Phase IIa clinical study of [18F]fluciclovine: efficacy and safety of a new PET tracer for brain tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

Akihide Kondo, Hisato Ishii, Shigeki Aoki, Masaru Suzuki, Hidekazu Nagasawa, Kazuo Kubota, Ryogo Minamimoto, Atsushi Arakawa, Masato Tominaga, Hajime Arai

ABSTRACT

OBJECTIVE: [18F]Fluciclovine (anti-[18F]FACBC) has demonstrated diagnostic efficacy for cancers of the brain where [18F]fludeoxyglucose has limitations. We conducted a phase IIa study of anti-[18F]FACBC to assess its accumulation pattern and safety in patients with malignant glioma. METHODS: Five patients with glioma scheduled for brain tumor resection received anti-[18F]FACBC. Brain positron emission tomography (PET) was performed following intravenous administration of anti-[18F]FACBC, and subsequently, preoperative gadolinium contrast-enhanced T1-weighted (CE-T1W) magnetic resonance imaging (MRI) was performed for surgery. Specimens for histopathological evaluation were collected during surgery, and their location was precisely determined on CE-T1W MRI and anti-[18F]FACBC PET/CT images. In addition, tumor extent defined on the MRI and PET/CT images was compared. To determine time-activity curves for anti-[18F]FACBC uptake in brain tumor and normal tissues, regions of interest were set in the brain tumor, contralateral normal tissue and the cerebellum, and their standardized uptake values (SUV) were calculated. The safety of anti-[18F]FACBC was assessed based on subjective symptoms and objective findings, electrocardiograms, vital signs, laboratory results, and the incidence of adverse events. RESULTS: Anti-[18F]FACBC accumulated in the malignant gliomas of all patients. CE-T1W MRI detected gliomas in all patients, but anti-[18F]FACBC PET/CT generally delineated wider regions of tumor extent than CE-T1W MRI. Two of the histopathologically confirmed tumors were located in regions that were defined using anti-[18F]FACBC PET/CT, but not using CE-T1W MRI. Two patients experienced three mild adverse events: one complained of a dull headache and later a mild headache, and the other showed general malaise. These symptoms resolved spontaneously without treatment. Only the mild headache could not be ruled out from having a causal relationship with anti-[18F]FACBC. Favorable T/N ratios regarding anti-[18F]FACBC uptake between tumors and normal control tissues were demonstrated in this trial. CONCLUSIONS: It is suggested that anti-[18F]FACBC PET/CT has the ability to delineate glioma spread that is undetectable using CE-T1W MRI. Anti-[18F]FACBC is safe in patients with malignant glioma. This study was registered in the Japan Pharmaceutical Information Center Clinical Trials Information, which is one of the World Health Organization registries (registration number: JapicCTI-111387). More... »

PAGES

608-618

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12149-016-1102-y

DOI

http://dx.doi.org/10.1007/s12149-016-1102-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042318134

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27418267


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carboxylic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclobutanes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radioactive Tracers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Safety", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Neurosurgery, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondo", 
        "givenName": "Akihide", 
        "id": "sg:person.01024474307.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024474307.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Neurosurgery, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishii", 
        "givenName": "Hisato", 
        "id": "sg:person.01011746701.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011746701.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Radiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "Shigeki", 
        "id": "sg:person.01215036461.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215036461.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Radiology, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20, Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Masaru", 
        "id": "sg:person.01237674230.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237674230.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Radiology, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20, Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagasawa", 
        "givenName": "Hidekazu", 
        "id": "sg:person.01343251757.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343251757.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Global Health and Medicine", 
          "id": "https://www.grid.ac/institutes/grid.45203.30", 
          "name": [
            "Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, 162-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kubota", 
        "givenName": "Kazuo", 
        "id": "sg:person.0716110777.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716110777.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center For Global Health and Medicine", 
          "id": "https://www.grid.ac/institutes/grid.45203.30", 
          "name": [
            "Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, 162-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minamimoto", 
        "givenName": "Ryogo", 
        "id": "sg:person.0714511602.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714511602.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Human Pathology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arakawa", 
        "givenName": "Atsushi", 
        "id": "sg:person.0625123312.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625123312.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinical Development Department, Nihon Medi-Physics Co., Ltd., 3-4-10, Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tominaga", 
        "givenName": "Masato", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Neurosurgery, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arai", 
        "givenName": "Hajime", 
        "id": "sg:person.01325532346.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325532346.63"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2015.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003400343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004384599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2009.01.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005132334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2015.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005626670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/nos218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006436675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awh399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008117412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-012-2291-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009976789", 
          "https://doi.org/10.1007/s00259-012-2291-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2004.048520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013287933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2013.08.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014794865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2015.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017110501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2013.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018019726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1331.2010.03151.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022073510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2010.02.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022476528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2003.028480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024043727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.13130240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025619996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3174/ajnr.a3372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026179052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-3745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026240673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12149-011-0477-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033908715", 
          "https://doi.org/10.1007/s12149-011-0477-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncel.2014.00418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036906661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3174/ajnr.a3324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038348033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-8043(03)00029-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039671851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-8043(03)00029-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039671851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.113100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043433723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11307-013-0693-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050510898", 
          "https://doi.org/10.1007/s11307-013-0693-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(06)70665-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052107910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052112015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00598951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052252182", 
          "https://doi.org/10.1007/bf00598951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00598951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052252182", 
          "https://doi.org/10.1007/bf00598951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/nov118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059934965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/42.563664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061170515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2000.93.6.1003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2000.93.6.1003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2000.93.6.1003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2005.103.3.0498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4414/smw.2015.14082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072528458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074252654", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077249085", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078566742", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079300204", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-11", 
    "datePublishedReg": "2016-11-01", 
    "description": "OBJECTIVE: [18F]Fluciclovine (anti-[18F]FACBC) has demonstrated diagnostic efficacy for cancers of the brain where [18F]fludeoxyglucose has limitations. We conducted a phase IIa study of anti-[18F]FACBC to assess its accumulation pattern and safety in patients with malignant glioma.\nMETHODS: Five patients with glioma scheduled for brain tumor resection received anti-[18F]FACBC. Brain positron emission tomography (PET) was performed following intravenous administration of anti-[18F]FACBC, and subsequently, preoperative gadolinium contrast-enhanced T1-weighted (CE-T1W) magnetic resonance imaging (MRI) was performed for surgery. Specimens for histopathological evaluation were collected during surgery, and their location was precisely determined on CE-T1W MRI and anti-[18F]FACBC PET/CT images. In addition, tumor extent defined on the MRI and PET/CT images was compared. To determine time-activity curves for anti-[18F]FACBC uptake in brain tumor and normal tissues, regions of interest were set in the brain tumor, contralateral normal tissue and the cerebellum, and their standardized uptake values (SUV) were calculated. The safety of anti-[18F]FACBC was assessed based on subjective symptoms and objective findings, electrocardiograms, vital signs, laboratory results, and the incidence of adverse events.\nRESULTS: Anti-[18F]FACBC accumulated in the malignant gliomas of all patients. CE-T1W MRI detected gliomas in all patients, but anti-[18F]FACBC PET/CT generally delineated wider regions of tumor extent than CE-T1W MRI. Two of the histopathologically confirmed tumors were located in regions that were defined using anti-[18F]FACBC PET/CT, but not using CE-T1W MRI. Two patients experienced three mild adverse events: one complained of a dull headache and later a mild headache, and the other showed general malaise. These symptoms resolved spontaneously without treatment. Only the mild headache could not be ruled out from having a causal relationship with anti-[18F]FACBC. Favorable T/N ratios regarding anti-[18F]FACBC uptake between tumors and normal control tissues were demonstrated in this trial.\nCONCLUSIONS: It is suggested that anti-[18F]FACBC PET/CT has the ability to delineate glioma spread that is undetectable using CE-T1W MRI. Anti-[18F]FACBC is safe in patients with malignant glioma. This study was registered in the Japan Pharmaceutical Information Center Clinical Trials Information, which is one of the World Health Organization registries (registration number: JapicCTI-111387).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12149-016-1102-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1099601", 
        "issn": [
          "0914-7187", 
          "1864-6433"
        ], 
        "name": "Annals of Nuclear Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "name": "Phase IIa clinical study of [18F]fluciclovine: efficacy and safety of a new PET tracer for brain tumors", 
    "pagination": "608-618", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c99492288dbdee272b795aa487ac445813659b3add3a5096722a8a4f663eedfe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27418267"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8913398"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12149-016-1102-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042318134"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12149-016-1102-y", 
      "https://app.dimensions.ai/details/publication/pub.1042318134"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70058_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12149-016-1102-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12149-016-1102-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12149-016-1102-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12149-016-1102-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12149-016-1102-y'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      79 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12149-016-1102-y schema:about N045115473e184401bffabb675a99cd7b
2 N0a53c0dcef4e42dea7dc4fe912db0948
3 N0b565fa38ba648fca1d035d1179718c8
4 N215284db4e77447bbddc901998480555
5 N3d9277bb56a8424eb7b2c3bfce77fd28
6 N4997d1fbc3e6400590a86cdea848f8e5
7 N7b09ffa2d76244a19f1680d625275c6d
8 N8ac4b1c8439248e7af06751ed23c6bbf
9 N9da35dc8277b46298348421415e86aa4
10 Na52625c018214b85a083163b3de6763a
11 Nbb204fa655c9497885f0288b9246bd0e
12 Nd9166e2cdf9041e2ae4deb28529f9f64
13 Ndab8df9173d74be3b0cefcd795a8a78b
14 Neeb6a18e52294562a71ae1b893d08003
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N1a6e1b82fe0846219bdd0a41eb789f15
18 schema:citation sg:pub.10.1007/bf00598951
19 sg:pub.10.1007/s00259-012-2291-9
20 sg:pub.10.1007/s11307-013-0693-0
21 sg:pub.10.1007/s12149-011-0477-z
22 https://app.dimensions.ai/details/publication/pub.1074252654
23 https://app.dimensions.ai/details/publication/pub.1077249085
24 https://app.dimensions.ai/details/publication/pub.1078566742
25 https://app.dimensions.ai/details/publication/pub.1079300204
26 https://doi.org/10.1016/j.bmc.2009.01.032
27 https://doi.org/10.1016/j.bmcl.2010.02.048
28 https://doi.org/10.1016/j.brainres.2013.08.037
29 https://doi.org/10.1016/j.nucmedbio.2013.04.007
30 https://doi.org/10.1016/j.nucmedbio.2015.01.008
31 https://doi.org/10.1016/j.nucmedbio.2015.04.008
32 https://doi.org/10.1016/j.nucmedbio.2015.06.001
33 https://doi.org/10.1016/s0969-8043(03)00029-0
34 https://doi.org/10.1016/s1470-2045(06)70665-9
35 https://doi.org/10.1056/nejmoa043330
36 https://doi.org/10.1093/annonc/mdu050
37 https://doi.org/10.1093/brain/awh399
38 https://doi.org/10.1093/neuonc/nos218
39 https://doi.org/10.1093/neuonc/nov118
40 https://doi.org/10.1109/42.563664
41 https://doi.org/10.1111/j.1468-1331.2010.03151.x
42 https://doi.org/10.1136/jnnp.2003.028480
43 https://doi.org/10.1136/jnnp.2004.048520
44 https://doi.org/10.1148/radiol.13130240
45 https://doi.org/10.1158/0008-5472.can-14-3745
46 https://doi.org/10.2967/jnumed.112.113100
47 https://doi.org/10.3171/2015.5.jns142087
48 https://doi.org/10.3171/jns.2000.93.6.1003
49 https://doi.org/10.3171/jns.2005.103.3.0498
50 https://doi.org/10.3174/ajnr.a3324
51 https://doi.org/10.3174/ajnr.a3372
52 https://doi.org/10.3389/fncel.2014.00418
53 https://doi.org/10.4414/smw.2015.14082
54 schema:datePublished 2016-11
55 schema:datePublishedReg 2016-11-01
56 schema:description OBJECTIVE: [18F]Fluciclovine (anti-[18F]FACBC) has demonstrated diagnostic efficacy for cancers of the brain where [18F]fludeoxyglucose has limitations. We conducted a phase IIa study of anti-[18F]FACBC to assess its accumulation pattern and safety in patients with malignant glioma. METHODS: Five patients with glioma scheduled for brain tumor resection received anti-[18F]FACBC. Brain positron emission tomography (PET) was performed following intravenous administration of anti-[18F]FACBC, and subsequently, preoperative gadolinium contrast-enhanced T1-weighted (CE-T1W) magnetic resonance imaging (MRI) was performed for surgery. Specimens for histopathological evaluation were collected during surgery, and their location was precisely determined on CE-T1W MRI and anti-[18F]FACBC PET/CT images. In addition, tumor extent defined on the MRI and PET/CT images was compared. To determine time-activity curves for anti-[18F]FACBC uptake in brain tumor and normal tissues, regions of interest were set in the brain tumor, contralateral normal tissue and the cerebellum, and their standardized uptake values (SUV) were calculated. The safety of anti-[18F]FACBC was assessed based on subjective symptoms and objective findings, electrocardiograms, vital signs, laboratory results, and the incidence of adverse events. RESULTS: Anti-[18F]FACBC accumulated in the malignant gliomas of all patients. CE-T1W MRI detected gliomas in all patients, but anti-[18F]FACBC PET/CT generally delineated wider regions of tumor extent than CE-T1W MRI. Two of the histopathologically confirmed tumors were located in regions that were defined using anti-[18F]FACBC PET/CT, but not using CE-T1W MRI. Two patients experienced three mild adverse events: one complained of a dull headache and later a mild headache, and the other showed general malaise. These symptoms resolved spontaneously without treatment. Only the mild headache could not be ruled out from having a causal relationship with anti-[18F]FACBC. Favorable T/N ratios regarding anti-[18F]FACBC uptake between tumors and normal control tissues were demonstrated in this trial. CONCLUSIONS: It is suggested that anti-[18F]FACBC PET/CT has the ability to delineate glioma spread that is undetectable using CE-T1W MRI. Anti-[18F]FACBC is safe in patients with malignant glioma. This study was registered in the Japan Pharmaceutical Information Center Clinical Trials Information, which is one of the World Health Organization registries (registration number: JapicCTI-111387).
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N2c67a1921a3645b08afd634b044cb408
61 Nfc1074c6e10049f9b887a16aa7bfff7a
62 sg:journal.1099601
63 schema:name Phase IIa clinical study of [18F]fluciclovine: efficacy and safety of a new PET tracer for brain tumors
64 schema:pagination 608-618
65 schema:productId N0f38f997cb6b4cfdad903739aa332636
66 N59af0ee550d9408eb96a2aa6e8628f86
67 N80175c9d06074df680db45f6b7597a49
68 Nd1ac4ec9d5fe435eae1ba031ad418833
69 Ne58a7d92bda640aa80870adeaef15321
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042318134
71 https://doi.org/10.1007/s12149-016-1102-y
72 schema:sdDatePublished 2019-04-11T12:42
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nd46c55715a8b4a5db712c3a5acf2b448
75 schema:url https://link.springer.com/10.1007%2Fs12149-016-1102-y
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N03998bd6b53d4301a26de4a03a6b3978 rdf:first sg:person.0714511602.66
80 rdf:rest N34bee9dcf39e43959d718ab7013fd42c
81 N045115473e184401bffabb675a99cd7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Aged
83 rdf:type schema:DefinedTerm
84 N0a53c0dcef4e42dea7dc4fe912db0948 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Middle Aged
86 rdf:type schema:DefinedTerm
87 N0b565fa38ba648fca1d035d1179718c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Cyclobutanes
89 rdf:type schema:DefinedTerm
90 N0f38f997cb6b4cfdad903739aa332636 schema:name dimensions_id
91 schema:value pub.1042318134
92 rdf:type schema:PropertyValue
93 N1a6e1b82fe0846219bdd0a41eb789f15 rdf:first sg:person.01024474307.42
94 rdf:rest N75ecc89962db4c658efd7b05e723e3cf
95 N1c16599565f84a1c92107441c882cde0 schema:affiliation N2487dd9d4c414da0a02ba8335848cdc5
96 schema:familyName Tominaga
97 schema:givenName Masato
98 rdf:type schema:Person
99 N215284db4e77447bbddc901998480555 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Radioactive Tracers
101 rdf:type schema:DefinedTerm
102 N2487dd9d4c414da0a02ba8335848cdc5 schema:name Clinical Development Department, Nihon Medi-Physics Co., Ltd., 3-4-10, Shinsuna, Koto-ku, 136-0075, Tokyo, Japan
103 rdf:type schema:Organization
104 N2c67a1921a3645b08afd634b044cb408 schema:issueNumber 9
105 rdf:type schema:PublicationIssue
106 N34bee9dcf39e43959d718ab7013fd42c rdf:first sg:person.0625123312.22
107 rdf:rest Nccaada95e5fb4f2e820e1f439c80d98a
108 N3d9277bb56a8424eb7b2c3bfce77fd28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Female
110 rdf:type schema:DefinedTerm
111 N4078c8b04cc2491196c6a83ed986feb9 rdf:first sg:person.01215036461.13
112 rdf:rest N89d5c9eeaa324482aaa11600787f9a9c
113 N458145b6ff7344fca36e43c93f9851c5 rdf:first sg:person.01343251757.23
114 rdf:rest N4b959001d414497b86307bb4af7b55a1
115 N4997d1fbc3e6400590a86cdea848f8e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Safety
117 rdf:type schema:DefinedTerm
118 N4b959001d414497b86307bb4af7b55a1 rdf:first sg:person.0716110777.77
119 rdf:rest N03998bd6b53d4301a26de4a03a6b3978
120 N59af0ee550d9408eb96a2aa6e8628f86 schema:name nlm_unique_id
121 schema:value 8913398
122 rdf:type schema:PropertyValue
123 N75ecc89962db4c658efd7b05e723e3cf rdf:first sg:person.01011746701.03
124 rdf:rest N4078c8b04cc2491196c6a83ed986feb9
125 N7b09ffa2d76244a19f1680d625275c6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Biological Transport
127 rdf:type schema:DefinedTerm
128 N80175c9d06074df680db45f6b7597a49 schema:name readcube_id
129 schema:value c99492288dbdee272b795aa487ac445813659b3add3a5096722a8a4f663eedfe
130 rdf:type schema:PropertyValue
131 N84088cbb247445fd8a0e88cbc8de41df rdf:first sg:person.01325532346.63
132 rdf:rest rdf:nil
133 N89d5c9eeaa324482aaa11600787f9a9c rdf:first sg:person.01237674230.29
134 rdf:rest N458145b6ff7344fca36e43c93f9851c5
135 N8ac4b1c8439248e7af06751ed23c6bbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Carboxylic Acids
137 rdf:type schema:DefinedTerm
138 N9da35dc8277b46298348421415e86aa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Male
140 rdf:type schema:DefinedTerm
141 Na52625c018214b85a083163b3de6763a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Brain Neoplasms
143 rdf:type schema:DefinedTerm
144 Nbb204fa655c9497885f0288b9246bd0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 Nccaada95e5fb4f2e820e1f439c80d98a rdf:first N1c16599565f84a1c92107441c882cde0
148 rdf:rest N84088cbb247445fd8a0e88cbc8de41df
149 Nd1ac4ec9d5fe435eae1ba031ad418833 schema:name pubmed_id
150 schema:value 27418267
151 rdf:type schema:PropertyValue
152 Nd46c55715a8b4a5db712c3a5acf2b448 schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 Nd9166e2cdf9041e2ae4deb28529f9f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Positron-Emission Tomography
156 rdf:type schema:DefinedTerm
157 Ndab8df9173d74be3b0cefcd795a8a78b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Adult
159 rdf:type schema:DefinedTerm
160 Ne58a7d92bda640aa80870adeaef15321 schema:name doi
161 schema:value 10.1007/s12149-016-1102-y
162 rdf:type schema:PropertyValue
163 Neeb6a18e52294562a71ae1b893d08003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Glioma
165 rdf:type schema:DefinedTerm
166 Nfc1074c6e10049f9b887a16aa7bfff7a schema:volumeNumber 30
167 rdf:type schema:PublicationVolume
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
172 schema:name Clinical Sciences
173 rdf:type schema:DefinedTerm
174 sg:journal.1099601 schema:issn 0914-7187
175 1864-6433
176 schema:name Annals of Nuclear Medicine
177 rdf:type schema:Periodical
178 sg:person.01011746701.03 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
179 schema:familyName Ishii
180 schema:givenName Hisato
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011746701.03
182 rdf:type schema:Person
183 sg:person.01024474307.42 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
184 schema:familyName Kondo
185 schema:givenName Akihide
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024474307.42
187 rdf:type schema:Person
188 sg:person.01215036461.13 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
189 schema:familyName Aoki
190 schema:givenName Shigeki
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215036461.13
192 rdf:type schema:Person
193 sg:person.01237674230.29 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
194 schema:familyName Suzuki
195 schema:givenName Masaru
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237674230.29
197 rdf:type schema:Person
198 sg:person.01325532346.63 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
199 schema:familyName Arai
200 schema:givenName Hajime
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325532346.63
202 rdf:type schema:Person
203 sg:person.01343251757.23 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
204 schema:familyName Nagasawa
205 schema:givenName Hidekazu
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343251757.23
207 rdf:type schema:Person
208 sg:person.0625123312.22 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
209 schema:familyName Arakawa
210 schema:givenName Atsushi
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625123312.22
212 rdf:type schema:Person
213 sg:person.0714511602.66 schema:affiliation https://www.grid.ac/institutes/grid.45203.30
214 schema:familyName Minamimoto
215 schema:givenName Ryogo
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714511602.66
217 rdf:type schema:Person
218 sg:person.0716110777.77 schema:affiliation https://www.grid.ac/institutes/grid.45203.30
219 schema:familyName Kubota
220 schema:givenName Kazuo
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716110777.77
222 rdf:type schema:Person
223 sg:pub.10.1007/bf00598951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052252182
224 https://doi.org/10.1007/bf00598951
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/s00259-012-2291-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009976789
227 https://doi.org/10.1007/s00259-012-2291-9
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/s11307-013-0693-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050510898
230 https://doi.org/10.1007/s11307-013-0693-0
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/s12149-011-0477-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033908715
233 https://doi.org/10.1007/s12149-011-0477-z
234 rdf:type schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1074252654 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1077249085 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1078566742 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1079300204 schema:CreativeWork
239 https://doi.org/10.1016/j.bmc.2009.01.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005132334
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.bmcl.2010.02.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022476528
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.brainres.2013.08.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014794865
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.nucmedbio.2013.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018019726
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.nucmedbio.2015.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017110501
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.nucmedbio.2015.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005626670
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.nucmedbio.2015.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003400343
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0969-8043(03)00029-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039671851
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s1470-2045(06)70665-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052107910
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1056/nejmoa043330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052112015
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/annonc/mdu050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004384599
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/brain/awh399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008117412
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/neuonc/nos218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006436675
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/neuonc/nov118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059934965
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1109/42.563664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061170515
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1111/j.1468-1331.2010.03151.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022073510
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1136/jnnp.2003.028480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024043727
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1136/jnnp.2004.048520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013287933
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1148/radiol.13130240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025619996
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1158/0008-5472.can-14-3745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026240673
278 rdf:type schema:CreativeWork
279 https://doi.org/10.2967/jnumed.112.113100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043433723
280 rdf:type schema:CreativeWork
281 https://doi.org/10.3171/2015.5.jns142087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071081608
282 rdf:type schema:CreativeWork
283 https://doi.org/10.3171/jns.2000.93.6.1003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071099791
284 rdf:type schema:CreativeWork
285 https://doi.org/10.3171/jns.2005.103.3.0498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071101725
286 rdf:type schema:CreativeWork
287 https://doi.org/10.3174/ajnr.a3324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038348033
288 rdf:type schema:CreativeWork
289 https://doi.org/10.3174/ajnr.a3372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026179052
290 rdf:type schema:CreativeWork
291 https://doi.org/10.3389/fncel.2014.00418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036906661
292 rdf:type schema:CreativeWork
293 https://doi.org/10.4414/smw.2015.14082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072528458
294 rdf:type schema:CreativeWork
295 https://www.grid.ac/institutes/grid.258269.2 schema:alternateName Juntendo University
296 schema:name Department of Human Pathology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
297 Department of Neurosurgery, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
298 Department of Radiology, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20, Shinsuna, Koto-ku, 136-0075, Tokyo, Japan
299 Department of Radiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.45203.30 schema:alternateName National Center For Global Health and Medicine
302 schema:name Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, 162-8655, Tokyo, Japan
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...