Metformin discontinuation less than 72 h is suboptimal for F-18 FDG PET/CT interpretation of the bowel View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

Suk Hyun Lee, Soyoung Jin, Hyo Sang Lee, Jin-Sook Ryu, Jong Jin Lee

ABSTRACT

OBJECTIVE: Metformin-induced [F-18] fluorodeoxyglucose (FDG) bowel uptake can hinder positron emission tomography/computed tomography (PET/CT) evaluation of the bowel. This study aimed to investigate the segmental bowel uptake of FDG according to metformin discontinuation times up to 72 h. METHODS: We retrospectively divided 240 diabetic patients into four groups: metformin discontinuation <24 h (group A; n = 86), 24-48 h (group B; n = 40), 48-72 h (group C; n = 12), and no metformin (control group; n = 102). Segmental FDG bowel uptakes were measured visually (four-point scale) and semi-quantitatively (maximum standardized uptake value). RESULTS: Compared with the control group, FDG uptake increased significantly from the ileum to the rectosigmoid colon in group A, from the transverse to the rectosigmoid colon in group B, and from the descending colon to the rectosigmoid colon in group C in both visual and semi-quantitative analyses. CONCLUSIONS: Metformin discontinuation for <72 h is likely suboptimal for PET/CT image interpretation, especially with respect to the distal segments of the colon. More... »

PAGES

629-636

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12149-016-1106-7

DOI

http://dx.doi.org/10.1007/s12149-016-1106-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048309476

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27392947


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