsing serial 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), metabolic parameters of lymphoma and lymphoid organs were analyzed in ten patients receiving Tisagenlecleucel (an autologous CD19 CAR-T cell product) for relapsed or refractory diffuse large B-cell lymphoma. The prevalence and severity of toxicity (e.g., neurotoxicity) were noted.ResultsAchieving remission required early metabolic response (P = 0.0476). Early suppression of metabolic activity of lymphoid organs (spleen, P = 0.0368; lymph nodes, P = 0.0470) was associated with poor outcome. Lymphoma metabolic activity was significantly higher in patients with neurotoxicity (P = 0.0489).ConclusionsEarly metabolic changes in lymphoma lesions and off-target lymphoid organs parallel medium-term response to CAR-T-cell therapy. PET can identify patients at risk for severe toxicity. More... »

PAGES

132-138

References to SciGraph publications

  • 2015-01-20. Assessment of bone marrow inflammation in patients with myelofibrosis: an 18F-fluorodeoxyglucose PET/CT study in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12149-020-01544-w

    DOI

    http://dx.doi.org/10.1007/s12149-020-01544-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132507659

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33174144


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, CD19", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorodeoxyglucose F18", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunotherapy, Adoptive", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoma, Large B-Cell, Diffuse", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Positron Emission Tomography Computed Tomography", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Chimeric Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recurrence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Failure", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/grid.10423.34", 
              "name": [
                "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Derlin", 
            "givenName": "Thorsten", 
            "id": "sg:person.0704554652.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704554652.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schultze-Florey", 
            "givenName": "Christian", 
            "id": "sg:person.0576060453.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576060453.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/grid.10423.34", 
              "name": [
                "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Werner", 
            "givenName": "Rudolf A.", 
            "id": "sg:person.01006720774.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006720774.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Neurology, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00f6hn", 
            "givenName": "Nora", 
            "id": "sg:person.0743710055.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743710055.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Neurology, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Skripuletz", 
            "givenName": "Thomas", 
            "id": "sg:person.01322477140.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322477140.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Hannover Medical School, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/grid.10423.34", 
              "name": [
                "Department of Nephrology, Hannover Medical School, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "David", 
            "givenName": "Sascha", 
            "id": "sg:person.01343324136.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343324136.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beutel", 
            "givenName": "Gernot", 
            "id": "sg:person.01037024564.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037024564.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eder", 
            "givenName": "Matthias", 
            "id": "sg:person.0763175305.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763175305.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/grid.10423.34", 
              "name": [
                "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ross", 
            "givenName": "Tobias L.", 
            "id": "sg:person.01057176500.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057176500.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/grid.10423.34", 
              "name": [
                "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bengel", 
            "givenName": "Frank M.", 
            "id": "sg:person.01225020511.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225020511.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ganser", 
            "givenName": "Arnold", 
            "id": "sg:person.01225227464.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225227464.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koenecke", 
            "givenName": "Christian", 
            "id": "sg:person.01221366364.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221366364.07"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00259-014-2983-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046004455", 
              "https://doi.org/10.1007/s00259-014-2983-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-11-11", 
        "datePublishedReg": "2020-11-11", 
        "description": "ObjectiveThe interplay between systemic inflammation, activity of lymphoid organs and lymphoma activity in CD19-targeting chimeric antigen receptor (CAR)-T-cell immunotherapy, and its significance for response and toxicity, is not well defined.MethodsUsing serial 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), metabolic parameters of lymphoma and lymphoid organs were analyzed in ten patients receiving Tisagenlecleucel (an autologous CD19 CAR-T cell product) for relapsed or refractory diffuse large B-cell lymphoma. The prevalence and severity of toxicity (e.g., neurotoxicity) were noted.ResultsAchieving remission required early metabolic response (P\u2009=\u20090.0476). Early suppression of metabolic activity of lymphoid organs (spleen, P\u2009=\u20090.0368; lymph nodes, P\u2009=\u20090.0470) was associated with poor outcome. Lymphoma metabolic activity was significantly higher in patients with neurotoxicity (P\u2009=\u20090.0489).ConclusionsEarly metabolic changes in lymphoma lesions and off-target lymphoid organs parallel medium-term response to CAR-T-cell therapy. PET can identify patients at risk for severe toxicity.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12149-020-01544-w", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1099601", 
            "issn": [
              "0914-7187", 
              "1864-6433"
            ], 
            "name": "Annals of Nuclear Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "35"
          }
        ], 
        "keywords": [
          "refractory diffuse large B-cell lymphoma", 
          "diffuse large B-cell lymphoma", 
          "large B-cell lymphoma", 
          "lymphoid organs", 
          "B-cell lymphoma", 
          "chimeric antigen receptor T-cell therapy", 
          "positron emission tomography/", 
          "CAR T-cell therapy", 
          "T-cell therapy", 
          "T-cell immunotherapy", 
          "emission tomography/", 
          "chimeric antigen receptor", 
          "early metabolic response", 
          "PET/CT", 
          "severity of toxicity", 
          "systemic inflammation", 
          "poor outcome", 
          "lymphoma lesions", 
          "tomography/", 
          "metabolic parameters", 
          "lymphoma activity", 
          "severe toxicity", 
          "metabolic activity", 
          "early suppression", 
          "patients", 
          "lymphoma", 
          "antigen receptor", 
          "metabolic changes", 
          "metabolic response", 
          "CD19", 
          "therapy", 
          "organs", 
          "toxicity", 
          "remission", 
          "immunotherapy", 
          "response", 
          "tisagenlecleucel", 
          "inflammation", 
          "neurotoxicity", 
          "lesions", 
          "activity", 
          "prevalence", 
          "MethodsUsing", 
          "severity", 
          "CT", 
          "receptors", 
          "tomography", 
          "outcomes", 
          "risk", 
          "PET", 
          "suppression", 
          "medium-term responses", 
          "significance", 
          "changes", 
          "interplay", 
          "parameters"
        ], 
        "name": "18F-FDG PET/CT of off-target lymphoid organs in CD19-targeting chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell lymphoma", 
        "pagination": "132-138", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1132507659"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12149-020-01544-w"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33174144"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12149-020-01544-w", 
          "https://app.dimensions.ai/details/publication/pub.1132507659"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_854.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12149-020-01544-w"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12149-020-01544-w'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12149-020-01544-w'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12149-020-01544-w'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12149-020-01544-w'


     

    This table displays all metadata directly associated to this object as RDF triples.

    261 TRIPLES      21 PREDICATES      96 URIs      87 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12149-020-01544-w schema:about N09581417ff4642c59dc0fa0d7b7f6ac5
    2 N14a8299da69744e4be954bcff8cc3f45
    3 N37a1778339c442e784df25e00fb94ed1
    4 N39d81f53d64442fca4921adf07c90411
    5 N6a128ae9308a42b0ba4f0a3e702f1f15
    6 N6a4c2a5d64a24583a5a832e017a1e2e5
    7 N6e05b24a1c3d477390c3be9f9807f5fb
    8 N7a5d8ed9279e4947a98d819959378bec
    9 N83b1fd07517f4574a428615b6a991845
    10 N84f71029bb504a958b5f70befc0de58d
    11 N8e08423b670b47b9a73b871ec6ff1319
    12 Nb089fe878cd64c0987bf3dbe2d45aa7b
    13 Nba4d5d4d7d0b4378bac463b90c70752f
    14 Ne43116b969f14a539e78bd220b0ab25e
    15 anzsrc-for:11
    16 anzsrc-for:1103
    17 schema:author Na19f50b9a3154ae1810f242e1397d660
    18 schema:citation sg:pub.10.1007/s00259-014-2983-4
    19 schema:datePublished 2020-11-11
    20 schema:datePublishedReg 2020-11-11
    21 schema:description ObjectiveThe interplay between systemic inflammation, activity of lymphoid organs and lymphoma activity in CD19-targeting chimeric antigen receptor (CAR)-T-cell immunotherapy, and its significance for response and toxicity, is not well defined.MethodsUsing serial 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), metabolic parameters of lymphoma and lymphoid organs were analyzed in ten patients receiving Tisagenlecleucel (an autologous CD19 CAR-T cell product) for relapsed or refractory diffuse large B-cell lymphoma. The prevalence and severity of toxicity (e.g., neurotoxicity) were noted.ResultsAchieving remission required early metabolic response (P = 0.0476). Early suppression of metabolic activity of lymphoid organs (spleen, P = 0.0368; lymph nodes, P = 0.0470) was associated with poor outcome. Lymphoma metabolic activity was significantly higher in patients with neurotoxicity (P = 0.0489).ConclusionsEarly metabolic changes in lymphoma lesions and off-target lymphoid organs parallel medium-term response to CAR-T-cell therapy. PET can identify patients at risk for severe toxicity.
    22 schema:genre article
    23 schema:isAccessibleForFree true
    24 schema:isPartOf N1666bc1d0f9d4e0ab55bd85792c113bb
    25 Na5df2c11d2454b798e0a320321023f48
    26 sg:journal.1099601
    27 schema:keywords B-cell lymphoma
    28 CAR T-cell therapy
    29 CD19
    30 CT
    31 MethodsUsing
    32 PET
    33 PET/CT
    34 T-cell immunotherapy
    35 T-cell therapy
    36 activity
    37 antigen receptor
    38 changes
    39 chimeric antigen receptor
    40 chimeric antigen receptor T-cell therapy
    41 diffuse large B-cell lymphoma
    42 early metabolic response
    43 early suppression
    44 emission tomography/
    45 immunotherapy
    46 inflammation
    47 interplay
    48 large B-cell lymphoma
    49 lesions
    50 lymphoid organs
    51 lymphoma
    52 lymphoma activity
    53 lymphoma lesions
    54 medium-term responses
    55 metabolic activity
    56 metabolic changes
    57 metabolic parameters
    58 metabolic response
    59 neurotoxicity
    60 organs
    61 outcomes
    62 parameters
    63 patients
    64 poor outcome
    65 positron emission tomography/
    66 prevalence
    67 receptors
    68 refractory diffuse large B-cell lymphoma
    69 remission
    70 response
    71 risk
    72 severe toxicity
    73 severity
    74 severity of toxicity
    75 significance
    76 suppression
    77 systemic inflammation
    78 therapy
    79 tisagenlecleucel
    80 tomography
    81 tomography/
    82 toxicity
    83 schema:name 18F-FDG PET/CT of off-target lymphoid organs in CD19-targeting chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell lymphoma
    84 schema:pagination 132-138
    85 schema:productId N7655908b304e4acf8bfffb95e6a14821
    86 Na513c04bf7ff4b889663b74fb83c1040
    87 Nf6f9558a15df4cb0896e361f572f0130
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132507659
    89 https://doi.org/10.1007/s12149-020-01544-w
    90 schema:sdDatePublished 2022-12-01T06:40
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher Nfc6773e831434fb8adea496b599563d8
    93 schema:url https://doi.org/10.1007/s12149-020-01544-w
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N09581417ff4642c59dc0fa0d7b7f6ac5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Recurrence
    99 rdf:type schema:DefinedTerm
    100 N1387a09057014a7491e86ebbfc968ecc rdf:first sg:person.01037024564.42
    101 rdf:rest Nab177e9d230d4e36ad6546222819c63d
    102 N14a8299da69744e4be954bcff8cc3f45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Adult
    104 rdf:type schema:DefinedTerm
    105 N1666bc1d0f9d4e0ab55bd85792c113bb schema:volumeNumber 35
    106 rdf:type schema:PublicationVolume
    107 N26fc0583c2f64f15a19622d539fbc060 rdf:first sg:person.0743710055.82
    108 rdf:rest Nbfc82441a1c54171948d41ed9151e0cb
    109 N37a1778339c442e784df25e00fb94ed1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Positron Emission Tomography Computed Tomography
    111 rdf:type schema:DefinedTerm
    112 N39d81f53d64442fca4921adf07c90411 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Humans
    114 rdf:type schema:DefinedTerm
    115 N4c8593dc89fb4fa9b0622e11b2586b91 rdf:first sg:person.0576060453.34
    116 rdf:rest Nc4d43c12c77049c6887ea6395fe4bd3b
    117 N61b00fc804af44fd9c2c5141650d5e57 rdf:first sg:person.01057176500.15
    118 rdf:rest Nd03615d4dbc74621940943d4dee319ca
    119 N6a128ae9308a42b0ba4f0a3e702f1f15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Treatment Failure
    121 rdf:type schema:DefinedTerm
    122 N6a4c2a5d64a24583a5a832e017a1e2e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Male
    124 rdf:type schema:DefinedTerm
    125 N6e05b24a1c3d477390c3be9f9807f5fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Antigens, CD19
    127 rdf:type schema:DefinedTerm
    128 N7655908b304e4acf8bfffb95e6a14821 schema:name pubmed_id
    129 schema:value 33174144
    130 rdf:type schema:PropertyValue
    131 N7a5d8ed9279e4947a98d819959378bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Fluorodeoxyglucose F18
    133 rdf:type schema:DefinedTerm
    134 N83b1fd07517f4574a428615b6a991845 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Immunotherapy, Adoptive
    136 rdf:type schema:DefinedTerm
    137 N84f71029bb504a958b5f70befc0de58d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Receptors, Chimeric Antigen
    139 rdf:type schema:DefinedTerm
    140 N8e08423b670b47b9a73b871ec6ff1319 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Middle Aged
    142 rdf:type schema:DefinedTerm
    143 N943007c5ff6f46568c6374fc30fc9e6f rdf:first sg:person.01225227464.09
    144 rdf:rest Nc48ebf27f7af43b6a252ebeb9a7ae4cd
    145 Na19f50b9a3154ae1810f242e1397d660 rdf:first sg:person.0704554652.25
    146 rdf:rest N4c8593dc89fb4fa9b0622e11b2586b91
    147 Na513c04bf7ff4b889663b74fb83c1040 schema:name doi
    148 schema:value 10.1007/s12149-020-01544-w
    149 rdf:type schema:PropertyValue
    150 Na5df2c11d2454b798e0a320321023f48 schema:issueNumber 1
    151 rdf:type schema:PublicationIssue
    152 Nab177e9d230d4e36ad6546222819c63d rdf:first sg:person.0763175305.45
    153 rdf:rest N61b00fc804af44fd9c2c5141650d5e57
    154 Nb089fe878cd64c0987bf3dbe2d45aa7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Lymphoma, Large B-Cell, Diffuse
    156 rdf:type schema:DefinedTerm
    157 Nba4d5d4d7d0b4378bac463b90c70752f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Immunotherapy
    159 rdf:type schema:DefinedTerm
    160 Nbfc82441a1c54171948d41ed9151e0cb rdf:first sg:person.01322477140.00
    161 rdf:rest Nf55dda5c829143bbb7c3deac7d6e674a
    162 Nc48ebf27f7af43b6a252ebeb9a7ae4cd rdf:first sg:person.01221366364.07
    163 rdf:rest rdf:nil
    164 Nc4d43c12c77049c6887ea6395fe4bd3b rdf:first sg:person.01006720774.73
    165 rdf:rest N26fc0583c2f64f15a19622d539fbc060
    166 Nd03615d4dbc74621940943d4dee319ca rdf:first sg:person.01225020511.95
    167 rdf:rest N943007c5ff6f46568c6374fc30fc9e6f
    168 Ne43116b969f14a539e78bd220b0ab25e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Female
    170 rdf:type schema:DefinedTerm
    171 Nf55dda5c829143bbb7c3deac7d6e674a rdf:first sg:person.01343324136.30
    172 rdf:rest N1387a09057014a7491e86ebbfc968ecc
    173 Nf6f9558a15df4cb0896e361f572f0130 schema:name dimensions_id
    174 schema:value pub.1132507659
    175 rdf:type schema:PropertyValue
    176 Nfc6773e831434fb8adea496b599563d8 schema:name Springer Nature - SN SciGraph project
    177 rdf:type schema:Organization
    178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Medical and Health Sciences
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Clinical Sciences
    183 rdf:type schema:DefinedTerm
    184 sg:journal.1099601 schema:issn 0914-7187
    185 1864-6433
    186 schema:name Annals of Nuclear Medicine
    187 schema:publisher Springer Nature
    188 rdf:type schema:Periodical
    189 sg:person.01006720774.73 schema:affiliation grid-institutes:grid.10423.34
    190 schema:familyName Werner
    191 schema:givenName Rudolf A.
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006720774.73
    193 rdf:type schema:Person
    194 sg:person.01037024564.42 schema:affiliation grid-institutes:None
    195 schema:familyName Beutel
    196 schema:givenName Gernot
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037024564.42
    198 rdf:type schema:Person
    199 sg:person.01057176500.15 schema:affiliation grid-institutes:grid.10423.34
    200 schema:familyName Ross
    201 schema:givenName Tobias L.
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057176500.15
    203 rdf:type schema:Person
    204 sg:person.01221366364.07 schema:affiliation grid-institutes:None
    205 schema:familyName Koenecke
    206 schema:givenName Christian
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221366364.07
    208 rdf:type schema:Person
    209 sg:person.01225020511.95 schema:affiliation grid-institutes:grid.10423.34
    210 schema:familyName Bengel
    211 schema:givenName Frank M.
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225020511.95
    213 rdf:type schema:Person
    214 sg:person.01225227464.09 schema:affiliation grid-institutes:None
    215 schema:familyName Ganser
    216 schema:givenName Arnold
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225227464.09
    218 rdf:type schema:Person
    219 sg:person.01322477140.00 schema:affiliation grid-institutes:None
    220 schema:familyName Skripuletz
    221 schema:givenName Thomas
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322477140.00
    223 rdf:type schema:Person
    224 sg:person.01343324136.30 schema:affiliation grid-institutes:grid.10423.34
    225 schema:familyName David
    226 schema:givenName Sascha
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343324136.30
    228 rdf:type schema:Person
    229 sg:person.0576060453.34 schema:affiliation grid-institutes:None
    230 schema:familyName Schultze-Florey
    231 schema:givenName Christian
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576060453.34
    233 rdf:type schema:Person
    234 sg:person.0704554652.25 schema:affiliation grid-institutes:grid.10423.34
    235 schema:familyName Derlin
    236 schema:givenName Thorsten
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704554652.25
    238 rdf:type schema:Person
    239 sg:person.0743710055.82 schema:affiliation grid-institutes:None
    240 schema:familyName Möhn
    241 schema:givenName Nora
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743710055.82
    243 rdf:type schema:Person
    244 sg:person.0763175305.45 schema:affiliation grid-institutes:None
    245 schema:familyName Eder
    246 schema:givenName Matthias
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763175305.45
    248 rdf:type schema:Person
    249 sg:pub.10.1007/s00259-014-2983-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046004455
    250 https://doi.org/10.1007/s00259-014-2983-4
    251 rdf:type schema:CreativeWork
    252 grid-institutes:None schema:alternateName Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany
    253 Department of Neurology, Hannover, Germany
    254 schema:name Department of Hematology, Hemostasis, Oncology and Stem-Cell Transplantation, Hannover, Germany
    255 Department of Neurology, Hannover, Germany
    256 rdf:type schema:Organization
    257 grid-institutes:grid.10423.34 schema:alternateName Department of Nephrology, Hannover Medical School, Hannover, Germany
    258 Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany
    259 schema:name Department of Nephrology, Hannover Medical School, Hannover, Germany
    260 Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany
    261 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...