Coronary flow reserve and relative flow reserve measured by N-13 ammonia PET for characterization of coronary artery disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11-15

AUTHORS

Sang-Geon Cho, Ki Seong Park, Jahae Kim, Sae-Ryung Kang, Ho-Chun Song, Ju Han Kim, Jae Yeong Cho, Young Joon Hong, Zeenat Jabin, Hee Jeong Park, Geum-Cheol Jeong, Seong Young Kwon, Jin Chul Paeng, Hyeon Sik Kim, Jung-Joon Min, Ernest V. Garcia, Henry Hee-Seung Bom

ABSTRACT

ObjectiveWe evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD).MethodsSixty-nine consecutive stable angina patients underwent N-13 ammonia PET, coronary computed tomography angiography (CCTA), and if necessary, invasive coronary angiography (CAG) within 2 weeks. Myocardial blood flow (MBF), CFR, RFR, and coronary vascular resistance of the reference arterial territory (CVRref) were measured by N-13 ammonia PET. The presence of significant stenosis (SS) and diffuse atherosclerosis (DA) was evaluated on CCTA and CAG. Functional parameters measured by PET were compared among arteries with and without SS and DA.ResultsArteries with SS and those with DA showed significantly lower stress MBF, as compared to those without. RFR was significantly lower in arteries with SS as compared to those without, while CFR was not. CFR was significantly lower in arteries with DA as compared to those without, while RFR was not. Among arteries without SS, CFR was significantly lower in those with DA as compared to those without. However, among arteries with SS, CFR was similar between those with and without DA. In contrast, RFR was significantly lower in arteries with SS, regardless of the presence of DA. CFR and RFR showed a weak positive correlation (r = 0.269) with discordance in 24 cases (35%). Among the arteries with CFR-RFR discordance, the prevalence of DA was significantly higher in those with low CFR but preserved RFR, as compared to those with preserved CFR but low RFR (75 vs 25%, p = 0.028). CVRref was significantly higher in arteries with DA, implicating a correlation of DA with underlying microvascular disease.ConclusionsCFR and RFR measured by myocardial perfusion PET could provide a comprehensive information for characterization of epicardial CAD. More... »

PAGES

144-152

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12149-016-1138-z

DOI

http://dx.doi.org/10.1007/s12149-016-1138-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016590376

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27848160


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22 schema:description ObjectiveWe evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD).MethodsSixty-nine consecutive stable angina patients underwent N-13 ammonia PET, coronary computed tomography angiography (CCTA), and if necessary, invasive coronary angiography (CAG) within 2 weeks. Myocardial blood flow (MBF), CFR, RFR, and coronary vascular resistance of the reference arterial territory (CVRref) were measured by N-13 ammonia PET. The presence of significant stenosis (SS) and diffuse atherosclerosis (DA) was evaluated on CCTA and CAG. Functional parameters measured by PET were compared among arteries with and without SS and DA.ResultsArteries with SS and those with DA showed significantly lower stress MBF, as compared to those without. RFR was significantly lower in arteries with SS as compared to those without, while CFR was not. CFR was significantly lower in arteries with DA as compared to those without, while RFR was not. Among arteries without SS, CFR was significantly lower in those with DA as compared to those without. However, among arteries with SS, CFR was similar between those with and without DA. In contrast, RFR was significantly lower in arteries with SS, regardless of the presence of DA. CFR and RFR showed a weak positive correlation (r = 0.269) with discordance in 24 cases (35%). Among the arteries with CFR-RFR discordance, the prevalence of DA was significantly higher in those with low CFR but preserved RFR, as compared to those with preserved CFR but low RFR (75 vs 25%, p = 0.028). CVRref was significantly higher in arteries with DA, implicating a correlation of DA with underlying microvascular disease.ConclusionsCFR and RFR measured by myocardial perfusion PET could provide a comprehensive information for characterization of epicardial CAD.
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29 ObjectiveWe
30 ResultsArteries
31 ammonia positron emission tomography
32 angina patients
33 angiography
34 arterial territories
35 artery
36 artery disease
37 atherosclerosis
38 blood flow
39 cases
40 characterization
41 comprehensive information
42 consecutive stable angina patients
43 contrast
44 coronary angiography
45 coronary artery disease
46 coronary flow reserve
47 coronary vascular resistance
48 correlation
49 diffuse atherosclerosis
50 discordance
51 disease
52 emission tomography
53 epicardial coronary artery disease
54 flow
55 flow reserve
56 functional parameters
57 information
58 invasive coronary angiography
59 lower coronary flow reserve
60 lower stress MBF
61 microvascular disease
62 myocardial blood flow
63 myocardial perfusion positron emission tomography
64 parameters
65 patients
66 perfusion positron emission tomography
67 positive correlation
68 positron emission tomography
69 presence
70 prevalence
71 relationship
72 relative flow reserve
73 reserves
74 resistance
75 significant stenosis
76 stable angina patients
77 stenosis
78 stress myocardial blood flow
79 territory
80 tomography
81 tomography angiography
82 vascular resistance
83 weak positive correlation
84 weeks
85 schema:name Coronary flow reserve and relative flow reserve measured by N-13 ammonia PET for characterization of coronary artery disease
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