Technical feasibility, radiation dosimetry and clinical use of 18F-sodium fluoride (NaF) in evaluation of metastatic bone disease in pediatric population View Full Text


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Article Info

DATE

2018-11

AUTHORS

Sharjeel Usmani, Tim Van den Wyngaert, Najeeb Ahmed, Fahad Marafi, Abdulredha Esmail, Fareeda al kandari, Mishari al Nuaimi, Gopinath Gnanasegaran

ABSTRACT

PURPOSE: The role of 18F-fluoride (18F-NaF) PET-CT for the detection of bone metastases in adults is well established and is considered superior to conventional bone scintigraphy. However, data pertaining use of 18F-NaF PET-CT in pediatric oncology is relatively sparse. The aim of the present study is to retrospectively analyze and share a single-center experience of 18F-NaF PET-CT in pediatric population and to provide preliminary information regarding imaging technique, feasibility of this modality in young patients and radiation dosimetry measurements in pediatric oncology cases. MATERIALS AND METHODS: Twenty-four pediatric patients (mean age 8.0 ± 3.9) were included in the study for retrospective analysis. All patients were referred for primary staging or restaging for potential osseous metastatic disease and PET-CT scan was performed by injecting 2.2 MBq/kg (0.06 mCi/kg) of 18F-NaF. RESULTS: Nine patients were imaged for primary staging and in all cases increase osteoblastic activity was seen in the primary tumor and of these, metastatic bone disease was identified in 2/9 patients. In the restaging group comprising 15/24 patients, metastatic deposits were identified in 3/15 whilst no disease was seen in the remaining 12 patients. Patients were injected a mean dose of 90.35 ± 22.9 MBq with an estimated mean effective absorbed doses of 2.98 ± 0.75 mSv for 18F-NaF and 3.37 ± 2.4 mSv for CT alone. Mean cumulative effective dose of 18F-NaF PET-CT scan was 5.11 ± 2.7 mSv. CONCLUSIONS: 18F-NaF PET-CT may be a feasible alternative to 99mTc MDP for radionuclide bone scintigraphy in the evaluation of pediatric bone pathology. Due to its better pharmacokinetics, there is potential that osseous staging can be achieved with relatively low doses and with a similar radiation burden as with 99mTc-MDP imaging. More... »

PAGES

594-601

References to SciGraph publications

  • 2015-10. 18F-NaF PET/CT: EANM procedure guidelines for bone imaging in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2011-05. Pediatric oncology and the future of oncological imaging in PEDIATRIC RADIOLOGY
  • 2016-05. Diffusion-weighted imaging in pediatric body magnetic resonance imaging in PEDIATRIC RADIOLOGY
  • 2009-10. Imaging metastatic bone disease from carcinoma of the prostate in BRITISH JOURNAL OF CANCER
  • 2008-07. Fluorine-18 NaF PET imaging of child abuse in PEDIATRIC RADIOLOGY
  • 2009-03. The new EANM paediatric dosage card in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12149-018-1279-3

    DOI

    http://dx.doi.org/10.1007/s12149-018-1279-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105641006

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30019285


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