Prognostic value of 18F-fluorodeoxyglucose positron emission tomography in patients with gastric neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02-02

AUTHORS

Sun Min Lim, Hyunki Kim, Beodeul Kang, Hyo Song Kim, Sun Young Rha, Sung Hoon Noh, Woo Jin Hyung, Jae-Ho Cheong, Hyoung-Il Kim, Hyun Cheol Chung, Mijin Yun, Arthur Cho, Minkyu Jung

ABSTRACT

ObjectiveGastric neuroendocrine carcinomas (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) are very rare, aggressive tumors of the stomach. We aimed to examine predictive role of pretreatment 18F-FDG PET/CT-assessed metabolic parameter of primary tumors and metastases in patients with gastric NEC and MANEC.MethodsWe conducted a review of the 27 patients with histopathologically confirmed NECs (n = 10) and MANEC (n = 17) of the stomach at our institution between January 2005 and December 2012. All patients underwent 18F-FDG-PET examination at diagnosis. Metabolic parameters [SUVmax, SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG)] of the primary tumor and metastases on baseline PET/CT were analyzed.ResultsThe median follow-up duration was 39.4 months (95 % CI 20.0–58.1 months) and the median overall survival (OS) was 25.7 months (95 % CI 14.1–37.2 months). All gastric lesions were well visualized (average SUVmax = 12.0, range 3.0–41.8). When subjects were divided into two groups by ROC cut-off value of 210.9 and 612, patients with high TLG in primary lesion and metastases showed poorer prognosis compared to low TLG patients (P = 0.09, P = 0.002, respectively). In the sub-analysis of patients with metastasis (n = 12), patients with high TLG in whole body tumor showed significantly shorter OS compared to those with low TLG (31.7 ± 11.4 vs. 7.2 ± 2.1 months, P = 0.006).Conclusion18F-FDG PET/CT is useful in evaluating prognosis of advanced gastric cancer with neuroendocrine carcinoma components. Baseline MTV of primary gastric cancer with metastatic disease, and MTV, TLG of metastases may be prognostic markers in patients with gastric NEC and MANEC. More... »

PAGES

279-286

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12149-016-1059-x

DOI

http://dx.doi.org/10.1007/s12149-016-1059-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053059584

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26837515


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29 schema:description ObjectiveGastric neuroendocrine carcinomas (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) are very rare, aggressive tumors of the stomach. We aimed to examine predictive role of pretreatment 18F-FDG PET/CT-assessed metabolic parameter of primary tumors and metastases in patients with gastric NEC and MANEC.MethodsWe conducted a review of the 27 patients with histopathologically confirmed NECs (n = 10) and MANEC (n = 17) of the stomach at our institution between January 2005 and December 2012. All patients underwent 18F-FDG-PET examination at diagnosis. Metabolic parameters [SUVmax, SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG)] of the primary tumor and metastases on baseline PET/CT were analyzed.ResultsThe median follow-up duration was 39.4 months (95 % CI 20.0–58.1 months) and the median overall survival (OS) was 25.7 months (95 % CI 14.1–37.2 months). All gastric lesions were well visualized (average SUVmax = 12.0, range 3.0–41.8). When subjects were divided into two groups by ROC cut-off value of 210.9 and 612, patients with high TLG in primary lesion and metastases showed poorer prognosis compared to low TLG patients (P = 0.09, P = 0.002, respectively). In the sub-analysis of patients with metastasis (n = 12), patients with high TLG in whole body tumor showed significantly shorter OS compared to those with low TLG (31.7 ± 11.4 vs. 7.2 ± 2.1 months, P = 0.006).Conclusion18F-FDG PET/CT is useful in evaluating prognosis of advanced gastric cancer with neuroendocrine carcinoma components. Baseline MTV of primary gastric cancer with metastatic disease, and MTV, TLG of metastases may be prognostic markers in patients with gastric NEC and MANEC.
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36 schema:keywords CT
37 Conclusion18F-FDG PET/CT
38 MANEC
39 MTV
40 MethodsWe
41 ObjectiveGastric neuroendocrine carcinomas
42 PET examinations
43 PET/CT
44 ROC
45 TLG
46 TLG of metastases
47 TLG patients
48 adenoneuroendocrine carcinoma
49 advanced gastric cancer
50 aggressive tumors
51 baseline MTV
52 baseline PET/CT
53 body tumors
54 cancer
55 carcinoma
56 carcinoma component
57 components
58 diagnosis
59 disease
60 duration
61 emission tomography
62 examination
63 follow
64 gastric cancer
65 gastric lesions
66 gastric neuroendocrine carcinoma
67 group
68 higher TLG
69 institutions
70 lesions
71 low TLG
72 low TLG patients
73 markers
74 median follow
75 median overall survival
76 metabolic parameters
77 metastasis
78 metastatic disease
79 mixed adenoneuroendocrine carcinoma
80 months
81 neuroendocrine carcinoma
82 neuroendocrine carcinoma component
83 overall survival
84 parameters
85 patients
86 poor prognosis
87 positron emission tomography
88 predictive role
89 pretreatment
90 primary gastric cancer
91 primary lesion
92 primary tumor
93 prognosis
94 prognostic marker
95 prognostic value
96 review
97 role
98 shorter overall survival
99 stomach
100 subjects
101 survival
102 tomography
103 tumors
104 values
105 whole-body tumor
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